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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Oxidation of KCNB1 K^+ channels in central nervous system and beyond显示文摘KCNB1, a voltage-gated potassium(K+) channel that conducts a major delayed rectifier current in the brain, pancreas and cardiovascular system is a key player in apoptotic programs associated with oxidative stress. As a result, this protein represents a bona fide drug target for limiting the toxic effects of oxygen radicals. Until recently the consensus view was that reactive oxygen species trigger a pro-apoptotic surge in KCNB1 current via phosphorylation and SNARE-dependent incorpora-tion of KCNB1 channels into the plasma membrane. However, new evidence shows that KCNB1 can be modified by oxidants and that oxidized KCNB1 channels can directly activate pro-apoptotic signaling pathways. Hence, a more articulated picture of the pro-apoptotic role of KCNB1 is emerging in which the protein induces cell's death through distinct molecular mechanisms and activation of multiple pathways. In this review article we discuss the diverse functional, toxic and protective roles that KCNB1 channels play in the major organs where they are expressed. | Federico Sesti Xilong Wu Shuang Liu | 2014 | World Journal of Biological Chemistry2014，5，2： | 3 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 4 | Defects of the insulin receptor substrate (IRS) system in human metabolic disorders显示文摘 | SESTI G FEDIR1CI M HR1BAL M L | 2001 | FASEB J2001，15，： | 1 |
| 5 | Effects of growth hormone and insulin- like growth factor - 1 on cardiac hypertrophy of hypertensive patients显示文摘 | Sesti G Sciaequa A Scozzafava A | 2007 | Hypertensions2007，25，2： | 1 |
| 6 | A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease显示文摘 | SESTI G MANNINO GC DE LORENZO C | 2013 | Atherosclerosis2013，231，1： | 1 |
| 7 | Addition of dexmedetomidine to standard sedation regimens after cardiac surgery: an outcomes analysis 显示文摘 | DASTA JF JACOBI J SESTI ABM | 2006 | Pharmacotherapy2006，，6： | 1 |
| 8 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 9 | A common polymorphism associated with antibiotic-induced cardiac arrhythmia显示文摘 | Sesti F Abbott GW Wei J | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 10 | MiRPl forms IKr potassiumchannels with HERG and is associated with cardiac arrhythmia显示文摘 | Abbott GW’Sesti F Splawski l | 1999 | Cell1999，97，2： | 1 |
| 11 | The phospho- diesterase-5 inhibitor tadalafil reduces myocardial infarct size显示文摘 | SESTI C FLORIO V JOHNSON EG et ol | 2007 | Int J Impot Res2007，19，1： | 1 |
| 12 | 血清碱性磷酸酶对未治疗的高血压患者的内皮依赖性血管舒张的不良影响显示文摘组织非特异性碱性磷酸酶是一般人群和肾或心血管病患者总死亡率及心血管死亡率的强有力预测因子。该研究纳入未经治疗的高血压患者500例,按照血清碱性磷酸酶三分位分组,分析血清碱性磷酸酶水平和血管内皮功能(通过应变仪体积描记法评估)可能存在的关联。结果:血管对乙酰胆碱的最大反应与碱性磷酸酶水平呈负相关(r=一0.55,P〈0.01),该相关性独立于人口和传统危险因素,如体质量指数,估算的肾小球滤过率,血清磷和钙,C反应蛋白和蛋白尿。 | 刘莉 叶鹏 Perticone F Perticone M Maio R Sciacqua A Andreucci M Tripepi G Corrao S Mallamaci F Sesti G Zoccali C | 2015 | 中华高血压杂志2015，23，8： | 1 |
| 13 | Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients显示文摘 | Sciacqua A Scozzafava A | 2007 | Hypertension2007，25，： | 1 |
| 14 | A comparison of vaginal,laparoscopic-assisted vaginal,and minilaparotomy hysterectomies for enlarged myomatous uteri显示文摘 | Sesti F Calonzi F Ruggeri V | 2008 | Int J Gynaecol Obstet2008，103，3： | 1 |
| 15 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) 显示文摘 | Buse J B Rosenstock J Sesti G | 2009 | Lancet2009，374，9683： | 1 |
| 16 | Isobaric gasless laparoscopy versus minilaparotomy in uterine myomeetomy : a randomized trial 显示文摘 | Sesti F Capobianco F Capozzolo T | 2008 | Surg Endosc2008，22，4： | 1 |
| 17 | Defects of the insulin receptor substrate (IRS) system in human metabolic disorders显示文摘 | Sesti G Federici M Hribal ML | 2001 | FASEB J2001，15，12： | 1 |
| 18 | Pregnancy outcome after loop electrosurgical excision procedure for cervical intra-epithelial neoplasia 显示文摘 | Frega A Sesti F De Sanctis L | 2013 | Int J Gynecol Obstet2013，122，2： | 1 |
| 19 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes:a 26-week randomised,parallel-group,multinational,open-label trial(LEAD-6)显示文摘 | Buse JB Rosenstock J Sesti G | 2009 | Lancet2009，374，9683： | 1 |
| 20 | A polymorphism at IGF1 lo- cus is associated with carotid intima media thickness and endotheli- urn-dependent vasodilatation 显示文摘 | Sesti G Marmino GC Andreozzi F | 2014 | Atherosclerosis2014，232，1： | 1 |
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