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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Long-term rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric IOL:a 1.5-year follow-up显示文摘AIM:To evaluate the rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric intraocular lenses(IOL) over a 1.5-year follow-up period.Data from the 6-month follow-up study have been previously reported.METHODS:Forty eyes of 26 cataract patients(mean age:72.8±7.9y) with pre-existing corneal astigmatism of 1.0 to 2.6 D were enrolled in the study.Mean axial length was 23.17±0.88 mm.Main outcome measures after implantation of the Torica-a A IOL(Human Optics) were IOL rotational stability,subjective refraction,astigmatism correction,uncorrected and corrected distance visual acuity(UDVA,CDVA).RESULTS:There was no significant change in the parameters evaluated between the 6-month and 1.5-year follow-ups.At last visit,mean absolute IOL rotation(objective method) was 1.81°±1.87°(range 0.00° to 7.20°) with 78.6% of eyes having IOL rotation <3°,92.9% of eyes <5° and 100% of eyes <8°.No patient required secondary IOL repositioning during the course of the study.Mean residual refractive cylinder was-0.60±0.40 D.There was a significant reduction in the magnitude of the J0 vector postoperatively(P<0.0001) with a mean absolute change of 0.76±0.40 D.The mean J45 vector was close to zero preoperatively and postoperatively and didn't change significantly(P=0.28).Mean monocular UDVA and CDVA was 0.09±0.12 log MAR and-0.01±0.12 log MAR,respectively.No treatment with Nd:YAG laser was required.CONCLUSION:The Torica-a A IOL shows good and stable visual performance and rotational stability over a 1.5-year follow-up period. | Balázs Gyongyossy Paul Jirak Ulrich Schonherr | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 7 |
| 3 | The pharmacist as a health consultant - ten years later显示文摘 | Jirak | 1990 | Drug Intell Clin Pharm1990，24，： | 1 |
| 4 | N-3 polyunsaturated fatty acids in psychiatric diseases: mechanisms and clinical data显示文摘 | Zeman M Jirak R Vecka M | 2012 | Neuro Endocrinol Lett2012，33，8： | 1 |
| 5 | Effects of MRI acquisition parameter variations and protocol heterogeneity on the results of texture analysis and pattern discrimination: An appli- cation-oriented study显示文摘 | Mayerhoefer ME Szomolanyi P Jirak D | 2009 | Med Phys2009，36，4： | 1 |
| 6 | Lesion evolution after gamma knife irradiation observed by magnetic resonance imaging 显示文摘 | JIRAK D NAMESTKOVA K HERYNEK V | 2007 | Int J Radiat Biol2007，83，4： | 1 |
| 7 | Texture analysis of human liver显示文摘 | Jirak D Dezortova M Taimr P | 2002 | Magn Reson Imaging2002，15，1： | 1 |
| 8 | Leptin,adiponectin,leptin to adiponectin ratio and insulin resistance in depressive women显示文摘 | Zeman M Jirak R Jachymova M | | 0，，： | 1 |
| 9 | Metabolite and diffusion changes in the rat brain after Leksell Gamma Knife irradiation 显示文摘 | Herynek V Burian M Jirak D | 2004 | Magn Reson Med2004，52，： | 1 |
| 10 | Satellite and radar survey of mesoscale convective system development显示文摘 | JIRAK I L COTTON W R MCANELLY R L | 2003 | Mon Wea Rev2003，131，10： | 1 |
| 11 | Satellite and radar sur vey of mesoscale conw, ctive system development显示文摘 | Jirak I L Cotton W R McanellyR L | 2003 | Mon Wea Rev2003，131，10： | 1 |
| 12 | Texture Analysis of Human Liver显示文摘 | Jirak D Dezotova M Taimr P | 2002 | Magn Reran Imaging2002，15，1： | 1 |
| 13 | Satellite and Radar Survey of Mesoscale Convective System Development显示文摘 | Jirak I L Cotton W R McAnelly R L | 2003 | Mon Weather Rev2003，131，10： | 1 |
| 14 | Satellite and radar survey of mesoscale convective system development显示文摘 | Jirak I L Cotton W R McAnelly R L | 2003 | Mon Wea Rev2003，131，10： | 1 |
| 15 | Satellite and radar survey of meso- scale convective system development 显示文摘 | Jirak I L Cotton W R McAnelly R L | 2003 | Mon Wea Rev2003，131，10： | 1 |
| 16 | Leptin, adipo- nectin, leptin to adiponectin ratio and insulin resistance in depre- ssive women显示文摘 | ZEMAN M JIRAK R JACHYMOVA M | 2009 | Neuro Endoerinol Lett2009，30，3： | 1 |
| 17 | MRI of transplanted pancreatic islets显示文摘 | Jirak D Kriz J Herynek V | | 0，，： | 1 |
| 18 | Magnetic resonance imaging of pancreatic islets in tolerance and rejection显示文摘 | Kriz J Jirak D Girman P | | 0，，： | 1 |
| 19 | Lcptin,adiponcctin,〗eptin to adiponectin ratio and insulin resistance in depressivewomen显示文摘 | Zeman M Jirak R Jachymova M | 2009 | Neuro Endocrinol Lett2009，30，： | 1 |
| 20 | 显示文摘 | Sedmidubsky D Jirak Z Hejtmanek J | 2004 | J Magn Magn Mater2004，，： | 1 |
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