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| 1 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 4 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 5 | Estimation and minimization of errors caused by sample size effect in the measurement of the normal absorption coefficient of a locally reactive surface 显示文摘 | Eric B Arcanjo L Julio C | 2012 | Applied Acoustics2012，73，67： | 1 |
| 6 | Health professionals for a new cen- tre-y: transforming education to strengthen health systems in an interde- pendent wodd显示文摘 | Julio F Lincoln C Zu]fiqar A B | 2010 | Laneet2010，9756，376： | 1 |
| 7 | Olive oil based lipid emulsion's neutral efeets on neutrophii funciton and leukocyte endothelialcell interacitons 显示文摘 | Amparo B Julio C | 2006 | JPEN2006，30，： | 1 |
| 8 | Separation of tidal and subtidal currents in ship-mounted acoustic doppler current profiler ober- vations 显示文摘 | Julio C Robert C B Richard L | 1992 | Journal of Geophysical Research1992，97，1： | 1 |
| 9 | Political uncertainty and corporate investment cycles显示文摘 | Julio B Yook Y | 2012 | Journal of Finance2012，67，1： | 1 |
| 10 | A state-of-the-art review on shear-friction 显示文摘 | SANTOS P M D JULIO E N B S | 2012 | Engineering Structures2012，45，： | 1 |
| 11 | Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave显示文摘 | Robertson Ragan B Fernandez Julio M | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，12： | 1 |
| 12 | Syn- thesis and characterisation of La1-xCaxFeO3 perovskite- type oxide catalysts for total oxidation of volatile organic compounds 显示文摘 | Barbero B P Julio Andrade Gamboa Cadus L E | 2006 | Appl Catal B: Envir2006，65，： | 1 |
| 13 | On the linear viscoelasticity of thin-walled laminated composite beams显示文摘 | QIAO P Z EVER J B JULIO J D | 1999 | West Virginia University Morgantown WV 26506-6103 USA1999，1999，： | 1 |
| 14 | Transient hypertension directly impairs endothelium-dependent vasodilation of the human microvasculature 显示文摘 | Oscar A Melissa B Julio A | 2000 | Hypertension2000，36，6： | 1 |
| 15 | Olive oil-based lipid emulsion's neutral effects on neutrophil function and leukocyte-endothelial cell interactions显示文摘 | Amparo B Julio C | 2006 | JPEN J Parenter Enteral Nutr2006，30，4： | 1 |
| 16 | A cytochemical,light and electron microscopic study of the peripheral blood leucocytes of hybrid surubim catfish(Pseudoplatystoma corruscans×Pseudoplatystoma fasciatum)显示文摘 | ROGER B BOBBIE B JULIO C | 2003 | Comp Clin Path2003，，12： | 1 |
| 17 | Separation of tidal and subtidal currents in ship-mounted acoustic doppler current profiler ober- vations 显示文摘 | Julio C Robert C B Richard L | 1992 | Journal of Geophysical Research1992，97，1： | 1 |
| 18 | Influence of added concrete compressive strength on adhesion to an existing concrete substrate显示文摘 | JULIO E N B S BRANCO F A B SILVA V D | 2006 | Building and Environment2006，41，： | 1 |
| 19 | Health professionals for a new century: transforming education to strengthen health systems in an inter- dependent world 显示文摘 | Julio F Lincoln C Zulfiqar A B | 2010 | Lancet2010，，376： | 1 |
| 20 | Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells显示文摘 | Marts B Julio S Rafael L | 2002 | Brain Res2002，957，： | 1 |
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