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| 1 | A bioinformatics method for predicting long noncoding RNAs associated with vascular disease显示文摘Long noncoding RNAs(lncRNAs)play important roles in human diseases including vascular disease.Given the large number of lncRNAs,however,whether the majority of them are associated with vascular disease remains unknown.For this purpose,here we present a genomic location based bioinformatics method to predict the lncRNAs associated with vascular disease.We applied the presented method to globally screen the human lncRNAs potentially involved in vascular disease.As a result,we predicted 3043 putative vascular disease associated lncRNAs.To test the accuracy of the method,we selected 10 lncRNAs predicted to be implicated in proliferation and migration of vascular smooth muscle cells(VSMCs)for further experimental validation.The results confirmed that eight of the 10 lncRNAs(80%)are validated.This result suggests that the presented method has a reliable prediction performance.Finally,the presented bioinformatics method and the predicted vascular disease associated lncRNAs together may provide helps for not only better understanding of the roles of lncRNAs in vascular disease but also the identification of novel molecules for the diagnosis and therapy of vascular disease. | LI JianWei GAO Cheng WANG YuChen MA Wei TU Jian WANG JunPei CHEN ZhenZhen KONG Wei CUI QingHua | 2014 | Science China(Life Sciences)2014，57，8： | 2 |
| 2 | Thermal Runaway of Lithium-Ion Batteries Employing Flame-Retardant Fluorinated Electrolytes显示文摘Fluorinated electrolytes possess good antioxidant capacity that provides high compatibility to high-voltage cathode and flame retardance;thus,they are considered as a promising solution for advanced lithium-ion batteries carrying both high-energy density and high safety.Moreover,the fluorinated electrolytes are widely used to form stable electrolyte interphase,due to their chemical reactivity with lithiated graphite or lithium.However,the influence of this reactivity on the thermal safety of batteries is seldom discussed.Herein,we demonstrate that the flame-retardant fluorinated electrolytes help to reduce the flammability,while the lithium-ion batteries with flame-retardant fluorinated electrolytes still undergo thermal runaway and disclose their different thermal runaway pathway from that of battery with conventional electrolyte.The reduction in fluorinated components(e.g.,LiPF 6 and fluoroethylene carbonate(FEC))by fully lithiated graphite accounts for a significant heat release during battery thermal runaway.The 13%of total heat is sufficient to trigger the chain reactions during battery thermal runaway.This study deepens the understanding of the thermal runaway mechanism of lithium-ion batteries employing flame-retardant fluorinated electrolytes,providing guidance on the concept of electrolyte design for safer lithium-ion batteries. | Junxian Hou Li Wang Xuning Feng Junpei Terada Languang Lu Shigeaki Yamazaki Anyu Su Yoshiko Kuwajima Yongjiang Chen Tomoya Hidaka Xiangming He Hewu Wang Minggao Ouyang | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 3 | Molecular and biochemical characterization of a novel xylanase from the symbiotic Sphingobacterium sp. TN19显示文摘 | Junpei Zhou Huoqing Huang Kun Meng Pengjun Shi Yaru Wang Huiying Luo Peilong Yang Yingguo Bai Zhigang Zhou Bin Yao | 2009 | Applied Microbiology and Biotechnology2009，，2： | 1 |
| 4 | The relationship between 25-hydroxyvitamin D levels and treatment course of pulmonary tuberculosis显示文摘 | Suguru Sato Yoshinori Tanino Junpei Saito Takefumi Nikaido Yayoi Inokoshi Atsuro Fukuhara Naoko Fukuhara Xintao Wang Takashi Ishida Mitsuru Munakata | 2012 | Respiratory Investigation2012，，： | 1 |
| 5 | Caveolin-1-deficient fibroblasts promote migration,invasion,and stemness via activating the TGF-β/Smad signaling pathway in breast cancer cells显示文摘Cancer-associated fibroblasts(CAFs)represent one of the main components in the tumor stroma and play a key role in breast cancer progression.Transforming growth factor-β(TGF-β)has been established to mediate breast cancer metastasis by regulating the epithelial-mesenchymal transition(EMT)and stemness of cancer cells.Caveolin-1(CAV-1)is a scaffold protein of caveolae that is related to the proliferation and metabolism of cancer cells.It is now well demonstrated that CAV-1 deficiency in the tumor stroma is positively correlated with distant metastasis,but the mechanism remains unclear.Here,we explore whether CAV-1-deficient fibroblasts play an essential role in the EMT and stemness of breast cancer cells(BCCs)through TGF-βsignaling.We establish a specific small interfering RNA(siRNA)to inhibit CAV-1 expression in fibroblasts and coculture them with BCCs to investigate the effect of CAV-1-deficient fibroblasts and the tumor microenvironment on breast cancer progression.This study refreshingly points out that CAV-1 deficiency in fibroblasts enhances TGF-β1 secretion and then activates the TGF-β1/Smad signaling pathway of BCCs,thus promoting the metastasis and stemness of BCCs.Collectively,our findings indicate an unexpected role of CAV-1 deficiency in fibroblasts and the tumor microenvironment as a permissive factor,which is regulated by the TGF-β1 signaling pathway in BCCs. | Qingyun Huang Longyuan Wu Yi Wang Xinyu Kong Xinhua Xiao Qiyuan Huang Miao Li Yujia Zhai Fuxiu Shi Ruichen Zhao Junpei Zhong Lixia Xiong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 6 | Intelligent Industrial Auxiliary System Based on AR Technology显示文摘The traditional industrial assembly method is inefficient,and it is difficult to meet the needs of rapid production in modern society.Although many virtual assembly systems based on augmented reality technology have appeared in recent years,most of these assembly systems are noninteractive,nonintelligent,and inefficient.In response to this problem,we combined AR technology and AI technology to design and implement a strong interactive,high-intelligence virtual assembly guidance system in four levels.Finally,we took a UAV assembly as an example to show our design results.Operators can use this system to quickly master the assembly process.Finally,according to some problems encountered in the process of system implementation,the improvement direction of the virtual assembly system is proposed,and the future development of the AR auxiliary industry is proposed.This article describes the functions and implementation process of the four levels of the AR assembly system in detail,which can help readers quickly understand the connection between AR technology and AI technology and understand the principle of the virtual assembly guidance system. | Tao Wang Xinqi Shen Junpei Ma Zhuorui Chang Linyan Guo | 2022 | 国际计算机前沿大会会议论文集2022，，2： | 0 |
| 7 | Industry-Oriented Cloud Edge Intelligent Assembly Guidance System显示文摘In view of the low efficiency of production and assembly in traditional industries,we use AR technology to replace traditional assembly instructions and design an industry-oriented cloud-edge intelligent assembly guidance system.Since the computing power ofARglasses cannot meet the high complexity requirements of scene understanding,we adopt the joint solution of Cloud-Edge.First,the sensor data collected by the AR glasses are streamed to the edge server using high-speed and low-latency wireless interconnection technology.Then,the product artifacts in the data scene are identified and understood through the instance segmentation network BlendMask based on deep learning.Then,the 3D pose of the object is calculated in real time by combining pose estimation and 3D reconstruction.Furthermore,an accurate 3D guidance animation is generated,and the virtual 3D model in the AR glasses is accurately superimposed on the real object to determine whether the assembly is correct in real time.Experiments show that the system effectively combines artificial intelligence and intelligent manufacturing,integrates various elements in the scene in real time to provide operators with multimodal and multidimensional immersive guidance,and corrects in time when assembly errors occur.It can not only quickly guide the operator to complete the learning of the assembly process but also assist the staff in the assembly in real time.Ultimately,it improves assembly speed and accuracy,which in turn improves enterprise productivity. | Difei Liu Zhuorui Chang Junpei Ma Tao Wang Mei Li | 2022 | 国际计算机前沿大会会议论文集2022，，2： | 0 |
| 8 | Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury显示文摘Fidgetin,a microtubule-severing enzyme,regulates neurite outgrowth,axonal regeneration,and cell migration by trimming off the labile domain of microtubule polymers.Because maintenance of the microtubule labile domain is essential for axon initiation,elongation,and navigation,it is of interest to determine whether augmenting the microtubule labile domain via depletion of fidgetin serves as a therapeutic approach to promote axonal regrowth in spinal cord injury.In this study,we constructed rat models of spinal cord injury and sciatic nerve injury.Compared with spinal cord injury,we found that expression level of tyrosinated microtubules in the labile portion of microtubules continuously increased,whereas fidgetin decreased after peripheral nerve injury.Depletion of fidgetin enhanced axon regeneration after spinal cord injury,whereas expression level of end binding protein 3(EB3)markedly increased.Next,we performed RNA interference to knockdown EB3 or fidgetin.We found that deletion of EB3 did not change fidgetin expression.Conversely,deletion of fidgetin markedly increased expression of tyrosinated microtubules and EB3.Deletion of fidgetin increased the amount of EB3 at the end of neurites and thereby increased the level of tyrosinated microtubules.Finally,we deleted EB3 and overexpressed fidgetin.We found that fidgetin trimmed tyrosinated tubulins by interacting with EB3.When fidgetin was deleted,the labile portion of microtubules was elongated,and as a result the length of axons and number of axon branches were increased.These findings suggest that fidgetin can be used as a novel therapeutic target to promote axonal regeneration after spinal cord injury.Furthermore,they reveal an innovative mechanism by which fidgetin preferentially severs labile microtubules. | Chao Ma Junpei Wang Qifeng Tu Weijuan Bo Zunlu Hu Run Zhuo Ronghua Wu Zhangji Dong Liang Qiang Yan Liu Mei Liu | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 9 | In-situ optical pumping for polarizing 3He neutron spin filters at the China Spallation Neutron Source显示文摘In this paper,we present the performance of a recently developed in-situ spin-exchange optically pumped^(3)He-neutron spin filter system at the China Spallation Neutron Source(CSNS).The system achieved a^(3)He polarization of over 74%at the beamline BL-20.Analysis of neutron transmission experiment results reveals a neutron polarization of>90%and an average transmission of 27%for 2.2Åneutrons,which were maintained for a duration of 120 h of beam time.To the best of our knowledge,this is the first in-situ hyperpolarized^(3)He system incorporated on a neutron beamline in China.This technology is expected to provide stable,wide-angle,and highly polarized neutrons at the CSNS for materials research and fundamental neutron physics. | Junpei Zhang Chuyi Huang Zecong Qin Fan Ye Syed Mohd Amir Ahmed Salman Yuchen Dong Long Tian Zachary Norris Buck Wolfgang Kreuzpaintner Matthew Musgrave Xin Qi Tianhao Wang Xin Tong | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，4： | 0 |
| 10 | Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy显示文摘Stress-induced cardiomyopathy,in contrast to acute myocardial infarction,is a type of acute heart failure characterized by reversible left ventricular dysfunction.Cardiac imaging primarily reveals left ventricle myocardial stunning,81.7%of which is apical type.Emotional or psychological stress usually precedes the onset of stress-induced cardiomyopathy,which is increasingly being recognized as a unique neurogenic myocardial stunning disease.To distinguish between acute myocardial infarction and acute viral or auto-immune myocarditis,this review summarizes specific mechanisms of myocardial stunning in stress-induced cardiomyopathy,such as calcium disorders,metabolic alterations,anatomical and histological variations in different parts of the left ventricle,and microvascular dysfunction. | Quanwei Pei Nadine Mbabazi Lina Zou Junpei Zhang Hongpeng Yin Bin Li Jiaxin Wang Weifa Wang Pengqi Lin Junjie Yang Dechun Yin | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
| 11 | The Role of Sleep Deprivation in Arrhythmias显示文摘Sleep is essential to the normal psychological and physiological activities of the human body.Increasing evidence indicates that sleep deprivation is associated with the occurrence,development,and poor treatment effects of various arrhythmias.Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias.In addition,sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders,and immune system dysfunction.Although studies increasingly suggest that pathological sleep patterns are associated with various atrial and ventricular arrhythmias,further research is needed to identify specific mechanisms and recommend therapeutic interventions.This review summarizes the findings of sleep deprivation in animal experiments and clinical studies,current challenges,and future research directions in the field of arrhythmias. | Wenlong Wang Hongpeng Yin Ge Sun Junpei Zhang Jingmei Sun Nadine Mbabazi Lina Zou Bin Li Pengqi Lin Quanwei Pei Xin Wang Penghe Wang Xuanrui Ji Xiufen Qu Dechun Yin | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
| 12 | The DrugPattern tool for drug set enrichment analysis and its prediction for beneficial effects of oxLDL on type 2 diabetes显示文摘Enrichment analysis methods, e.g., gene set enrichment analysis, represent one class of important bioinformatical resources for mining patterns in biomedical datasets. However, tools for inferring patterns and rules of a list of drugs are limited. In this study, we developed a web-based tool, DrugPattern, for drug set enrichment analysis. We first collected and curated 7019 drug sets, including indications,adverse reactions, targets, pathways, etc. from public databases. For a list of interested drugs, DrugPattern then evaluates the significance of the enrichment of these drugs in each of the 7019 drug sets. To validate DrugPattern, we employed it for the prediction of the effects of oxidized low-density lipoprotein(oxLDL), a factor expected to be deleterious. We predicted that oxLDL has beneficial effects on some diseases, most of which were supported by evidence in the literature. Because DrugPattern predicted the potential beneficial effects of oxLDL in type 2 diabetes(T2D), animal experiments were then performed to further verify this prediction. As a result, the experimental evidences validated the DrugPattern prediction that oxLDL indeed has beneficial effects on T2D in the case of energy restriction. These data confirmed the prediction accuracy of our approach and revealed unexpected protective roles for oxLDL in various diseases. This study provides a tool to infer patterns and rules in biomedical datasets based on drug set enrichment analysis. DrugPattern is available at http://gffzz4f18c0dc9a7946e6hkno5xqf06w966xfw.ffgz.tsg.suse.edu.cn/drugpattern. | Chuanbo Huang Weili Yang Junpei wang Yuan Zhou Bin Geng Georgios Kararigas Jichun Yang Qinghua Cui | 2018 | Journal of Genetics and Genomics2018，45，7： | 0 |
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