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| 1 | Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma显示文摘BACKGROUND: Notch signaling is critical to physiologic angiogenesis and has been implicated in tumor angiogenesis and metastasis. Notch signaling was reported to exert either oncogenic or tumor-suppressive function in hepatocellular carcinoma (HCC) tumorigenesis. However, the prognostic significance of Notch receptors in HCC remains uncertain. In this study, we investigated the roles of Notch receptors in the prognosis of HCC. METHODS: We investigated the expressions of Notch receptors in tumor tissue microarrays of 288 patients with primary HCC who had undergone curative resection using immunohistochemistry. Additionally, prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 97.1 months. Tumor recurrence was detected in 189 patients (65.6%), and 99 (34.4%) died of HCC. RESULTS: Cytoplasmic expression of Notch1, cytoplasmic expression of Notch3, coexistent nuclear expression of Notch3, and cytoplasmic Notch4 overexpression were observed in 145 (50.3%), 60 (20.8%), 17 (5.9%), and 172 (59.7%) of the 288 HCCs, respectively. Multivariate analyses revealed that Notch1 expression (P=0.029), Edmondson grade Ⅲ (P=0.038), and higher BCLC stage (P<0.001) were independent predictors of shorter disease-free survival. Cytoplasmic Notch3 expression tended to be an independent predictor of shorter disease-free survival (P=0.055). Notch1 expression (P=0.039), Notch4 overexpression (P=0.012), and higher BCLC stage (P<0.001) were independent predictors of shorter disease-specific survival. On univariate analysis, Notch1 expression tended to show an unfavorable influence on disease-specific survival (P=0.063) and Notch4 overexpression did not show an unfavorable influence on disease-specific survival (P=0.103). CONCLUSIONS: Notch1 expression might be an independent predictor of both shorter disease-free survival and shorter disease-specific survival in HCC patients after curative resection. Notch4 overexpression might be an independent predictor of shorter disease-specific survival. Notch1 could be used as an immunohistochemical biomarker to detect patients with a high-risk of recurrence. Notch1 and Notch4 could be used as immunohistochemical biomarkers to detect patients with a shorter disease-specific survival. | Soomin Ahn Jiyeon Hyeon Cheol-Keun Park | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 12 |
| 2 | Cross-regulation between protein L-isoaspartyl O-methyltransferase and ERK in epithelial mesenchymal transition of MDA-MB-231 cells显示文摘目的: 蛋白质 L-isoaspartyl O-methyltransferase (PIMT ) 通过 integrin α 的激活在各种各样的癌症房间线调整房间粘附; v 和 PI3K 小径。上皮的间充质的转变(EMT ) 使上皮的房间能获得间充质的房间的特征,并且允许他们为转移移居。这里,我们与依附或分开的 MDA-MB 231 房间检验了在 PIMT 和 EMT 之间的关系。 | Jiyeon RYU Jihyeok SONG Jieun HEO Yongwoo JUNG Sang-Jin LEE Sungyoul HONG Jae Youl CHO | 2011 | Acta Pharmacologica Sinica2011，32，9： | 5 |
| 3 | Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors显示文摘In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint (DU 20). Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor. | Min-Wook Kim You Chul Chung Hee Chan Jung Moon-Seo Park Young-Min Han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung Minky Kim Manho Kim | 2011 | Neural Regeneration Research2011，6，36： | 4 |
| 4 | Prediction of effluent concentration in a wastewater treatment plant using machine learning models显示文摘Of growing amount of food waste, the integrated food waste and waste water treatment was regarded as one of the efficient modeling method. However, the load of food waste to the conventional waste treatment process might lead to the high concentration of total nitrogen(T-N) impact on the effluent water quality. The objective of this study is to establish two machine learning models—artificial neural networks(ANNs) and support vector machines(SVMs), in order to predict 1-day interval T-N concentration of effluent from a wastewater treatment plant in Ulsan, Korea. Daily water quality data and meteorological data were used and the performance of both models was evaluated in terms of the coefficient of determination(R^2), Nash–Sutcliff efficiency(NSE), relative efficiency criteria(d rel). Additionally, Latin-Hypercube one-factor-at-a-time(LH-OAT) and a pattern search algorithm were applied to sensitivity analysis and model parameter optimization, respectively. Results showed that both models could be effectively applied to the 1-day interval prediction of T-N concentration of effluent. SVM model showed a higher prediction accuracy in the training stage and similar result in the validation stage.However, the sensitivity analysis demonstrated that the ANN model was a superior model for 1-day interval T-N concentration prediction in terms of the cause-and-effect relationship between T-N concentration and modeling input values to integrated food waste and waste water treatment. This study suggested the efficient and robust nonlinear time-series modeling method for an early prediction of the water quality of integrated food waste and waste water treatment process. | Hong Guo Kwanho Jeong Jiyeon Lim Jeongwon Jo Young Mo Kim Jong-pyo Park Joon Ha Kim Kyung Hwa Cho | 2015 | Journal of Environmental Sciences2015，27，6： | 4 |
| 5 | Endoscopic submucosal dissection for early gastric cancer with undifferentiated histology: could we extend the criteria beyond?显示文摘 | Yi Young Kim Seong Woo Jeon JiYeon Kim Jung Chul Park Kwang Bum Cho Kyung Sik Park EunSoo Kim Yun Jin Chung Joong Goo Kwon Jin Tae Jung Eun Young Kim Kyeong Ok Kim ByungIk Jang Si Hyung Lee Chang Hun Yang | 2013 | Surgical Endoscopy2013，，12： | 3 |
| 6 | Automatic Discontinuity Classification of Wind-turbine Blades Using A-scan-based Convolutional Neural Network显示文摘Recent development trends in wind power generation have increased the importance of the safe operation of wind-turbine blades(WTBs). To realize this objective, it is essential to inspect WTBs for any defects before they are placed into operation. However, conventional methods of fault inspection in WTBs can be rather difficult to implement, since complex curvatures that characterize the WTB structures must ensure accurate and reliable inspection. Moreover, it is considered useful if inspection results can be objectively and consistently classified and analyzed by an automated system and not by the subjective judgment of an inspector. To address this concern,the construction of a pressure-and shape-adaptive phased-array ultrasonic testing platform, which is controlled by a nanoengine operation system to inspect WTBs for internal defects, has been presented in this paper. An automatic classifier has been designed to detect discontinuities in WTBs by using an A-scanimaging-based convolutional neural network(CNN). The proposed CNN classifier design demonstrates a classification accuracy of nearly 99%. Results of the study demonstrate that the proposed CNN classifier is capable of automatically classifying the discontinuities of WTB with high accuracy, all of which could be considered as defect candidates. | Jiyeon Choung Sun Lim Seung Hwan Lim Su Chung Chi Mun Ho Nam | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 2 |
| 7 | In vitro differentiation of human adipose tissue-derived stem cells into cells with pancreatic phenotype by regenerating pancreas extract显示文摘 | Jiyeon Lee Duck-Jong Han Song-Cheol Kim | 2008 | Biochemical and Biophysical Research Communications2008，，4： | 2 |
| 8 | A simple, flexible and high-throughput cloning system for plant genome editing via CRISPR-Cas system显示文摘CRISPR-Cas9 system is now widely used to edit a target genome in animals and plants. Cas9 protein derived from Streptococcus pyogenes(Sp Cas9) cleaves double-stranded DNA targeted by a chimeric single-guide RNA(sg RNA). For plant genome editing, Agrobacterium-mediated T-DNA transformation has been broadly used to express Cas9 proteins and sg RNAs under the control of Ca MV 35 S and U6/U3 promoter, respectively. We here developed a simple and high-throughput binary vector system to clone a 19 20 bp of sg RNA, which binds to the reverse complement of a target locus, in a large T-DNA binary vector containing an Sp Cas9 expressing cassette. Twostep cloning procedures:(1) annealing two target-specific oligonucleotides with overhangs specific to the Aar I restriction enzyme site of the binary vector; and(2) ligating the annealed oligonucleotides into the two Aar I sites of the vector, facilitate the high-throughput production of the positive clones. In addition, Cas9-coding sequence and U6/U3 promoter can be easily exchanged via the GatewayTMsystem and unique Eco RI/Xho I sites on the vector, respectively. We examined the mutation ratio and patterns when we transformed these constructs into Arabidopsis thaliana and a wild tobacco, Nicotiana attenuata. Our vector system will be useful to generate targeted large-scale knock-out lines of model as well as non-model plant. | Hyeran Kim Sang-Tae Kim Jahee Ryu Min Kyung Choi Jiyeon Kweon Beum-Chang Kang Hyo-Min Ahn Suji Bae Jungeun Kim Jin-Soo Kim Sang-Gyu Kim | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 9 | Nitrogen mass balance in a constructed wetland treating piggery wastewater effluent显示文摘The nitrogen changes and the nitrogen mass balance in a free water surface flow constructed wetland(CW) using the four-year monitoring data from 2008 to 2012 were estimated. The CW was composed of six cells in series that include the first settling basin(Cell 1), aeration pond(Cell 2), deep marsh(Cell 3), shallow marsh(Cell 4), deep marsh(Cell 5) and final settling basin(Cell 6). Analysis revealed that the NH+4-N concentration decreased because of ammonification which was then followed by nitrification. The NO-3-N and NO-2-N were also further reduced by means of microbial activities and plant uptake during photosynthesis. The average nitrogen concentration at the influent was 37,819kg/year and approximately 45% of that amount exited the CW in the effluent. The denitrification amounted to 34% of the net nitrogen input, whereas the accretion of sediment was only 7%. The biomass uptake of plants was able to retain only 1% of total nitrogen load. In order to improve the nutrient removal by plant uptake, plant coverage in four cells(i.e., Cells 1, 3, 4 and 5) could be increased. | Soyoung Lee Marla C.Maniquiz-Redillas Jiyeon Choi Lee-Hyung Kim | 2014 | Journal of Environmental Sciences2014，26，6： | 2 |
| 10 | Rheological,textural,and functional characteristics of 3D-printed cheesecake containing guava leaf,green tea,and barley sprout powders显示文摘The use of 3D food printing as an alternative to manufacturing customized food is gaining popularity.In this study,functional powders of guava leaf (GL),green tea (GT),and barley sprouts (BS) were tested as edible ink ingredients for printing cheesecake,and their physicochemical and functional properties were evaluated.Particle size and water and oil holding capacities were highest in GL powder,whereas the water-soluble index was highest in BS.In functional powder-added cheesecake,pseudoplastic and shear-thinning behavior was observed which is ideal for 3D printing.The shear modulus (1.87 kPa) of the control cheesecake (without functional powder) was significantly increased to 5 kPa or higher by adding functional powder.The in vitro glycemic index was lowest in GL cheesecake,whereas antioxidant activity and polyphenol content were highest in GT cheesecake.GL and GT powders would be beneficial as an edible ink to improve functional properties,such as antioxidant activity for GT and blood-glucose-lowering effect for BS,with enhanced printability and textural stability of 3D printed cheesecake. | Ye-Eun Park Jeong Kim Hyun Woo Kim Jiyeon Chun | 2022 | Food Bioscience2022，47，3： | 2 |
| 11 | Genotypes of TNF-α , VEGF , hOGG1 , GSTM1 , and GSTT1 : Useful determinants for clinical outcome of bladder cancer显示文摘 | Eun-Jung Kim Pildu Jeong Changyi Quan Jiyeon Kim Suk-Chul Bae Seok Jung Yoon Jong-Won Kang Sang-Cheol Lee Jae Jun Wee Wun-Jae Kim | 2005 | Urology2005，，1： | 1 |
| 12 | 4显示文摘 | Jiyeon Chun Jong Sang Kim Jeong Hwan Kim Enrichment of isoflavone aglycones in soymilk by fermentation with single and mixed cultures of streptococcus infantarius 12 and weissella sp | 2008 | Food Chemistry2008，，109： | 1 |
| 13 | Protein recovery from excess sludge for its use as animal feed显示文摘 | Jiyeon Hwang Lei Zhang Sunkeun Seo Yong-Woo Lee Deokjin Jahng | 2008 | Bioresource Technology2008，，18： | 1 |
| 14 | Expression of IL-10,TGF-Pi and TNF-a in CulturedKeratinocytes (HaCaT Cells) afterIPL Treatment or ALA-IPL Photodynamic Treatmen显示文摘 | JiYeon Byun Hae Young Choi Ki Bum Myung | 2009 | Ann Dermatol(Seoul)2009，21，1： | 1 |
| 15 | High photocatalytic hydrogen production over the band gap-tuned urchin-like Bi 2 S 3 -loaded TiO 2 composites system显示文摘 | Jiyeon Kim Misook Kang | 2012 | International Journal of Hydrogen Energy2012，，10： | 1 |
| 16 | Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95显示文摘Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast maturation.Here, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone mass.Using in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex. | Hyunsoo Kim Noriko Takegahara Matthew CWalsh Sarah AMiddleton Jiyeon Yu Jumpei Shirakawa Jun Ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong Kim Yongwon Choi | 2020 | Bone Research2020，8，1： | 1 |
| 17 | Glutathione S-transferase as a biomarker in the Antarctic bivalve Laternula elliptica after exposure to the polychlorinated biphenyl mixture Aroclor 1254显示文摘 | Hyun Park In-Young Ahn Hakjun Kim Jiyeon Lee Seung Chul Shin | 2009 | Comparative Biochemistry and Physiology Part C2009，，4： | 1 |
| 18 | Biodegradation of coumaphos, chlorferon, and diethylthiophosphate using bacteria immobilized in Caalginate gel beads 显示文摘 | Jiyeon H Cady R E James R W | 2009 | Bioresource Technology2009，100，3： | 1 |
| 19 | Reduction of Perceived Social Distance as an Explanation for Media’s Influence on Personal Risk Perceptions: A Test of the Risk Convergence Model显示文摘 | Jiyeon So Robin Nabi | 2013 | Hum Commun Res2013，，3： | 1 |
| 20 | Biodegradation of coumaphos, chlorferon, and diethylthiophosphate using bacteria immobilized in Caalginate gel beads 显示文摘 | Jiyeon H Cady R E James R W | 2009 | BioresourceTechnology2009，100，3： | 1 |
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