|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia显示文摘 | Roland Boij Judit Svensson Kristina Nilsson‐Ekdahl Kerstin Sandholm Tomas L. Lindahl Elzbieta Palonek Mats Garle G?ran Berg Jan Ernerudh Maria Jenmalm Leif Matthiesen | 2012 | Am J Reprod Immunol2012，，3： | 2 |
| 3 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 4 | Within-Plant Distribution and Sampling of Single and Mixed Infestations of Bemisia tabaci and Trialeurodes vaporariorum ( Homoptera : Aleyrodidae) in Winter Tomato Crops显示文摘 | Judit A Ramon A Rosa G | 2006 | Journal of Economic Entomology2006，99，2： | 1 |
| 5 | Review, Thermal water in resources in carbonate rock aquifers显示文摘 | NICO G JUDIT M S ANITA E | 2010 | Hydrogeolo- gy Journal2010，18，6： | 1 |
| 6 | Comparison of propofol and etomidate re- garding impact on seizure threshold during electroconvulsive thera py in patients with schizophrenia显示文摘 | Gdbor G Judit T Zslot I | 2007 | Neuropsychopharmcol Hung2007，9，3： | 1 |
| 7 | Cellular control of gene expression by T-type cyclin/CDK9 complexes显示文摘 | GRAN A X | 2004 | Gene2004，337，： | 1 |
| 8 | Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma显示文摘 | Marta Hegyi ágnes Gulácsi Edit Cságoly Katalin Csordás Olivér Eipel Dániel Erdélyi Judit Müller Karolina Nemes Orsolya Lautner-Csorba Gábor Kovács | 2012 | Journal of Cancer Research and Clinical Oncology2012，，10： | 1 |
| 9 | Metal uptake by woodlice in urban soils显示文摘 | Judit G Julita M Andrew H | 2000 | Ecotoxicology and Environmental Safety2000，69，1： | 1 |
| 10 | Comprehensive Functional Assessment of MLH1 Variants of Unknown Significance显示文摘 | Ester Borràs Marta Pineda Angela Brieger Inga Hinrichsen Carolina Gómez Matilde Navarro Judit Balma?a Teresa Ramón y Cajal Asunción Torres Joan Brunet Ignacio Blanco Guido Plotz Conxi Lázaro Gabriel Capellá | 2012 | Human Mutation2012，，1： | 1 |
| 11 | ComParison of ProPofol andetomidate regarding imPact on seizure threshold during e-lectroconvulsive theraPy in Patients with schizoPhrenia显示文摘 | Gabor G Judit T Zslot I | 2007 | NeuroPsychoPharmacol Hung2007，9，3： | 1 |
| 12 | Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis显示文摘瞄准:与溃疡的 culitis (UC ) 并且与健康控制题目相比在成年病人决定血浆肉毒碱酉旨侧面。方法:用 ESI 三倍的四极双人脚踏车团分光术,肉毒碱酉旨侧面与 UC 和 44 匹配年龄、匹配性的健康控制在 44 个病人被测量。结果:在免费肉毒碱与 UC 和健康控制在病人之间铺平的 fasting 没有有效差量。禁食 propionyl-(0.331 +/- 0.019 对 0.392 +/- 0.017 micromol/L ) , butyryl-(0.219 +/- 0.014 对 0.265 +/- 0.012 ) ,并且 isovalerylcarnitine (0.111 +/- 0.008 对 0.134 +/- 0.008 ) 层次在 UC 病人被减少。由对比,octanoyl-的水平( 0.147 +/- 0.009 对 0.114 +/- 0.008 ),decanoyl-( 0.180 +/- 0.012 对 0.137 +/- 0.008 ),myristoyl-( 0.048 +/- 0.003 对 0.039 +/- 0.003 ),palmitoyl-( 0.128 +/- 0.006 对 0.109 +/- 0.004 ),palmitoleyl-( 0.042 +/- 0.003 对 0.031 +/- 0.002 )并且 oleylcarnitine ( 0.183 +/- 0.007 对 0.163 +/- 0.007 ;P <
0.05 在所有比较) 与 UC 在病人被增加。结论:我们的数据在 UC 病人建议肉毒碱酉旨的选择参与,可能由于他们的改变的新陈代谢。 | Judit Bene Katalin Komlósi Viktória Havasi Gábor Talián Beáta Gasztonyi Krisztina Horváth Gyula Mózsik Béla Hunyady Béla Melegh Mária Figler | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 13 | Comparison of propofol and etomidate regarding impact on seizure threshold during electroconvulsive ther- apy in patients with schizophrenia 显示文摘 | Gabor G Judit T Zsolt I | 2007 | Neuropsychopharrnacol Hung2007，9，3： | 1 |
| 14 | Use of Phytoplankton Assemblages for Monitoring Ecological Status of Lakes within the Water Framework Directive: The Assemblage Index显示文摘 | Judit Padisák Gábor Borics István Grigorszky éva Soróczki-Pintér | 2006 | Hydrobiologia2006，，1： | 1 |
| 15 | Increased nitric oxide levels as an early sign of premature aging in diabetes显示文摘 | Krisztián Stadler Veronika Jenei Gábor von B?lcsházy Anikó Somogyi Judit Jakus | 2003 | Free Radical Biology and Medicine2003，，10： | 1 |
| 16 | Clinico-Pathological Particularities of the Shock-Related Pancreatitis显示文摘 | Judit K Simona G Janos J | 2012 | Pathol Oncol Res2012，18，4： | 1 |
| 17 | The Role of ABC Transporters in Drug Resistance,Metabolism and Toxicity显示文摘 | Péter K Judit C | 2004 | Current Drug Delivery2004，，1： | 1 |
| 18 | Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma显示文摘 | Márta Csire Gábor Mikala Mónika Pet? Judit Jánosi Attila Juhász Attila Tordai János Jákó Gyula Domján János Dolgos Gy?rgy Berencsi István Vályi‐Nagy | 2007 | FEMS Immunology & Medical Microbiology2007，，： | 1 |
| 19 | H Lei, W Biegel, J Schubert, W Zander, Ch Buchal,The growth of MgO buffer layers on sapphire for the epitaxy of BaTiO3 optical thin films显示文摘 | Judit G Lisoni M Siegert C | 2001 | Thin Solid Films2001，，12： | 1 |
| 20 | Prevalence of SLC22A4 1672T and SLC22A5 ?207C combination defined TC haplotype in Hungarian ulcerative colitis patients显示文摘 | Lili Magyari Judit Bene Katalin Komlósi Gábor Talián Bernadett Faragó Veronika Cs?ngei Luca Járomi Enik? Sáfrány Csilla Sipeky Lilla Lakner Márta Varga Beáta Gasztonyi Béla Melegh | 2007 | Pathology & Oncology Research2007，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员