|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Service recovery: a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，4： | 3 |
| 3 | Being Big or Growing Fast;a systematic review of size and growth in infancy and later obesity 显示文摘 | JANIS B DAVID F PATRICIA L | 2005 | Bmj2005，331，7522： | 1 |
| 4 | Intertwin anastomoses in monochorionic placentas after fetoscopic laser coagulation for twinto-twin transfusion syndrome:is there more than meets the eye显示文摘 | Lewi L Jani J Cannie M | | 0，，： | 1 |
| 5 | Service recovery:a framework and empirical investigation显示文摘 | Janis L Miller Christopher W Craighead Kirk R Karwan | 2000 | Journal of Operations Management2000，，18： | 1 |
| 6 | Lipoprotein-cyclodextrin interaction显示文摘 | Sharma A Janis L | 1991 | Clin Chim Acta1991，199，2： | 1 |
| 7 | The Synergism of Exper- tise in Clinical Teaching: An Integrative Model for Nursing Education显示文摘 | Mabel H Andrea B Janie L | 2000 | J Nurs Edu2000，39，6： | 1 |
| 8 | The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort studys显示文摘 | Lewi L Jani J Blickstein I | 2008 | Am J Obstet Gynecol2008，199，5： | 1 |
| 9 | The Efficient Production of 'Reputation' by Prestige Research Universities in the UnitedStates显示文摘 | MCGUIRE J W RICHMAN M L DALY R F JOR- JANI | 1988 | The Journal of Higher Education1988，59，4： | 1 |
| 10 | Influence of mono-acylglycerols on growth inhibition of micromycetes in vitro and on bread显示文摘 | BUNKOV/ L KREJCI J JANIS R | 2010 | Eur J Lipid Sci Technol2010，，112： | 1 |
| 11 | Circulating cell-free fetalmessenger RNA levels after fetoscopic interventions ofcomplicated pregnancies显示文摘 | Tjoa ML Jani J Lewi L | 2006 | Am J Obstet Gynecol2006，195，1： | 1 |
| 12 | Communi- cation and persuasion; psychological studies of opinion change显示文摘 | Hovland C I Janis I L Kelley H H | 1953 | 1953，，： | 1 |
| 13 | Expression of cholera toxin B subunit in transgenic tomato plants 显示文摘 | Jani D Meena L S Rizwan-ul-Haq Q M | 2002 | Transgenic Res2002，11，5： | 1 |
| 14 | Expanding the ecological niche approach: Relationships between variability in niche position and species richness显示文摘 | Janne S Jani H Jyrki L Risto V | 2011 | Ecological Complexity2011，8，1： | 1 |
| 15 | Simple sequence repeat (SSR) markers in the ectomycorrhizal fungus Laccaria bicoior for environmental monitoring of introduced strains and molecular ecology applications显示文摘 | Jany J L Bousquet J Gagne A | 2006 | Mycological Research2006，110，： | 1 |
| 16 | Animal models of Helicobacter pylori infection and disease显示文摘 | Jani L O'Rourke Adrian Lee | 2003 | Microbes and Infection2003，5，： | 1 |
| 17 | One-year outcomes of panretinal photocoagulation in proliferative diabetic retinopathy显示文摘 | Richard S Kaiser Maureen G Maguire Juan E Grunwald Douglas Lieb Binoy Jani Alexander J Brucker Albert M Maguire Allen C Ho Stuart L Fine | 2000 | American Journal of Ophthalmology2000，，2： | 1 |
| 18 | T2 quantifications oflungs in the fetal lamb with experimentally-induced congenitaldiaphragmatic hernia显示文摘 | Breysem L Bosnians H Jani J | 2007 | Fetal Diagn Ther2007，22，： | 1 |
| 19 | The effect of osmo- induced stress on product formation by Zymomonas mobilis 显示文摘 | Martins B Armands V Janis L | 2000 | International journal of food microbiology2000，55，13： | 1 |
| 20 | Placental sharing, birthweight discordance and vascular anastomoses in monochorionic diamni- otic twin placentas 显示文摘 | Lewi L Cannie M Jani J | 2007 | Am J Obstet Gynecol2007，197，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员