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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 3 | Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer显示文摘 | Kim J H Choi E K Kim S B | 2001 | Int J Radiat Oncol Biol Phys2001，50，1： | 2 |
| 4 | Polymer-polymer miscibility study for plastic gradient index optical fiber 显示文摘 | LEE B CHOI W Y WALKER J K | 2000 | Polym Eng Sci2000，40，9： | 1 |
| 5 | Serotonin receptor 2A gene polymorphism ( - 1438A/G) and short - term treatment response to citalopram 显示文摘 | Choi M J Kang RH Ham B J | 2005 | Neuropsychobiology2005，52，3： | 1 |
| 6 | 显示文摘 | Choi W B Chung D S Kang J H | 1999 | Applied Physics Letters1999，75，20： | 1 |
| 7 | A UML-based Test Model for Component Integration Test显示文摘 | Choi B J Yoon H J Jeon J O | 1999 | Workshop on Software Atchitecture and Component1999，，12： | 1 |
| 8 | Growth characteristics of carbon nanotubes via aluminum nanopore template on Si substrate using PECVD显示文摘 | Kim M J Choi J H Park J B | 2003 | ThinSolid Films2003，435，： | 1 |
| 9 | Cholangioearcinoma:pictorial essay of CT and cholangiographic findings显示文摘 | Han J K Choi B I Kim A Y | 2002 | Radiographics2002，22，1： | 1 |
| 10 | A new distributed location management algorithm for broadband personal communication networks显示文摘 | KIN B C CHOI J S UN C K | 1995 | IEEE Transactions on Vehicular Technology1995，44，3： | 1 |
| 11 | The effect of coupling agent on electrical and mechanical properties of carbon fiber/phenolic resin composites 显示文摘 | Choi M H J eon B H Chung I J | 2000 | Polymer2000，41，9： | 1 |
| 12 | 显示文摘 | Choi M H Jeon B H Chung I J | 2000 | Polymer2000，41，： | 1 |
| 13 | Compound surface modeling and machining显示文摘 | CHOI B K LEE C S HWANG J S | 1988 | Computer-Aided Design1988，20，3： | 1 |
| 14 | Effect of monensin fish oil or their combination on in vitro fermentation and conjugated linoleic acid (CLA) production by ruminal bacteria显示文摘 | WANG J H ZHU B W CHOI Y J | 2005 | Animal Feed Science and Technology2005，120，34： | 1 |
| 15 | Nosocomial fungal infections: epidemiology, diagnosis, and treatment 显示文摘 | Perlroth J Choi B Speltberg B | 2007 | Med Mycoi2007，45，4： | 1 |
| 16 | Preparation of Ru thin film layer on Si and TaN/Si as diffusion barrier by plasma enhanced atomic layer deposition 显示文摘 | Choi B H Lim Y H Lee J H0 | 2010 | Microelec- tronie Engineering2010，87，： | 1 |
| 17 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
| 18 | Novel Leuconostoc citreum starter culture system for the fermentation of kimchi,a fermented cabbage product显示文摘 | Choi I K Jung S H Kim B J | 2003 | Antonie Van Leeuwenhoek2003，84，4： | 1 |
| 19 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 20 | A new design of polarcap differential codebook for temporally/spatially correlated MISO channels显示文摘 | Choi J Clerckx B Namyoon L | | 0，，02： | 1 |
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