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| 1 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 2 | 3D Photo-Fabrication for Tissue Engineering and Drug Delivery显示文摘The most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix(ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photofabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics. | Rúben F.Pereira Paulo J.Bártolo | 2015 | Engineering2015，1，1： | 6 |
| 3 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 4 | Benefits of the use of blood conservation in scoliosis surgery显示文摘AIM To investigate whether autologous blood transfusion(ABT) drains and intra-operative cell salvage reduced donor blood transfusion requirements during scoliosis surgery.METHODS Retrospective data collection on transfusion requirements of patients undergoing scoliosis surgery is between January 2006 and March 2010. There were three distinct phases of transfusion practice over this time: Group A received 'traditional treatment' with allogeneic red cell transfusion(ARCT) in response to an intra- or postoperative anaemia(Hb < 8 g/d L or a symptomatic anaemia); Group B received intra-operative cell salvage in addition to 'traditional treatment'. In group C,ABT wound drains were used together with both intra-operative cell salvage and 'traditional treatment'.RESULTS Data from 97 procedures on 77 patients,there was no difference in mean preoperative haemoglobin levels between the groups(A: 13.1 g/d L; B: 13.49 g/d L; C: 13.66 g/d L). Allogeneic red cell transfusion was required for 22 of the 37 procedures(59%) in group A,17 of 30(57%) in group B and 16 of 30(53%) in group C. There was an overall 6% reduction in the proportion of patients requiring an ARCT between groups A and C but this was not statistically significant(χ2 = 0.398). Patientsin group C received fewer units(mean 2.19) than group B(mean 2.94)(P = 0.984) and significantly fewer than those in group A(mean 3.82)(P = 0.0322). Mean length of inpatient stay was lower in group C(8.65 d) than in groups B(12.83) or A(12.62).CONCLUSION When used alongside measures to minimise blood loss during surgery,ABT drains and intra-operative cell salvage leads to a reduced need for donor blood transfusion in patients undergoing scoliosis surgery. | Peter R Loughenbury Lyeanda Berry Ben T Brooke Abhay S Rao Robert A Dunsmuir Peter A Millner | 2016 | World Journal of Orthopedics2016，7，12： | 3 |
| 5 | Incidence and cost of accidents among attention - deficit/hyperactivity disorder patients 显示文摘 | Swensen A Bimbanm HG Ben Hamadi R | 2004 | Adolese Health2004，35，4： | 1 |
| 6 | Long-range order in nonporous hybrid organic-inorganic silicon-based materials by sol-gel processing 显示文摘 | Ben F Boury B Corriu R J P | 2002 | Adv Mater2002，14，15： | 1 |
| 7 | Functional and safety aspects of enterococei isolated from different Spanish foods显示文摘 | Ben Omar N Castro A Lueas R | 2004 | Syst Appl Microbiol2004，27，1： | 1 |
| 8 | Contributions fromglacially derived sediment to the global iron(oxyhydroxide)cy-cle:Implications for iron delivery to the oceans显示文摘 | Raiswell R Tranter M Benning L G | 2006 | Geochimicaet Cosmochimica Acta2006，70，11： | 1 |
| 9 | TNFalpha in the development of insulin resistance and other disorders in metabolic syndrome显示文摘 | Gwozdziewiczova S Lichnoska R Ben Yahia R | 2005 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2005，149，1： | 1 |
| 10 | Technology foresight: a review of recent government Exercise 显示文摘 | BEN R M | 1996 | Science Technology Industry Review1996，1996，17： | 1 |
| 11 | A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa 显示文摘 | Petronius D Bergman R Ben Izhak O | 2003 | Am J Dermatopathol2003，25，3： | 1 |
| 12 | Three-dimensional structure of myosin subfragment-1 : a molecular motor显示文摘 | Rayment I Rypniewski WR Schmidt-Base K Smith R Tomchik DR Benning MM Winkelmann DA Wesenberg G Holden HM | 1993 | Science1993，261，： | 1 |
| 13 | Estimation of uncertainties in ICP-MS analysis:a practical methodology显示文摘 | Barwick Vicki J Stephen L R Ellison Ben Fairman | 1999 | Analytica Chimica Acta1999，，394： | 1 |
| 14 | Non-Pt catalyst as oxygen reduction reaction in microbial fuel cells: A review显示文摘 | Ben Liew K Daud W R W Ghasemi M | 2014 | International Journal of Hydrogen Energy2014，39，10： | 1 |
| 15 | Value of rou- tine bone scans in patients with bone sarcomas before local treatment显示文摘 | Bakri D Bar-Shalona R Ben Arush MW | 2011 | J Pediatr Hematol Oneol2011，33，2： | 1 |
| 16 | Expression of ACC oxi- dase antisense gene inhibits ripening of cantaloupe melon fruits显示文摘 | Ayub R Guis M Ben Amor M | 1996 | Nature Biotechnology1996，14，： | 1 |
| 17 | Effect of temperature on the performance of an anaerobic tubular reactor treating fruit and vegetable waste 显示文摘 | Bouallagui H Haouari O Touhami Y Ben Cheikh R Marouani L Hamdi M | 2004 | Process Biochemistry2004，39，12： | 1 |
| 18 | Isolation and identifica- tion of mycoparasitic isolates of Tdchoderma aspere/um with potential for suppression of black pod disease of cacao in Cameroon显示文摘 | Tondje P R Roberts D P Ben M C | 2007 | Bio- logical Control2007，43，2： | 1 |
| 19 | Secondary Forests as Tem- porary Carbon Sinks?The Economic Impact of Accounting Methods on Reforestation Projects in the Tropics显示文摘 | OLSCHEWSKI R BEN~TEZ P C | 2005 | Ecolog- ical Economics2005，55，3： | 1 |
| 20 | Level of glycemic control and pregnancy outcome in type 1 diabetes: A comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions显示文摘 | Chen R Ben H A Weismann B A | 2007 | Am J Obstet Gynecol2007，197，4： | 1 |
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