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| 1 | Antidiabetic activity of methanolic bark extract of Alhizia odoratissima Benth.in alloxan induced diabetic albino mice显示文摘Objective:To evaluate the antidiabetic potential of methanolic extract of Albizia odoratissima Benth.bark in alloxan induced diabetic mice.Methods:Group-Ⅰ(normal control) mice received only basal diet without any treatment.In Group-Ⅱ(Diabetic control) mice,diabetes was induced by alloxan(150 mg/kg i.p.) and received only Tween 80.5%v/v in normal saline. Group-Ⅲand Group-Ⅳmice received metformin(10 mg/kg) and gliclazide(10 mg/kg) as standard drugs.Group-ⅤandⅥmice received methanolic bark extract of Albizia odoratissima at doses of 250 and 500 mg/kg body weight p.o.,respectively.Results:The results of the study indicates that Albizia odoratissima bark extract significantly(P<0.01) reduced the blood sugar level.The bark extract also significantly reduced the levels of serum cholesterol,triglycerides, serum glutamic-oxaloacetic transaminase,serum glutamic-pyruvic transaminase,alkaline phosphatase and decreases level of total proteins in alloxan induced diabetic mice.Conclusions: Methanolic extract of Albizia odoratissima has protective effects on the protection of vital tissues(pancreas,kidney,liver,heart and spleen),thereby reducing the causation of diabetes in experimental animals. | Dinesh Kumar Sunil Kumar Sonia Kohli Renu Arya Jyoti Gupta | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 7 |
| 2 | Hepatocellular Carcinoma and the Role of Liver Transplantation:A Review显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer deaths worldwide and liver transplantation(LT)is the only potentially curative treatment.Over the years,Milan criteria has been used for patient selection.There is ongoing research in this field with introduction of new biomarkers for HCC that can help guide future treatment.Furthermore,newer therapies for downstaging of the tumor are being implemented to prevent dropout from the transplant list.In addition,combination therapies for better outcome are under investigation.Interestingly,the concept of living-donor LT and possible use of hepatitis C virus-positive donors has been implemented as an attempt to expand the organ pool.However,there is a conflict of opinion between different centers regarding its efficacy and data is scarce.The aim of this review article is to outline the various selection criteria for LT,discuss the outcomes of LT in HCC patients,and explore future directions of LT for HCC.Therefore,a comprehensive PubMed/MEDLINE review was conducted.To expand our search,references of the retrieved articles were also screened for additional data.After selecting the studies,the authors independently reviewed them to identify the relevant studies.After careful evaluation 120 studies relevant to out topic are cited in the manuscript.Three tables and two figures are also included.In conclusion LT for HCC has evolved over the years.With the introduction of several expanded criteria beyond Milan,the introduction of bridging therapies,such as transcatheter arterial chemoembolization and radiofrequency ablation,and the approval of newer systemic therapies,it is evident that there will be more LT recipients in the future.It is promising to see ongoing trials and the continuous evolution of protocols.Prospective studies are needed to guide the development of a pre-LT criteria that can ensure low HCC recurrence risk and is not overly stringent,clarify the role of LDLT,and determine the optimal bridging therapies to LT. | Haris Muhammad Aniqa Tehreem Peng-Sheng Ting Merve Gurakar Sean Young Li Cem Simsek Saleh A.Alqahtani Amy K.Kim Ruhail Kohli Ahmet Gurakar | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 7 |
| 3 | Laparoscopic liver resection for benign and malignant liver tumors显示文摘BACKGROUND:Laparoscopic liver resection is one of the most complex procedures in hepatobiliary surgery.In the last two decades,laparoscopic liver surgery has emerged as an option at major academic institutions.The purpose of this study is to describe the initial experience of minimally invasive liver resections at a non-academic institution. METHODS:We retrospectively reviewed medical records of patients undergoing laparoscopic liver resections between June 2006 and December 2009 at our center.Indications, technical aspects,and outcomes of these patients are described. RESULTS:Laparoscopic liver resection was attempted in 28 patients.Of these,27 patients underwent laparoscopic liver resection(22 total laparoscopic and 5 hand assisted)and one needed conversion to open surgery.Twenty patients had a benign lesion and 8 had malignant lesions.Three patients had multiple lesions in different segments requiring separate resections.The lesions were located in segments Ⅱ-Ⅲ(n=18), Ⅳ(n=3),Ⅴ-Ⅵ(n=9),and VII(n=1).Tumor size ranged from 1.5 cm to 8.5 cm.The surgical procedures included left lateral sectionectomy(n=17),left hepatectomy(n=2),sectionectomy (n=8),and local resections(n=4).Median operative time was 110 minutes(range 55-210 minutes),and the median length of hospital stay was 2.5 days(range 1-7 days).There was no perioperative mortality.One patient developed hernia at the site of tumor extraction requiring repair at 3 months. CONCLUSIONS:Laparoscopic liver resections can be safely performed in selected patients with benign and malignant liver tumors.With increasing experience,laparoscopic liver resections are likely to become a favorable alternative to open resection. | Ashish Singhal Vivek Kohli Nazih | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 7 |
| 4 | Giant cell tumor of the pancreas:a pathological diagnosis with poor prognosis显示文摘BACKGROUND: Giant cell tumors are rare and highly malignant tumors of the pancreas. Based on two distinct cell populations, they have been divided into two subtypes corresponding to the osteoclast-like giant cell tumor and the pleomorphic giant cell carcinoma of the pancreas. Distinctive imaging features of the tumors remain uncharacterized. Surgical removal is the only appropriate treatment for them, but responses to chemotherapy or radiotherapy remain undocumented. METHODS: Clinical, radiological, histopathologic, and immuno- histochemical features of two cases of giant cell tumor of the pancreas are presented along with a brief review of the literature. RESULTS: En-bloc resection was done successfully in both cases. The patient with an osteoclast-like giant cell tumor remained disease-free with no clinical or radiological evidence of recurrence at 6 months after surgery. However, the patient with the pleomorphic type died 4 months later due to diffuse pulmonary metastasis. CONCLUSIONS: En-bloc surgical resection is the only appropriate treatment for giant cell tumors. The overall prognosis of these tumors is poorer than that of pancreatic ductal adenocarcinoma, especially the pleomorphic type. More studies are required to document the management and outcomes of the tumors. | Ashish Singhal Stan S Shrago Vivek Kohli | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，4： | 4 |
| 5 | Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?显示文摘The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. | niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 6 | Androgen deprivation therapy-associated vasomotor symptoms显示文摘雄激素剥夺治疗(ADT ) 广泛地在局部地先进、变形的前列腺癌症的治疗被用作标准治疗。当有效时, ADT 与多重副作用被联系,包括减少的性欲,可勃起的机能障碍,糖尿病,肌肉音调的损失和改变的身体作文,骨质疏松症,类脂化合物变化,记忆损失, gynecomastia 和热闪光。为热闪光的治疗的文学的宽度在女人比那在男人是小得多的。当热闪光的神经质的治疗被显示了有效时,多重非神经质的药和治疗方法也被开发了。这篇文章在拿 ADT 的病人为热闪光的治疗考察当前的选择。 | Jason M Jones Manish Kohli Charles L Loprinzi | 2012 | Asian Journal of Andrology2012，14，2： | 4 |
| 7 | Cardiac Troponins I and T: Molecular Markers for Early Diagnosis, Prognosis, and Accurate Triaging of Patients with Acute Myocardial Infarction显示文摘 | Ram P. Tiwari Anubhav Jain Zakir Khan Veena Kohli R. N. Bharmal S. Kartikeyan Prakash S. Bisen | 2012 | Molecular Diagnosis & Therapy2012，，6： | 3 |
| 8 | Synthesis and measurement of structural and magnetic properties of K-doped LaCoO_3 perovskite materials显示文摘Polycrystalline La1-xKxCoO3(0 ≤ x ≤ 0.2) rare earth cobaltates have been synthesized by a solution combustion method using glycine as a fuel.The synthesized ceramic materials were characterized by powder X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),and magnetic measurements and studied for physical properties,such as photocatalytic activity.FTIR measurements in conjunction with XRD showed that phases beyond 10% K doping are accompanied by small amounts of impurities.Chemical titrations show the presence of Co4+ and account for the Co3+-Co4+ mixed-valency of the system.The parent LaCoO3 shows spin-glass transition at low temperatures,whereas doped samples show transition from spin-glass behavior to paramagnetic ordering on progressive doping of K. 'Mixed-conductor' nature of these ceramics positions them as viable candidates for solid oxide fuel cell(SOFC) applications. | Manjunath B.Bellakki C.Madhu Tobias Greindl Sandeep Kohli Patrick McCurdy V.Manivannan | 2010 | Rare Metals2010，29，5： | 3 |
| 9 | Multiple bilateral lower limb fractures in a 2-year-old child: previously unreported injury with a unique mechanism显示文摘Fall from height is a common cause of unintentional injuries in children and accounts for 6% of all trauma-related childhood deaths, usually from head injury. We report a case of a 2-year-old child with multiple fractures of the bilateral lower limbs due to this reason. A child fell from a height of around 15 feet after toppling from a balcony. He developed multiple fractures involving the right femoral shaft, right distal femoral epiphysis (Salter Harris type 2), right distal metaphysis of the tibia and fibula, and undisplaced Salter Harris type 2 epiphyseal injury of the left distal tibia. There were no head, abdominal or spinal injuries. The patient was taken into emergency operation theatre after initial management which consisted of intravenous fluids, blood transfusion, and splintage of both lower limbs. Fracture of the femoral shaft was treated by closed reduction and fixation using two titanium elastic nails. Distal femoral physeal injury required open reduction and fixation with K wires. Distal tibia fractures were closely reduced and managed nonoperatively in both the lower limbs. All the fractures united in four weeks. At the last follow-up, the child had no disability and was able to perform daily activities comfortably. We also proposed the unique mechanism of injury in this report. | Basant Repswal Anuj Jain Sunil Gupta Aditya Aggarwal Tushar Kohli Devendra Pathrot | 2014 | Chinese Journal of Traumatology2014，17，5： | 2 |
| 10 | Ciliated hepatic foregut cyst:an increasingly diagnosed condition显示文摘BACKGROUND:Ciliated foregut cysts of the liver are rare, with only 96 cases diagnosed since the first description in 1857.They are being increasingly diagnosed recently;the majority of the cases have been reported in the last 15 years. Although they bear a close resemblance to the simple cyst of the liver which has essentially a benign course,ciliated hepatic foregut cysts(CHFCs)can progress to malignancy with devastating consequences.It is imperative that this group of conditions be diagnosed and treated adequately. DATA SOURCES:This review includes discussion of the data from all the 96 reported cases from English and non-English literature.Analysis of the incidence rates, embryogenesis,growth,clinical features,risk of malignancy and the prognosis are highlighted systematically.The roles of various diagnostic modalities including ultrasound, CT,MRI,fine needle aspiration cytology(FNAC), immunohistochemistry and surgery are further discussed. RESULTS:The mean age of patients with CHFC was 48± 12 years.The male/female ratio was 1.1∶1.The majority of patients with CHFC(62%)were asymptomatic,and the common mode of presentation was right upper abdominal pain.The cysts occurred in the left lobe in 51 patients, with sole location in segmentⅣin 44,and in the right lobe in 26.The average size of the cysts was 3.6±2.12 cm. The majority of the cysts were unilocular,and only 7 cases were multilocular.Cyst contents were described as viscous or mucinous in 73 patients,whereas bilious fluid was noted in 3.Large cysts having squamous carcinoma were cited in 3 patients,and 2 had extensive squamous metaplasia without malignancy.Others had benign histopathology. CONCLUSIONS:Clinicians have become increasingly aware of CHFC.Imaging alone is not diagnostic per se, but when considered in the context of the global picture does provide important clues to the diagnosis.FNAC is diagnostic by the presence of the ciliated columnar aspirate but lacks sensitivity.Infantile presentation is usually accompanied by biliary communication and mandates a different surgical approach.The demonstration of malignant transformation in 3 cases and its fatal course emphasizes the need for surgical resection in all cases once the diagnosis is made. | Sharad Sharma Amanda G.Dean Ayumi Corn Vivek Kohli Harlan I Wright Anthony Sebastian Nicolas Jabbour | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 2 |
| 11 | Mechanisms of Lipotoxicity in NAFLD and Clinical Implications显示文摘 | Samar H. Ibrahim Rohit Kohli Gregory J. Gores | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，2： | 2 |
| 12 | Formation and propeties of rare earth aluminosilicate glasses显示文摘 | Kohli J T Shelby J E | 1991 | Phy Chem Glasses1991，32，2： | 1 |
| 13 | Allelopathic interactions and allel- ochemicals: new possibilities for sustainable weed manage-ment 显示文摘 | Singh H P Batish D R Kohli R K | 2003 | Critical Rev Plant Sci2003，22，： | 1 |
| 14 | Market Orientation: The Construct, Research Propositions, and Managerial Implications 显示文摘 | KOHLI A K JAWORSKI B J | 1990 | Journal of Marketing1990，54，2： | 1 |
| 15 | Market orientation:antecedents and consequences显示文摘 | Jaworski B J Kohli A K | 1993 | Journal of Marketing1993，57，3： | 1 |
| 16 | Performance impacts of information technology:Is actual usage the missing link?显示文摘 | DEVARAJ S KOHLI R | 2003 | Management Science2003，49，3： | 1 |
| 17 | Allelopathy and Its Implications in Agroecosystems显示文摘 | KOHLI R K BATISH D SINGH H P | 1998 | Crop Prot1998，，1： | 1 |
| 18 | Curcumin: a natural anti-inflammatory agent显示文摘 | KOHLI K ALl J ANSARI M J | 2005 | Indian J Pharmcol2005，37，： | 1 |
| 19 | Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats显示文摘 | Fu WJ Haynes TE Kohli R | 2005 | J Nutr2005，135，4： | 1 |
| 20 | Market Orientation:Review,Reftnement,and Roadmap显示文摘 | JAWORSKI BERNARD J KOHLI AJAY K | 1996 | Journal of Market Focused Management1996，1，： | 1 |
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