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| 1 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 2 | Evaluation of multi-cycle performance of chemical looping dry reforming using CO_2 as an oxidant with Fe–Ni bimetallic oxides显示文摘Chemical looping dry reforming(CLDR) is an innovative technology for CO_2 utilization using the chemical looping principle.The CLDR process consists of three stages,i.e.CH4 reduction,CO_2 reforming,and air oxidation.Spinel nickel ferrite(NiFe_2O_4) was prepared and its multi-cycle performance as an oxygen carrier for CLDR was experimentally investigated.X-ray diffraction(XRD) and Laser Raman spectroscopy showed that a pure spinel crystalline phase(NiFe_2O_4) was obtained by a parallel flow co-precipitating method.NiFe_2O_4was reduced into Fe-Ni alloy and wustite(Fe_xO) during the CH_4 reduction process.Subsequent oxidation of the reduced oxygen carrier was performed with CO_2 as an oxidant to form an intermediate state:a mixture of spinel Ni_(1-x)Fe_(2+x)O_4,Fe_(2+y)O_4 and metallic Ni.And CO was generated in parallel during this stage.Approximate 185 mL of CO was generated for 1 g spinel NiFe_2O_4 in a single cycle.The intermediate oxygen carrier was fully oxidized in the air oxidation stage to form a mixture of Ni_(1+x)Fe_(2-x)O_4 and Fe_2O_3.Although the original state of oxygen carrier(NiFe_2O_4) was not fully regenerated and agglomeration was observed,a good recyclability was shown in 10 successive redox cycles. | Zhen Huang Huanqi Jiang Fang He Dezhen Chen Guoqiang Wei Kun Zhao Anqing Zheng Yipeng Feng Zengli Zhao Haibin Li | 2016 | Journal of Energy Chemistry2016，25，1： | 4 |
| 3 | Different oxidation routes for lattice oxygen recovery of double-perovskite type oxides LaSrFeCoO6 as oxygen carriers for chemical looping steam methane reforming显示文摘Double-perovskite type oxide LaSrFeCoO_6(LSFCO) was used as oxygen carrier for chemical looping steam methane reforming(CL-SMR) due to its unique structure and reactivity. Two different oxidation routes,steam-oxidation and steam-air-stepwise-oxidation, were applied to investigate the recovery behaviors of the lattice oxygen in the oxygen carrier. The characterizations of the oxide were determined by X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), hydrogen temperature-programmed reduction(H_2-TPR) and scanning electron microscopy(SEM). The fresh sample LSFCO exhibits a monocrystalline perovskite structure with cubic symmetry and high crystallinity, except for a little impurity phase due to the antisite defect of Fe/Co disorder. The deconvolution distribution of XPS patterns indicated that Co,and Fe are predominantly in an oxidized state(Fe^(3+) and Fe^(2+)) and(Co^(2+) and Co^(3+)), while O 1s exists at three species of lattice oxygen, chemisorbed oxygen and physical adsorbed oxygen. The double perovskite structure and chemical composition recover to the original state after the steam and air oxidation, while the Co ion cannot incorporate into the double perovskite structure and thus form the CoO just via individual steam oxidation. In comparison to the two different oxidation routes, the sample obtained by steam-oxidation exhibits even higher CH_4 conversion, CO and H_2 selectivity and stronger hydrogen generation capacity. | Kun Zhao Yang Shen Zhen Huang Fang He Guoqiang Wei Anqing Zheng Haibin Li Zengli Zhao | 2017 | Journal of Energy Chemistry2017，26，3： | 3 |
| 4 | Effect of torrefaction on structure and fast pyrolysis behavior of corncobs显示文摘 | Anqing Zheng Zengli Zhao Sheng Chang Zhen Huang Xiaobo Wang Fang He Haibin Li | 2013 | Bioresource Technology2013，，： | 1 |
| 5 | Com-parative analysis of morphological characteristics and effec-tive composition content of wild and cultivated Epimedium pubescens and Epimedium wushanense (Berberidaceae)显示文摘 | QUAN Qiumei FANG Zengli LI Yunxiang | | 0，，29： | 1 |
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