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| 1 | M1 muscarinic acetylcholine receptor in Alzheimer's disease显示文摘The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease(AD). Muscarinic acetylcholine receptors(mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes(M1–M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment. | Shangtong Jiang Yanfang Li Cuilin Zhang Yingjun Zhao Guojun Bu Huaxi Xu Yun-Wu Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 10 |
| 2 | Moving finite element methods for time fractional partial differential equations显示文摘With the aim of simulating the blow-up solutions, a moving finite element method, based on nonuniform meshes both in time and in space, is proposed in this paper to solve time fractional partial differential equations (FPDEs). The unconditional stability and convergence rates of 2-α for time and r for space are proved when the method is used for the linear time FPDEs with α-th order time derivatives. Numerical examples are provided to support the theoretical findings, and the blow-up solutions for the nonlinear FPDEs are simulated by the method. | JIANG YingJun MA JingTang | 2013 | Science China Mathematics2013，56，6： | 9 |
| 3 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 4 | Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication显示文摘Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement results.Therefore, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing equalization.As far as we know, this is the highest data rate for an LED-based UVLC system. | YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU JUNLIN LIU FENGYI JIANG NAN CHI | 2019 | Photonics Research2019，7，9： | 7 |
| 5 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 6 | Development of matrix solid-phase dispersion method for the extraction of short-chain chlorinated paraffins in human placenta显示文摘Chlorinated paraffins(SCCPs) are widely used worldwide, and they can be released into the environment during their production, transport, usage and disposal, which pose potential risks for human health. In this work, an efficient, reliable and rapid pretreatment method based on matrix solid-phase dispersion(MSPD) was developed for the analysis of short-chain CPs(SCCPs) in human placenta by gas chromatograph-electron capture negative ion low-resolution mass spectrometry(GC-ECNI-LRMS) and gas chromatography–quadrupole time-of-flight mass spectrometry(GC–QTOF-HRMS). The MSPD-relevant parameters including dispersing sorbent,sample-to-sorbent mass ratio, and elution solvent were optimized using the orthogonal test.Silica gel was found to be the optimal dispersing sorbent among the selected matrices. Under the optimal conditions, 44% acidic silica gel can be used as the co-sorbent to remove lipid and eluted by the mixture of hexane and dichloromethane(7:3, V/V). The spiked recoveries of the optimized method were 77.4% and 91.4% for analyzing SCCPs in human placenta by GC-ECNI-LRMS and GC–QTOF-HRMS, and the corresponding relative standard deviations were10.2% and 5.6%, respectively. The method detection limit for the total SCCPs was 36.8 ng/g(dry weight, dw) and 19.2 ng/g(dw) as measured by GC-ECNI-LRMS and GC–QTOF-HRMS,respectively. The concentrations of SCCPs in four human placentas were in the range of | Ying Wang Wei Gao Jing Wu Huijin Liu Yingjun Wang Yawei Wang Guibin Jiang | 2017 | Journal of Environmental Sciences2017，29，12： | 4 |
| 7 | A monotone finite volume method for time fractional Fokker-Planck equations显示文摘We develop a monotone ?nite volume method for the time fractional Fokker-Planck equations and theoretically prove its unconditional stability. We show that the convergence rate of this method is of order 1 in the space and if the space grid becomes suffciently ?ne, the convergence rate can be improved to order 2.Numerical results are given to support our theoretical ?ndings. One characteristic of our method is that it has monotone property such that it keeps the nonnegativity of some physical variables such as density, concentration,etc. | Yingjun Jiang Xuejun Xu | 2019 | Science China Mathematics2019，62，4： | 3 |
| 8 | ON A MOVING MESH METHOD FOR SOLVING PARTIAL INTEGRO-DIFFERENTIAL EQUATIONS显示文摘这份报纸开发并且分析一个动人的网孔为解决部分 integro 微分的方程的有限差别方法。首先,并列转变印射的时间依赖者被 piecewise 接近在空间和 piecewise 的二次的多项式线性功能及时。然后,方程的记忆术语用动人的网孔途径被设计的一个有效方法到 discretize。在里面每次切,被积函数的简单 piecewise 常数近似被使用,并且因此,照被构造记忆术语。为空间的中央有限差别计划和在时间的向后的 Euler 计划被使用。纸证明照错误的累积一致地被围住并且方法的集中及时是在空间和第一份订单的第二份订单。数字实验被执行证实理论预言。[从作者抽象] | Jingtang Ma Yingjun Jiang Kaili Xiang | 2009 | Journal of Computational Mathematics2009，27，6： | 3 |
| 9 | Monodomain Liquid Crystals of Two-Dimensional Sheets by Boundary-Free Sheargraphy显示文摘Eliminating topological defects to achieve monodomain liquid crystals is highly significant for the fundamental studies of soft matter and building long-range ordered materials.However,liquid crystals are metastable and sensitive to external stimuli,such as flow,confinement,and electromagnetic fields,which cause their intrinsic polycrystallinity and topological defects.Here,we achieve the monodomain liquid crystals of graphene oxide over 30 cm through boundary-free sheargraphy.The obtained monodomain liquid crystals exhibit large-area uniform alignment of sheets,which has the same optical polarized angle and intensity.The monodomain liquid crystals provide bidirectionally ordered skeletons,which can be applied as lightweight thermal management materials with bidirectionally high thermal and electrical conductivity.Furthermore,we extend the controllable topology of two-dimensional colloids by introducing singularities and disclinations in monodomain liquid crystals.Topological structures with defect strength from−2 to+2 were realized.This work provides a facile methodology to study the structural order of soft matter at a macroscopic level,facilitating the fabrication of metamaterials with tunable and highly anisotropic architectures. | Min Cao Senping Liu Qingli Zhu Ya Wang Jingyu Ma Zeshen Li Dan Chang Enhui Zhu Xin Ming Yingjun Liu Yanqiu Jiang Zhen Xu Chao Gao | 2022 | Nano-Micro Letters2022，14，12： | 2 |
| 10 | Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic surgery显示文摘The aim of this paper is to summarize the methods of pancreaticojejunostomy in the pancreatic operation and to study the safety and feasibility of a new operative method called end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture to prevent fistula of pancreaticojejunostomy.Eight-three patients with pancreaticoduodenectomy in the 3rd Hospital,Jilin University from 2001 January to 2006 April were reviewed.The incidences of pancreatic fistula with different types of pancreaticojejunostomy were compared.The overall incidence rate of pancreatic fistula was 26.5%(22/83).No pancreatic fistula occurred in end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture.The incidence rate of the fistula following end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture was significantly lower than that of traditional end-to-end pancreaticojejunostomy[40%,(10/25),P<0.01]and end-to-side pancreaticojejunostomy[27.3%,(12/44),P<0.05],but no significant difference(P>0.05)between traditional end-to-end pancreaticojejunostomy and end-to-side pancreaticojejunostomy was discovered.End-to-end invagination pancreaticojejunostomy with circle discontinuous U suture has a definite effect on avoiding pancreatic fistula following pancreaticojejunostomy and is worth being recommended.But the cases were limited,so this method would still need to be observed and confirmed further in the future. | ZHANG Xuewen XUAN Wei JIANG Tao JI Degang YANG Yongsheng ZHANG Dan XIE Yingjun MENG Zihui ZHAO Jisheng | 2007 | Frontiers of Medicine2007，1，1： | 1 |
| 11 | An Integral Equation Method with High-Order Collocation Implementations for Pricing American Put Options 显示文摘 | MA Jingtang XIANG Kaili JIANG Yingjun | 2010 | International Journal of Economics and Finance2010，2，4： | 1 |
| 12 | Moving mesh methods for blowup in reaction-diffusion equations with traveling heat source显示文摘 | Ma Jingtang Jiang YingJun | 2009 | Journal of Computational Physics2009，228，18： | 1 |
| 13 | Lithium-ion insertion kinetics of Na-doped Li2TiSiO5 as anode materials for lithium-ion batteries显示文摘Li2TiSiO5 receives much interest recently in lithium-ion battery anodes because of its attractive Liinsertion/extraction potential at 0.28 V(vs. Li+/Li), which bridges the potential gap between graphite and Li4 Ti5 O12. However, Li2TiSiO5 suffers from the low intrinsic electronic conductivity and sluggish Liion transfer kinetics. In this work, we report lithium-ion insertion kinetics of Li2TiSiO5 by Na doping,achieving high-rate capability. Rietveld refinement of X-ray diffraction results reveals that Na doping can enlarge the space of Li slabs, thus reducing the Li-ion transfer barrier and enhancing the Li-ion diffusion kinetics. According to first-principles calculations, Na doping can tune the band structure of Li2TiSiO5 from indirect to direct band, leading to improved electronic conductivity and electrochemical performance. In particular, the Na-doped Li2TiSiO5(Li1.95 Na(0.05)TiSiO5) electrode exhibits outstanding rate capability with a high capacity of 101 m A h g^(-1) at 5 A g^(-1) and superior cyclability with a reversible capacity of 137 m A h g^(-1) under 0.5 A g^(-1) over 150 cycles. | Yueni Mei Yuyu Li Fuyun Li Yaqian Li Yingjun Jiang Xiwei Lan Songtao Guo Xianluo Hu | 2020 | Journal of Materials Science & Technology2020，54，22： | 1 |
| 14 | Three-dimensional printing of graphene-based materials for energy storage and conversion显示文摘Developing high-performance energy storage and conversion(ESC)device relies on both the utilization of good constituent materials and rational design of assembly structure.Graphene-based materials,due to their superior properties like high electrical/thermal conductivity,large surface area,and unique optical properties,have been extensively reported for ESC applications.The emerging three-dimensional(3D)printing techniques,especially extrusion-based direct ink writing technique,have brought a revolutionary improvement in structure control accuracy and designing capability to graphene-based macro-assemblies,triggering a boost in functionalities and performances of graphene-based ESC devices.In these circumstances,understanding the very recent progress of 3Dprinted graphene materials and their design philosophy to bring new concepts for material designs and address the requirements for high-performance ESC devices are urgently important.In this review,we aim to outline recent developments in 3D printing of graphene-based materials and their applications in ESC applications.Basic requirements and theoretical analysis for preparation printable inks are discussed,as well as feasible GO ink preparation strategies in existing literatures.The representative explorations of 3D-printed graphenematerials in ESC applications like batteries,supercapacitors,solar steam generators,and electro-thermal conversion are also reviewed.This study attempts to provide a comprehensive overview of the progresses and limitations of present 3D printed graphenematerials,and seeks to enlighten the opportunities and orientations of future research in this field. | Yanqiu Jiang Fan Guo Yingjun Liu Zhen Xu Chao Gao | 2021 | SusMat2021，1，3： | 1 |
| 15 | High order finite element methods for time-fractional partial differential equations显示文摘 | Jiang Yingjun Ma Jingtang | 2011 | Journal of compu rational and Applied Mathematics2011，235，11： | 1 |
| 16 | A numerical test method of California bearing ratio on graded crushed rocks using particle flow modeling显示文摘In order to better understand the mechanical properties of graded crushed rocks(GCRs)and to optimize the relevant design,a numerical test method based on the particle flow modeling technique PFC2Dis developed for the California bearing ratio(CBR)test on GCRs.The effects of different testing conditions and micro-mechanical parameters used in the model on the CBR numerical results have been systematically studied.The reliability of the numerical technique is verified.The numerical results suggest that the influences of the loading rate and Poisson's ratio on the CBR numerical test results are not significant.As such,a loading rate of 1.0e3.0 mm/min,a piston diameter of 5 cm,a specimen height of15 cm and a specimen diameter of 15 cm are adopted for the CBR numerical test.The numerical results reveal that the CBR values increase with the friction coefficient at the contact and shear modulus of the rocks,while the influence of Poisson's ratio on the CBR values is insignificant.The close agreement between the CBR numerical results and experimental results suggests that the numerical simulation of the CBR values is promising to help assess the mechanical properties of GCRs and to optimize the grading design.Besides,the numerical study can provide useful insights on the mesoscopic mechanism. | Yingjun Jiang Louis Ngai Yuen Wong Jiaolong Ren | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，2： | 1 |
| 17 | Profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria: a retrospective study in China, 2014–2021显示文摘Background: In areas where malaria has been eliminated, delayed care-seeking and diagnosis of imported malaria are constant threats. This study aimed to describe the profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria in China.Methods: This retrospective study assessed surveillance data obtained from 2014 to 2021 in the Chinese provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, and Zhejiang, and Guangxi. Epidemiological characteristics were analyzed using descriptive statistics. Furthermore, factors associated with delayed care-seeking and diagnosis among imported malaria cases were identified using multivariate logistic regression.Results: Overall, 11.81% and 30.08% of imported malaria cases had delays in seeking care and diagnosis, respectively. During the study period, there was a decreasing trend in the proportion of imported malaria cases with delayed care-seeking (χ^(2) = 36.099,P < 0.001) and diagnosis (χ^(2) = 11.395,P = 0.001). In multivariate analysis, independent risk factors associated with delayed care-seeking include PLADs (Guangxi as reference), consultations in high-level facilities for the first medical visit, infections with non-Plasmodium falciparum species, and older age. However, PLADs (Guangxi as reference), the purpose of traveling (labour as reference), and infections with non-P. falciparum species increased the risk of delayed diagnosis. Delayed care-seeking (adjusted odds ratio: 1.79,P = 0.001) and diagnosis (adjusted odds ratio: 1.62,P = 0.004) were risk factors for severe disease development.Conclusions: Based on this study’s findings, we strongly advocate for improved access to quality healthcare to reduce the rate of misdiagnosis at the first visit. Infections caused by non-P. falciparum species should be highlighted, and more sensitive and specific point-of-care detection methods for non-P. falciparum species should be developed and implemented. In addition, education programs should be enhanced to reach target populations at risk of malaria infection. All these factors may reduce delayed care-seeking and diagnosis of imported malaria. | Tao Zhang Duoquan Wang Yingjun Qian Wei Ruan Ying Liu Jing Xia Hui Yan Yuan Sui Shenning Lu Xian Xu Jingjing Jiang Xiaofeng Lyu Shuqi Wang Shizhu Li Weidong Li | 2022 | Infectious Diseases of Poverty2022，11，6： | 1 |
| 18 | Moving mesh methods for blowup in reaction-diffusion equations with traveling heat source显示文摘 | Ma Jingtang Jiang Yingjun | 2009 | J Comput Phys2009，228，： | 1 |
| 19 | Numerical simulation of blowup in nonlocal reaction-diffusion equations using a moving mesh method显示文摘 | Ma Jingtang Jiang Yingjun Xiang Kaili | 2009 | J Comput Appl Math2009，230，： | 1 |
| 20 | Effect of Wnt5a on the function of SODI mutantNSC34 cells显示文摘Amyotrophic lateral sclerosis(ALS)is a motor neuron disease.SOD1 is the first gene to be identified in ALS.Our experiments revealed abnormal expression of Wnt5a in ALS transgenic mice.To clarify Wnt5a affects motor neuron degeneration in ALS,we constructed the overexpressed Wnt5a plasmid and silenced W nt5a siRNA,transfected SOD1 mutant NSC34 cells.The viability of cells were detected by MTS,proliferation of cells were detected by EdU and neurite length of cells were measured after inducing the neurite outgrowth by retinoic acid.After overexpressing Wnt5a,The viability of cells were increased at 48,72 h.and 96 h,the proliferation of cells were increased at 48 h,the length of neurite was increased at 48 h in the SOD1 mutant NSC34 cells,compared with control group. | Liu Jinmeng Gruan Yingjun Chen Yanchun Jiang Xin | 2021 | 解剖学杂志2021，44，S01： | 0 |
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