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| 1 | The Canonical Correlation Analysis on Semen Quality and Serum Heavy Metals in Chinese Young Men显示文摘Objective To explore the correlation between serum heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 562 male vomunteers who had undergone premarital physical examination in maternal and children health centers in 7 provinces in China.Results Results from Spearman rank correlation analysis (partial variable: region) show that serum lead and cadmium are negatively related to percentage of morphological normal sperm, but canonical correlation between semen quality and serum heavy metal are not significant. Canonical correlation analysis among the subjects from Guizhou shows cadmium is harmful to sperm morphology. In Henan, furthermore, results show lead and cadmium could negatively affect sperm viability and morphology.Conclusion Among all study subjects, canonical correlation between semen quality and serum heavy metal were not significant; however, results in some region showed serum cadmium and lead might be harmful to sperm quality. | Jun-qingWU Cui-lingLIANG Er-shengGAO Jian-guoTAO Qiu-yingYANG XiaoXU Wen-juanCAI JianGUO FengTANG JiangZHU Zhan-haiFU Yin-meiDU | 2003 | Journal of Reproduction and Contraception2003，14，2： | 2 |
| 2 | The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles显示文摘 | ApiwatChompoosor KrishnenduSaha Partha S.Ghosh Dylan J.Macarthy Oscar R.Miranda Zheng‐JiangZhu Kathleen F.Arcaro Vincent M.Rotello | 2010 | Small2010，，20： | 1 |
| 3 | The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles显示文摘 | ApiwatChompoosor KrishnenduSaha Partha S.Ghosh Dylan J.Macarthy Oscar R.Miranda Zheng‐JiangZhu Kathleen F.Arcaro Vincent M.Rotello | 2010 | Small2010，，20： | 1 |
| 4 | Retrofit of 350-MW Supercritical Boiler Based on the Analysis on Exhaust Gas Temperature显示文摘Since the first batch of 350-MW supercritical utility boilers was put into operation, the exhaust flue gas temperature of the boilers has always been higher than the designed value. The main reason is that the heat absorbed by the air heater is not sufficient. In Huaneng Dongfang Power Plant, the exhaust flue gas temperature is lowered through modifications to the economizer and the air heater. The experimental results reveal that every year, each boiler could save 3 850 tons of standard coal and reduce 85 tons of SO2 and 9 000 tons of CO2 respectively after retrofit. | Qin Jiangzhu Huaneng Dongfang Power Plant Wang Shichang | 2011 | Electricity2011，22，5： | 0 |
| 5 | An open-label evaluation of safety and tolerability of coformulated bictegravir/emtricitabine/tenofovir alafenamide for post-exposure prophylaxis following potential exposure to human immunodeficiency virus-1显示文摘Background: Single-tablet regimen (STR) provides a convenient once-daily regimen for the prevention of human immunodeficiency virus (HIV) infection. Here, we investigated the safety and tolerability of coformulated bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) as a three-drug, STR for post-exposure prophylaxis (PEP) in Chinese individuals.Methods: This was a prospective, open-label, single-arm trial conducted in a sexually transmitted diseases and acquired immunodeficiency syndrome clinic of a tertiary hospital in Beijing, China. Adults requiring PEP were prescribed BIC/FTC/TAF one pill once a day for 28 days. Clinical and laboratory data were collected and analyzed at baseline, weeks 2, 4, 8, 12, and 24.Results: Of 112 participants enrolled in the study, 109 (97.3%) were male and the mean age was 30 ± 8 years. PEP completion was 96.4% (95% confidence interval: 91.1-99.0%). Two participants stopped PEP after 2 days because the source partner was identified as HIV uninfected. One participant was excluded due to hepatitis B virus infection according to the exclusion criteria. One discontinued due to the participant’s decision. No participant acquired HIV through week 24. Adherence was 98.9% (standard deviation [SD]: 3.3%) by self-reporting and 98.5% (SD: 3.5%) by pill count. Only five participants experienced mild clinical adverse events attributed to the study drug (including headache, diarrhea, and nausea) and four participants had elevated serum creatinine (grade 1).Conclusions: A once daily, STR of BIC/FTC/TAF used as PEP was safe and well-tolerated with a high rate of completion and adherence in Chinese. BIC/FTC/TAF may be a good option for PEP. | An Liu Ruolei Xin Hongwei Zhang Lili Dai Ruojun(Esther)Wu Xi Wang Aixin Li Wei Hua Jianwei Li Ying Shao Yue Gao Zhangli Wang Jiangzhu Ye Gulimila A bu dou re xi ti Zaicun Li Lijun Sun | 2022 | Chinese Medical Journal2022，135，22： | 0 |
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