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| 1 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 2 | Overcoming Jahn-Teller distortion for spinel Mn phase显示文摘 | Sun Y K Jeon Y S Lee H J | 2000 | Electrochem SolidState Lett2000，3，： | 2 |
| 3 | A UML-based Test Model for Component Integration Test显示文摘 | Choi B J Yoon H J Jeon J O | 1999 | Workshop on Software Atchitecture and Component1999，，12： | 1 |
| 4 | Hydrogen-reduction behavior and microstructural characteristics of WO3-CuO powder mixtures with various milling time显示文摘 | Oh S T Jeon H | 2003 | Journal of Alloys and Compounds2003，，354： | 1 |
| 5 | Abstracting Access Patterns of Dynamic Memory Using Regular Expressions 显示文摘 | Jeon J Shin K Han H | 2008 | ACM Transactions on Architecture and Code Optimization2008，5，4： | 1 |
| 6 | Novel molecular drug carrier:Encapsulation of oxaliplatin in cucurbit uril and its effects on stability and reactivity of the drug显示文摘 | JEON Y J KIM S Y KO Y H | 2005 | Org Biomol Chem2005，3，11： | 1 |
| 7 | 显示文摘 | Choi M H Jeon B H Chung I J | 2000 | Polymer2000，41，： | 1 |
| 8 | Application of the surface complexation model to heavy metal sorption equilibria onto aminated chitosan显示文摘 | CHOONG JEON WOLFGANG H HOLL | 2004 | Hydrometallurgy2004，71，34： | 1 |
| 9 | Strength and deformation of steel fibre reinforced concrete at very low temperature显示文摘 | Jeon S J Chung C H | 1981 | International Journal of Cement Composites and Light weight Concrete1981，2，： | 1 |
| 10 | Polysomnographic effects of nasal surgery for snoring and obstructive sleep apnea 显示文摘 | Kim S T Choi J H Jeon H J | 2004 | Acta Otolaryngol2004，124，2： | 1 |
| 11 | Phospholipase D2 induces stressfiber formation through mediating nucleotide exchange for RhoA显示文摘 | Jeon H Kwak D Noh J | 2011 | Cell Signal2011，23，8： | 1 |
| 12 | 显示文摘 | Jeon H Kim D J Kim S J | 2013 | Fuel Processing Tech nology2013，116，： | 1 |
| 13 | Effect of nitrate on the degradation of bisphenol A by UV/H202 and ozone/H2 02 oxi- dation in aqueous solution 显示文摘 | Park C G Choi E S Jeon H W | 2014 | Desalination and Water Treat- ment2014，52，46： | 1 |
| 14 | Reduction of toxicity of antimicrobial compounds by degradation processes using activated sludge, gamma radiation, and UV显示文摘 | Kim H Y Jeon J Yu S | 2013 | Chemosphere2013，93，10： | 1 |
| 15 | Investigation on removal of hardness ions by capacitive deionization (CDI)for water softening applications 显示文摘 | Seo S J Jeon H Lee J K | 2010 | Water Research2010，44，7： | 1 |
| 16 | Limonoid derivatives and itspesticidal activities显示文摘 | PARK E S BAE I K JEON H J | 2014 | Entomological Research2014，44，4： | 1 |
| 17 | Optimum spacing of TBM disc cutters: a numerical simulation using the three-dimensional dynamic fracturing method 显示文摘 | CHO J W JEON S YU S H | 2010 | Tunnelling and Underground Space Technology2010，25，3： | 1 |
| 18 | Detection and titer estimation of eseherlehia eoli using aptamer-funetionalized single-walled carbon-nanotube field-effect transistors显示文摘 | SO H M PARK D W JEON E K | 2008 | Small2008，4，2： | 1 |
| 19 | Clinicopathologie features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer显示文摘 | Jeon Y K Chung J H Park W S | 2006 | Lung Cancer2006，54，3： | 1 |
| 20 | The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells(hMSCs)and in-duce chondrogenesis显示文摘 | Kim J H Park J S Yang H N Woo D G Jeon S Y Do H J | 2011 | Biomaterials2011，32，： | 1 |
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