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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | Teach the teachers: an observational study on mentor traineeship in gynecological laparoscopic surgery显示文摘 | Kolkman W Engels LE Smeets MJ Jansen FW | 2007 | Gynecol Obstet Invest2007，64，1： | 1 |
| 4 | Application of the no action level(NAL) protocol to correct for prostate motion based on electronic portal imaging of implanted markers显示文摘 | de Boer HC van Os MJ Jansen PP | | 0，，： | 1 |
| 5 | Loss of network efficiency associated with cognitive decline in chronic epilepsy显示文摘 | Vlooswijk MC Vaessen MJ Jansen JF | | 0，，： | 1 |
| 6 | Inflammatory cytokines in an experimental model for the multiple organ dysfunction syndrome 显示文摘 | Jansen MJ Hendriks T Vogels MT | 1996 | Crit Care Med1996，24，： | 1 |
| 7 | Amonoclonyal antibody a- gainst tumur necrosis factor - alpha improvs survival in experimental multiple organ dysfunction syndrome 显示文摘 | Jansen MJ Hendriks T Hermsen R | 1998 | Cytokine1998，10，： | 1 |
| 8 | Overexpression of the HER2 oncogene does not play a role in high - grade osteosarcomas 显示文摘 | Anninga JK van de Vijver MJ Cleton - Jansen AM | 2004 | Eur J Cancer2004，40，7： | 1 |
| 9 | Preliminary re- suits of a longkudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxoru- bicin and cyelophosphamide显示文摘 | Jansen CE Dodd MJ Miaskowski CA | 2008 | Psychooncology2008，17，12： | 1 |
| 10 | The effect of a change in ambient temperature on blood pressure in normotensives 显示文摘 | Jansen PM Leineweber MJ Thien T | 2001 | J Hum Hypertens2001，15，： | 1 |
| 11 | Cognitive and behavioural findings in children with fronta lobe epilepsy 显示文摘 | Brlaakman HM Vaessen MJ Jansen JF | 2012 | Eur J Paediatr Neurol2012，16，6： | 1 |
| 12 | The effect of a change in ambi- ent temperature on blood pressure in normotensive 显示文摘 | Jansen PM Leineweber MJ Thien T | 2001 | J Hum Hyper- tens2001，15，： | 1 |
| 13 | A prospective longitu- dinal study of chemotherapy-induced cognitive changes in breast cancer patients 显示文摘 | Jansen CE Cooper BA Dodd MJ | 2011 | Support Care Cancer2011，19，10： | 1 |
| 14 | Interleukin-10 mitigates the development of the zymosan-induced multiple organ dysfunction syndrome in mice显示文摘 | Jansen MJ Hendriks Th De Man B | | Cytokine 9990，11，9： | 1 |
| 15 | Interleukin - 10 miti-gates the development of the zymosan - induced multiple organdysfunction syndrome in mice显示文摘 | Jansen MJ Hendriks Th De Man B al | 1999 | Cytokine1999，11，9： | 1 |
| 16 | Loss of network efficiency associated with cognitive decline in chronic epilepsy 显示文摘 | Vlooswijk MCG Vaessen MJ Jansen JFA | 2011 | Neurology2011，77，10： | 1 |
| 17 | Peripheral blood progenitor cell transplantation显示文摘 | Jansen J Thompson JM Dugan MJ | 2002 | Ther Apher Dial2002，6514，： | 1 |
| 18 | Determination of the level of benzo pyrene in fatty foods and food supplements显示文摘 | Van der Wielen JC Jansen JT Martena MJ | 2006 | Food Addit Contain2006，23，7： | 1 |
| 19 | Gradual development of organ damage in the murine zymozan-induced multiple Organ dysfunction syndrome显示文摘 | Jansen MJ Hendriks T Verhofstad AA | 1997 | Shock1997，8，： | 1 |
| 20 | White mat ter network abnormalities are associated with cognitive decline in chronic epilepsy 显示文摘 | Vaessen MJ Jansen JFA Vlooswijk MCG | 2012 | Cerebral Cortex2012，22，9： | 1 |
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