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| 1 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | Split-dose menthol-enhanced PEG vs PEG-ascorbic acid for colonoscopy preparation显示文摘AIM:To compare the efficacy and palatability of 4L polyethylene glycol electrolyte(PEG)plus sugar-free menthol candy(PEG+M)vs reduced-volume 2 L ascorbic acid-supplemented PEG(Asc PEG).METHODS:In a randomized controlled trial setting,ambulatory patients scheduled for elective colonoscopy were prospectively enrolled.Patients were randomized to receive either PEG+M or Asc PEG,both splitdosed with minimal dietary restriction.Palatability was assessed on a linear scale of 1 to 5(1=disgusting;5=tasty).Quality of preparation was scored by assignment-blinded endoscopists using the modified Aronchick and Ottawa scales.The main outcomes were the palatability and efficacy of the preparation.Secondary outcomes included patient willingness to retake the same preparation again in the future and completion of the prescribed preparation.RESULTS:Overall,200 patients were enrolled(100patients per arm).PEG+M was more palatable than Asc PEG(76%vs 62%,P=0.03).Completing the preparation was not different between study groups(91%PEG+M vs 86%Asc PEG,P=0.38)but more patients were willing to retake PEG+M(54%vs 40%respectively,P=0.047).There was no significant difference between PEG+M vs Asc PEG in adequate cleansing on both the modified Aronchick(82%vs77%,P=0.31)and the Ottawa scale(85%vs 74%,P=0.054).However,PEG+M was superior in the left colon on the Ottawa subsegmental score(score0-2:94%for PEG+M vs 81%for Asc PEG,P=0.005)and received significantly more excellent ratings than Asc PEG on the modified Aronchick scale(61%vs 43%,P=0.009).Both preparations performed less well in afternoon vs morning examinations(inadequate:29%vs 15.2%,P=0.02).CONCLUSION:4 L PEG plus menthol has better palatability and acceptability than 2 L ascorbic acidPEG and is associated with a higher rate of excellentpreparations;Clinicaltrial.gov identifier:NCT01788709. | Ala I Sharara Ali H Harb Fayez S Sarkis Jean M Chalhoub Rami Badreddine Fadi H Mourad Mahmoud Othman Omar Masri | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 4 | Toll receptors in innate immunity显示文摘 | Jean L I Jules H A | 2001 | Trends in Cell Biology2001，11，7： | 1 |
| 5 | Radar rainfall estimation for the identification of debris-flow occurrence thresholds 显示文摘 | Marra Francesco Nikolopoulos Efthymos I Creutin Jean Dominique Borga Marco | 2014 | Journal of Hydrology2014，519，： | 1 |
| 6 | Selective decrease in axonal nerve growth factor and insulin-like growth factor I immunoreactivity in axonopathies of unknown etiology 显示文摘 | Fressinaud C Jean I Dubas F | 2003 | Acta Neuropathol (Berl)2003，105，： | 1 |
| 7 | Service-learning research显示文摘 | Jean I | 2011 | Demystifying Res2011，37，2： | 1 |
| 8 | Clinical presentation and imaging of bone and soft-tissue sarcomas显示文摘 | Hakan I Jean S William N | 2010 | Cleveland Clinic Journal Of Medicine2010，77，1： | 1 |
| 9 | Vehicle dispatching with timedependent travel times显示文摘 | Soumia I Michel G Jean Y | 2003 | European Journal of Operational Research2003，144，2： | 1 |
| 10 | The association between IGF-Ⅰ and bone mineraldensity in women and men: the Framingham heart study显示文摘 | Jean I A Clifford J R Visser M | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 11 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet2012，，9829： | 1 |
| 12 | Regional distribution of acoustic based lung vibration as a function of mechanical ventilation mode 显示文摘 | Dellinger RP Jean S Cinel I | 2007 | Crit Care2007，11，： | 1 |
| 13 | Regional distribution of acousticbased lung vibration as a function of mechanical ventilation mode显示文摘 | Dellinger RP Jean S Cinel I | 2007 | Critical Care2007，11，1： | 1 |
| 14 | Vaginal intraepi- thelial neoplasia (VAIN) after radiation therapy for gyneco- logic malignancies: a clinically recalcitrant entity显示文摘 | Liao JB Jean S Wilkinson-Ryan I | 2011 | Gynecol Oncol2011，120，1： | 1 |
| 15 | Ion homeostasis in brain cells : Differences in intracellular ion responses to energy limitation between cultured neurons and glial cells显示文摘 | Silver I A Jeans J Erecinska M | 1997 | Neuroscience1997，78，： | 1 |
| 16 | Vaginal intraepithelial neo- plasia (VAIN) after radiation therapy for gynecologic malignaneies:a clinically recalcitrant entity 显示文摘 | Liao JB Jean S Wilkinson-Ryan I | 2011 | Gynecologic oncology2011，120，1： | 1 |
| 17 | The binding of organic ions by proteim:effect of temperature显示文摘 | Klotz I M Jean M | 1949 | J Am Chem Soc1949，71，3： | 1 |
| 18 | Regionald istribution of acoustic based lung vibration as afunction of mechanical ventilation mode 显示文摘 | Dellinger RP Jean S Cinel I | 2007 | Crit Care2007，11，1： | 1 |
| 19 | Neurotrophin-3 specifically increases mature oligodendrocyte population and enhances remyelination after chemical demyelination of adult rat CNS显示文摘 | Jean I Lavialle C Barthelaix-Pouplard A | 2003 | Brain Res2003，972，12： | 1 |
| 20 | REM and NREM power spectralanalysis on two consecutive nights inpsychophysiological and paradoxicalinsomnia sufferers 显示文摘 | St - Jean G Turcotte I P^russe AD | 2013 | Int JPsychophysiol2013，89，2： | 1 |
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