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| 1 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 2 | Heat flow and its coalbed gas effects in the central-south area of the Huaibei coalfield, eastern China显示文摘Based on an analysis of the present geo-temperature field and the thermal conductivity (K) of 62 samples from the central-south area of the Huaibei coalfield in eastern China, we calculated the heat flow and plotted its distribution map. The results show that the average heat flow in the research area is about 60 mW/m2. It is different from other major energy basins in the North China Plate, but has close relationship with the regional geology and the deep geological setting. The heat flow is comparatively higher in the southeastern, central, and northwestern areas than in the northeastern and southwestern areas. The geo-temperature distribution map of the bottom interface of the Permian coal measure was drawn by calculating its embedding depth and geo-temperature gradients. Finally, the present gas generation condition of the Permian coal measure is discussed by associating with the temperature condition, the vitrinite reflectance (Ro), the metamorphism of coal and tectonic-burial evolution. The study indicates all present characters of the Permian coal measure, such as lower present temperature, higher Ro value, middle-high rank coals, and uplift and extension events after the coal measure sediment, are favorable for the generation of secondary biogenic gas, but not thermogenic gas or primary biogenic gas. | TAN JingQiang JU YiWen ZHANG WenYong HOU QuanLin TAN YongJie | 2010 | Science China Earth Sciences2010，53，5： | 9 |
| 3 | The Epitope Study on the SARS-CoV Nucleocapsid Protein显示文摘The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA),the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins,whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS. | Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi Zhou, Xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng Zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 9 |
| 4 | Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization显示文摘This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of recombinant DNA(pCCMp24) and recombinant attenuated vaccinia virus Tian Tan(rddVTT-CCMp24).Intramuscular immunization was performed on days 0(prime) and 21(boost).The immunogenicity of the vaccine schedules was determined by measuring human immunodeficiency virus(HIV)-specific binding antibody levels and cytokine(interleukin-2 and interleukin-4) concentrations in peripheral blood,analyzing lymphocyte proliferation capacity against HIV epitopes and CD4 + /CD8 + cell ratio,and monitoring interferon-gamma levels at different times post-immunization.The results showed that pCCMp24,rddVTT-CCMp24 and their prime-boost immunization induced humoral and cellular immune responses.The pCCMp24/rddVTT-CCMp24 immunization strategy increased CD8 + T cells and induced more IFN-γ-secreting cells compared with single-shot rDNA.The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides.These results demonstrated that prime-boost immunization with rDNA and rddVTT-CCMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations,especially IFN-γ response,providing a basis for further studies. | LIU CunXia DU ShouWen LI Chang WANG YuHang WANG MaoPeng LI Yi YIN RongLan LI Xiao REN DaYong QIN YanQing REN JingQiang JIN NingYi | 2013 | Science China(Life Sciences)2013，56，6： | 7 |
| 5 | Soil heavy metal pollution from Pb/Zn smelting regions in China and the remediation potential of biomineralization显示文摘Smelting activities pose serious environmental problems due to the local and regional heavy metal pollution in soils they cause. It is therefore important to understand the pollution situation and its source in the contaminated soils. In this paper, data on heavy metal pollution in soils resulting from Pb/Zn smelting(published in the last 10 years) in China was summarized. The heavy metal pollution was analyzed from a macroscopic point of view. The results indicated that Pb, Zn, As and Cd were common contaminants that were present in soils with extremely high concentrations. Because of the extreme carcinogenicity, genotoxicity and neurotoxicity that heavy metals pose, remediation of the soils contaminated by smelting is urgently required. The primary anthropogenic activities contributing to soil pollution in smelting areas and the progressive development of accurate source identification were performed. Due to the advantages of biominerals, the potential of biomineralization for heavy metal contaminated soils was introduced. Furthermore, the prospects of geochemical fraction analysis, combined source identification methods as well as several optimization methods for biomineralization are presented, to provide a reference for pollution investigation and remediation in smelting contaminated soils in the future. | Xinghua Luo Chuan Wu Yongcheng Lin Waichin Li Min Deng Jingqiang Tan Shengguo Xue | 2023 | Journal of Environmental Sciences2023，，3： | 5 |
| 6 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 7 | A practical method for identifying key factors in the distribution and formation of heavy metal pollution at a smelting site显示文摘Smelting activities are the main pathway for the anthropogenic release of heavy metals(HMs)into the soil-groundwater environment.It is vital to identify the factors affecting HMs pollution to better prevent and manage soil pollution.The present study conducted a comprehensive investigation of HMs in soil from a large abandoned Zn smelting site.An integrated approach was proposed to classify and quantify the factors affecting HMs pollution in the site.Besides,the quantitative relationship between hydrogeological characteristics,pollution transmission pathways,smelting activities and HMs pollutionwas established.Results showed that the soils were highly contaminated by HMs with a pollution index trend of As>Zn>Cd>Pb>Hg.In identifying the pollution hotspots,we conclude that the pollution hotspots of Pb,As,Cd,and Hg present a concentrated distribution pattern.Geo-detector method results showed that the dominant driving factors for HMs distribution and accumulation were the potential pollution source and soil permeability.Additionally,the main drivers are variable for different HMs,and the interaction among factors also enhanced soil HMs contamination.Our analysis illustrates how the confounding influences from complex environmental factors can be distilled to identify key factors in pollution formation to guide future remediation strategies. | Jiaqing Zeng Wenshun Ke Min Deng Jingqiang Tan Chuxuan Li Yizhi Cheng Shengguo Xue | 2023 | Journal of Environmental Sciences2023，，5： | 3 |
| 8 | Relationships between the sound speed ratio and physical properties of surface sediments in the South Yellow Sea显示文摘Building empirical equations is an effective way to link the acoustic and physical properties of sediments.These equations play an important role in the prediction of sediments sound speeds required in underwater acoustics.Although many empirical equations coupling acoustic and physical properties have been developed over the past few decades,further confirmation of their applicability by obtaining large amounts of data,especially for equations based on in situ acoustic measurement techniques,is required.A sediment acoustic survey in the South Yellow Sea from 2009 to 2010 revealed statistical relationships between the in situ sound speed and sediment physical properties.To improve the comparability of these relationships with existing empirical equations,the present study calculated the ratio of the in situ sediment sound speed to the bottom seawater sound speed,and established the relationships between the sound speed ratio and the mean grain size,density and porosity of the sediment.The sound speed of seawater at in situ measurement stations was calculated using a perennially averaged seawater sound speed map by an interpolation method.Moreover,empirical relations between the index of impedance and the sound speed and the physical properties were established.The results confirmed that the existing empirical equations between the in situ sound speed ratio and the density and porosity have general suitability for application.This study also considered that a multiple-parameter equation coupling the sound speed ratio to both the porosity and the mean grain size may be more useful for predicting the sound speed than an equation coupling the sound speed ratio to the mean grain size. | Guanbao Li Jingqiang Wang Xiangmei Meng Baohua Liu Guangming Kan Guozhong Han Qingfeng Hua Yanliang Pei Lei Sun | 2021 | Acta Oceanologica Sinica2021，40，4： | 2 |
| 9 | Pathological Models of EXCCCII and Its Applications in Oscillator Synthesis显示文摘After giving six different forms of the extra X second-generation current-controlled conveyor(EXCCCII),pathological models of six EXCCCIIs are found by the nodal admittance matrix(NAM)expansion approach.Furthermore,these ideal pathological circuit models are employed and 36 Wien oscillators and 8 third-order quadrature oscillators are synthesized by the NAM expansion.The hand analysis and computer analysis are introduced to prove the synthesized circuits are correct and effective. | LI Yongan HOU Jingqiang | 2021 | Wuhan University Journal of Natural Sciences2021，26，1： | 2 |
| 10 | Three-dimensional structure of the hepatitis B core antigen particle truncated at residue 154显示文摘The three-dimensional structure of recombinant hepatitis B core antigen(HBcAg) particles truncated at residue 154(HBcAg-154) was determined to 7.8 ? resolution by cryo-electron microscopy(cryoEM) and computer reconstruction.The capsid of HBcAg-154 is mainly constituted by α-helical folds,highly similar to that of HBcAg-149.The C-terminal region between residues 155 and 183 of the core protein is more crucial to the encapsidation of RNA,and the short C-terminal tail of HBcAg-154 results in a nearly empty capsid. | LIU ShuYu HE Jian LI KunPeng DAI AGuang CAI ChangJie ZHANG JingQiang | 2011 | Science China(Life Sciences)2011，54，2： | 2 |
| 11 | Damage-Monitoring Forward Equivalent-model Construction of Rosette Eddy Current Sensors显示文摘结构损伤监测对于保证结构安全是极其重要的。针对金属螺栓连接结构中螺栓孔位置处的裂纹损伤定量监测需求,在Goldfine等人的基础之上,该文提出一种花萼状涡流传感器,构建了传感器损伤监测正向等效模型并通过搭建实验装置验证损伤监测正向等效模型准确性并进行误差分析。相对于传统的多层导电结构谐波涡流场的积分/级数解析模型,构建的损伤监测正向等效模型考虑了在高频激励下导线电流密度分布的集肤效应,并可用于互感式涡流传感器建模。实验结果表明:对测量结果经空气标定后,传感器贴于2A12-T4标准试件表面时的模型计算结果和实验结果较为吻合,第1、2和3感应通道的幅值比量模型计算结果误差随频率变化均在10%以内,第4感应通道的幅值比量模型计算结果误差随频率变化在15%以内。 | DING Hua HE Yuting JIAO Shenbo DU Jingqiang | 2013 | 中国电机工程学报2013，33，9： | 2 |
| 12 | Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers显示文摘Breast cancer is a heterogeneous disease.In particular,triple-negative breast cancer(TNBC)comprises various molecular subgroups with unclear identities and currently has few targeted treatment options.Our previous study identified protein C receptor(Procr)as a surface marker on mammary stem cells(MaSCs)located in the basal layer of the normal mammary gland.Given the possible connection of TNBC with basal layer stem cells,we conducted comparative analyses of Procr in breast cancers of mouse and human origin.In mouse mammary tumors,we showed that Procr+cells are enriched for cancer stem cells(CSCs)in Wnt1 basal-like tumors,but not in Brea basal-like tumors or PyVT luminal tumors.In human cancers,PROCR was robustly expressed in half of TNBC cases.Experiments with patient-derived xenografts(PDXs)revealed that PROCR marks CSCs in this discrete subgroup(referred to as PROCR+TNBC).Interfering with the function of PROCR using an inhibitory nanobody reduced the CSC numbers,arrested tumor growth and prevented rapid tumor recurrence.Our data suggest a key role of MaSC in breast tumorigenesis.Moreover,our work indicates that PROCR can be used as a biomarker to stratify TNBC into clinically relevant subgroups and may provide a novel targeted treatment strategy for this clinically important tumor subtype. | Daisong Wang Xin Hu Chunye Liu Yingying Jia Yiqin Bai Cheguo Cai Jingqiang Wang Lanyue Bai Ruikai Yang ChangDong Lin Yi-Rong Liu Shan Li Feng Qiao Ling Yao Li Chen Gaoxiang Ge Hai Jiang Dianfan Li Lin Li JianFeng Chen Zhi-Ming Shao Yi Arial Zeng | 2019 | Cell Research2019，29，10： | 2 |
| 13 | Distributions and vertical variation patterns ofsound speed of surface sediments in South China Sea显示文摘 | WANG JINGQIANG GUO CHANGSHENG HOU ZHENGYU 2014 | 2014 | Journal of Asian Earth Sciences2014，89，： | 1 |
| 14 | Types of Ecological Revetments in Hydraulic Engineering显示文摘Compared with traditional bank protection, ecological revetments, as a new type of bank protection, can ensure the sustainable and healthy development of river ecology and has broad application prospects. In this paper, the design principles for ecological revetments and the factors that need to be considered in the selection of revetment plants were summarized; and the types of ecological revetments commonly used in water conservancy projects were summarized and classified according to the proportion of natural materials in revetment materials through domestic and foreign research and engineering examples, and their applicable scope and relevant merits were introduced. In conclusion, ecological revetments should get rid of its own limitations in the practical application process, and the river regulation scheme and revetment type should be selected comprehensively and flexibly combined with the status quo. | RONG Yunjie LIU Jingqiang LIU Qianyu | 2018 | Journal of Landscape Research2018，10，2： | 1 |
| 15 | Hydrophobic coat- ing of polyaniline-poly(propylene oxide ) copolymer tbr direct immer- sion solid phase microextraction of earbamate pesticides显示文摘 | Ai Youhong Zhang Jingqiang Zhao Faqiong | 2015 | Journal of Chromatogra#hyA2015，1407，： | 1 |
| 16 | An optimal generation rescheduling approach for transient stability enhancement 显示文摘 | Fang Dazhong Yang Xiaodong Sun Jingqiang | 2007 | IEEE Transactions on Power Systems2007，22，1： | 1 |
| 17 | A novel aryl amide-bridged ladderlike polymethylsiloxane synthesized by amido h-bonding self-assembled template显示文摘 | TANG HUADONG SUN JIN JIANG JINGQIANG | 2002 | J Am Chem Soc2002，124，10： | 1 |
| 18 | Study on the optimum position of F - EMS in billet of 82B 显示文摘 | Gong Wenxu He Jianzhe Liu Jingqiang | 2007 | Tianjin Metallurgy2007，，4： | 1 |
| 19 | Core-shell particles with an acrylate polyurethane core as tougheners for epoxy resins 显示文摘 | Shen JingQiang ZhangYaFeng Qfu JinDong | 2004 | Journal of Materials Science2004，39，： | 1 |
| 20 | An optimal generation rescheduling approach for transient stability enhancement显示文摘 | Fang Dazhong Yang Xiaodong Sun Jingqiang | 2007 | IEEE Transactions on Power Systems2007，22，1： | 1 |
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