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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Inflammation, Telomere Length, and Grip Strength: A 10-year Longitudinal Study显示文摘 | Daniel Baylis Georgia Ntani Mark H. Edwards Holly E. Syddall David B. Bartlett Elaine M. Dennison Carmen Martin-Ruiz Thomas Zglinicki Diana Kuh Janet M. Lord Avan Aihie Sayer Cyrus Cooper | 2014 | Calcified Tissue International2014，，1： | 1 |
| 3 | E-commerce adoption of travel and tourism organizations in South Africa, Kenya,Zimbabwe and Uganda显示文摘 | Tonderai Maswera Ray Dawson Janet Edwards | 2007 | Telematics and Informatics2007，，3： | 1 |
| 4 | Management of Bladder Function after Outpatient Surgery显示文摘 | Janet D. Pavlin Edward G. Pavlin Dermot R. Fitzgibbon Meagan E. Koerschgen Terryn M. Plitt | 1999 | Anesthesiology1999，，1： | 1 |
| 5 | PET/CT Fusion Scan Enhances CT Staging in Patients with Pancreatic Neoplasms显示文摘 | Jeffrey M. Farma MD Alfredo A. Santillan MD MPH Marcovalerio Melis MD Janet Walters RN CCM Daly Belinc RN BSN Dung-Tsa Chen PhD Edward A. Eikman MD Mokenge Malafa MD | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 6 | Quality of Life in Patients With Brain Metastases Using the EORTC QLQ-BN20+2 and QLQ-C15-PAL显示文摘 | Amanda Caissie Janet Nguyen Emily Chen Liying Zhang Arjun Sahgal Mark Clemons Marc Kerba Palmira Foro Arnalot Cyril Danjoux May Tsao Elizabeth Barnes Lori Holden Brita Danielson Edward Chow | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 7 | , Photochemical Reduction of Hexavalent Chromium in Glycerol-Containing Solutions显示文摘 | Edward J Y Janet H Samantha M | 2003 | Environmental Pollution2003，117，： | 1 |
| 8 | PET/CT Fusion Scan Enhances CT Staging in Patients with Pancreatic Neoplasms显示文摘 | Jeffrey M. Farma MD Alfredo A. Santillan MD MPH Marcovalerio Melis MD Janet Walters RN CCM Daly Belinc RN BSN Dung-Tsa Chen PhD Edward A. Eikman MD Mokenge Malafa MD | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 9 | PET/CT Fusion Scan Enhances CT Staging in Patients with Pancreatic Neoplasms显示文摘 | Jeffrey M. Farma Alfredo A. Santillan Marcovalerio Melis Janet Walters Daly Belinc Dung-Tsa Chen Edward A. Eikman Mokenge Malafa | 2008 | Annals of Surgical Oncology2008，，： | 1 |
| 10 | Sunscreen prevention of melanoma in man and mouse显示文摘 | Heather L. P.Klug Janet A.Tooze CariGraff‐Cherry Miriam R.Anver Frances P.Noonan Thomas R.Fears Margaret A.Tucker Edward C.De Fabo GlennMerlino | 2010 | Pigment Cell & Melanoma Research2010，，： | 1 |
| 11 | Cities, regions and the decline of transport costs显示文摘 | Edward L. Glaeser Janet E. Kohlhase | 2003 | Papers in Regional Science2003，，1： | 1 |
| 12 | Endocytic function,glycosaminoglycan specificity,and antibody sensitivity of the recombinant human 190-Kda hyaluronan receptor for endocytosis显示文摘 | Edward NH Janet AW Paul HW | 2004 | J Biol Chem2004，279，36： | 1 |
| 13 | Cities, regions and the decline of transport costs显示文摘 | Edward L. Glaeser Janet E. Kohlhase | 2003 | Papers in Regional Science2003，，1： | 1 |
| 14 | Relationship between extremely low total serum IgE levels and rhinosinusitis显示文摘 | Todd A. Levin Dennis R. Ownby Phillip H. Smith Edward L. Peterson L.K. Williams Janet Ford Penny Young Christine C. Johnson | 2006 | Annals of Allergy, Asthma & Immunology2006，，5： | 1 |
| 15 | Dietary fatty acid intakes and the risk of ovu - latory infertility显示文摘 | Chavarro Jorge E Rich- Edwards Janet W Rosner Bernard A | 2007 | American Journal of Clinical Nutrition2007，85，1： | 1 |
| 16 | Intracerebral Transplantation of Bone Marrow‐Derived Mesenchymal Stem Cells Reduces Amyloid‐Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses显示文摘 | Jong KilLee Hee KyungJin ShogoEndo Edward H.Schuchman Janet E.Carter Jae‐sungBae | 2010 | STEM CELLS2010，，2： | 1 |
| 17 | PPA与出血性中风相关性显示文摘背景:PPA(phenylpropanolamine,苯丙醇胺)常见于食欲抑制药和咳嗽感冒药中,以往病例报告表明含PPA的药物与出血性中风有关,通常发生在首次使用后。为阐明二者相关性,我们设计了一项病例对照研究。方法:18~49岁的男、女性研究病例来自美国43所医院,其合格标准包括在参与项目前30天内发生蛛网膜下腔出血或颅内出血,而既往并无确诊的脑损伤史。采用随机电话拨号,为每个病例安排2例对照进行面访。结果:调查人群包括702名病例和1376名对照。女性服用含PPA食欲抑制药和出血性中风危险之间相关联的调整比值比为16.58(95%可信区间1.51~182.21,P=0.02);女性首次服用含PPA药物与出血性中风危险之间关联的调整比值比3.13(95%可信区间0.86~11.46,P=0.08),所有首次服用的PPA皆为咳嗽感冒药。男、女性调查人群服用含PPA药物与出血性中风危险二者关联的调整比值比为1.49(95%可信区间0.84~2.64.P=0.17);男、女性调查人群服用含PPA的咳嗽感冒药与出血性中风危险二者关联的调整比值比为1.23(95%可信区间0.68~2.24,P=0.49),服用舍PPA的食欲抑制药与出血性中风危险关联的调整比值比为15.92(95%可信区间1.38~184.13,p=0.03)。对男性的分析结果表明:服用含PPA的咳嗽感冒药未引起出血性中风危险增加,男性无一例使用? | Walter N. Kernan Catherine M. Viscoli Lawrence M. Brass Joseph P. Broderick Thomas Brott Edward Feldmann Lewis B. Morgenstern Janet Lee Wilterdink Ralph I. Horwitz 陈关君 | 2001 | 药物不良反应杂志2001，3，1： | 1 |
| 18 | Symptom clusters using the Spitzer quality of life index in patients with brain metastases—a reanalysis comparing different statistical methods显示文摘 | Luluel Khan Gemma Cramarossa Madeline Lemke Janet Nguyen Liying Zhang Emily Chen Edward Chow | 2013 | Supportive Care in Cancer2013，，2： | 1 |
| 19 | Photochemical Reduction of Hexavalent Chromium in Glycerol-Containing Solutions 显示文摘 | Edward J k Janet H Samantha M | 2003 | Environmental Pollution2003，117，： | 1 |
| 20 | Abdominal sacrocolpopexy and urinary incontinence: surgical planning based on urodynamics显示文摘 | Denise M. Elser Michael D. Moen Edward J. Stanford Kristinell Keil Catherine A. Matthews Neeraj Kohli Fleming Mattox Janet Tomezsko | 2010 | American Journal of Obstetrics and Gynecology2010，，4： | 1 |
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