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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Tree diversity and nectar composition affect arthropod visitors on extrafloral nectaries in a diversity experiment显示文摘Aims Plants with extrafloral nectaries(EFNs)are common in tropical and subtropical habitats and,despite many other arthropods also forage for EFN,most studies solely focused on the defense mutualisms between EFN plants and ants.This study aims at a quantitative assessment of the entire arthropod community that visits EFN trees to compare visitor communities between different tree species to disentangle the mechanisms that may drive EFN visitor community composition.We also test for tree diversity effects on EFN visitors,as it is unknown if local tree species richness relates to the abundance and species richness of arthropods foraging for EFN.Methods We sampled EFN-visiting arthropods in the experimental tree species richness gradient of the BEF-China Experiment,the currently largest forest diversity experiment in the world,and tested if tree species richness affects EFN visitors and if visitor community composition differs between EFN tree species.In a second step,we analyzed the EFN of Ailanthus altissima and Triadica cochinchinensis,the two EFN tree species with highest visitor abundance,for sugars and amino acids(AA)to test if tree species-specific differences in nectar chemistry translate to differing visitor communities.Lastly,we conducted a choice experiment using different artificial nectar solutions to test if nectar quality affects foraging decisions of ants,the most frequent EFN visitors in our study sites.Important Findings EFN trees in young successional forests in subtropical South-East China are visited by a diverse assemblage of arthropods including ants,beetles,flies,and spiders.Albeit ants accounted for about 75%of all individuals,non-ant visitors were by far more species rich.Visitor abundance and species richness declined with increasing tree species richness,suggesting a resource dilution effect,because plots with more tree species had proportionally less EFN tree individuals and thus lower nectar availability.Ailanthus altissima and T.cochinchinensis were visited by different arthropods and their nectar had species-specific AA composition and sugar concentration,indicating that differences in visitors may,at least partly,be explained by differences in nectar chemistry.These findings are supported by the choice experiment,in which artificial nectars containing sugar solutions supplemented with essential AAs attracted more ants than pure sugar solutions or sugar solutions supplemented with non-essential AAs.Our results improve the understanding of the complex ecology of EFN trees,a plant life form that might be crucial for understanding how tree diversity influences patterns of tree growth in young successional tropical and subtropical forests. | Michael Staab Joel Methorst Jan Peters Nico Blüthgen Alexandra-Maria Klein | 2017 | Journal of Plant Ecology2017，10，1： | 6 |
| 3 | Retroperitoneal laparoscopic nondismembered pyeloplasty for uretero-pelvic junction obstruction due to crossing vessels: A matched-paired analysis and review of literature显示文摘Objective:To compare laparoscopic Anderson-Hynes pyeloplasty(LAHP)and retroperitoneal laparoscopic YV-pyeloplasty(LRYVP)in ureteropelvic junction obstruction(UPJ)in presence of a crossing vessels(CV).Methods:Our database showed 380 UPJO-cases,who underwent laparoscopic retroperitoneal surgery during the last 2 decades including 206 non-dismembered LRYVP,157 dismembered pyeloplasties LAHP,and 17 cases of laparoscopic ureterolysis.Among them 198 cases were suitable for a matched-pair(2:1)analysis comparing laparoscopic retroperitoneal non-dismembered LRYVP(Group 1,n Z 131)and dismembered LAHP(Group 2,n Z 67)in presence of a crossing vessel.Patients were matched according to age,gender,kidney functions,and obstruction grade.Complications were graded according to modified Clavien-classification.Results:Comparative data were similar between both groups(LRYVP vs.LAHP)including mean operating time(112 min vs.114 min),complication rates(4.2%vs.7.3%)mainly Grade 1e2 according to Clavien classification,and success rates(90%vs.89%).These results reflected in the reviewed literature indicate that LRYVP provides the advantage of minimal dissection in case of CV with similar outcome.However,redundant pelvis and anteriorly crossing vessels still require a dismembered pyeloplasty LAHP.Conclusion:LRYVP has achieved similar results compared with the previous golden standard of open surgery,especially in case of crossing vessels apart from presence of a redundant pelvis or anteriorly crossing vessel.This can be further improved when using the small access retroperitoneoscopic technique respectively mini-laparoscopy. | Jens Rassweiler Jan Klein Ali Serdar Goezen | 2018 | Asian Journal of Urology2018，5，3： | 5 |
| 4 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 5 | Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression显示文摘Background: SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation;therefore, the importance of the ooplasmic SIRT1 pool for the further fate of mature oocytes has been strongly suggested. We hypothesised that SIRT1 plays the role of a signalling molecule in mature oocytes through selected epigenetic and non-epigenetic regulation.Results: We observed SIRT1 re-localisation in mature oocytes and its association with spindle microtubules.In mature oocytes, SIRT1 distribution shows a spindle-like pattern, and spindle-specific SIRT1 action decreasesα-tubulin acetylation. Based on the observation of the histone code in immature and mature oocytes, we suggest that SIRT1 is mostly predestined for an epigenetic mode of action in the germinal vesicles(GVs) of immature oocytes. Accordingly, BML-278-driven trimethylation of lysine K9 in histone H3 in mature oocytes is considered to be a result of GV epigenetic transformation.Conclusions: Taken together, our observations point out the dual spatiotemporal SIRT1 action in oocytes,which can be readily switched from the epigenetic to non-epigenetic mode of action depending on the progress of meiosis. | Jan Nevoral Lukas Landsmann Miriam Stiavnicka Petr Hosek Jiri Moravec Sarka Prokesova Hedvika Rimnacova Eliska Koutna Pavel Klein Kristyna Hoskova Tereza Zalmanova Tereza Fenclova Jaroslav Petr Milena Kralickova | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 6 | Genetic determinants of volatile-thiol release by Saccharomyces cerevisiae during wine fermentation 显示文摘 | Kate S Howell Mathias Klein Jan H Swiegers | 2005 | Appl Environ Microbiol2005，71，9： | 1 |
| 7 | MHC, TSP, and the Origin of Species: From Immunogenetics to Evolutionary Genetics显示文摘 | Jan Klein Akie Sato Nikolas Nikolaidis | 2007 | Annual Review of Genetics2007，，： | 1 |
| 8 | The Effect of Atmospheric Carbon Dioxide Elevation on Plant Growth in Freshwater Ecosystems显示文摘 | Peter Schippers Jan E. Vermaat Jeroen de Klein Wolf M. Mooij | 2004 | Ecosystems2004，，1： | 1 |
| 9 | Point cloud surfaces using geometric proximity graphs 显示文摘 | Jan Klein Gabriel Zachmann | 2004 | Computers & Graphics2004，28，1： | 1 |
| 10 | Modelling collective decision making in groups and crowds: Integrating social contagion and interacting emotions, beliefs and intentions显示文摘 | Tibor Bosse Mark Hoogendoorn Michel C. A. Klein Jan Treur C. Natalie Wal Arlette Wissen | 2013 | Autonomous Agents and Multi-Agent Systems2013，，1： | 1 |
| 11 | Morphometric and geological conditions for sediment accumulation in the Udava River, Outer Carpathians, Slovakia显示文摘在河隧道的沉积的累积是是的现象不仅由隧道形态学,而且由物理、地理的特征和发生在集水的内长、外长的过程影响了。这份报纸论述处于 lithological 条件的变化穿上的影响的分析词法并且到河的隧道累积形式代表的 Udava 河隧道和他们的关系的 morphometric 参数象它的平面形状一样的纵的侧面。当累积形式发生时,结果记录并且是他们在纵、代表性的河以内的空间分发的,介绍。更抵抗的结构与沉积的更低的度创造了节,当在消沉片断沉积的度是更高的时。随纵的斜坡的增加,平均隧道酒吧尺寸上的隧道宽度的影响增加了。另外,在累积的差别在能被 Coriolis 力量的影响可能解释的左、正确的河岸之间被观察。 | BARABAS Dusan BONA Jan KLEIN Daniel BALAZOVICOVA Lenka | 2017 | Journal of Geographical Sciences2017，27，8： | 1 |
| 12 | Influence of tetrachloroethylene on the biota of aquatic systems: Toxicity to phyto- and zooplankton species in compartments of a natural pond显示文摘 | Jan P. Lay Wulfram Schauerte Werner Klein Friedhelm Korte | 1984 | Archives of Environmental Contamination and Toxicology1984，，2： | 1 |
| 13 | Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways 显示文摘 | Braunstahl GJ Overbeek SE Klein Jan A | 2001 | J Allergy Clin Immunol2001，107，3： | 1 |
| 14 | Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series显示文摘 | Julia Brinkmann Karsten Heusser Bernhard M. Schmidt Jan Menne Gunnar Klein Johann Bauersachs Hermann Haller Fred C. Sweep Andre Diedrich Jens Jordan Jens Tank | 2012 | Hypertension2012，，6： | 1 |
| 15 | A molecule bearing an immunoglobulin-like V region of the CTX subfamily in amphioxus显示文摘 | Akie Sato Werner E. Mayer Jan Klein | 2003 | Immunogenetics2003，，6： | 1 |
| 16 | George Snell's First Foray Into the unexplored Territory of the Majar Hiotocompatibieity Complex显示文摘 | Jan Klein | 2001 | Genetics2001，159，： | 1 |
| 17 | Infusion of CD133+ Bone Marrow–Derived Stem Cells After Selective Portal Vein Embolization Enhances Functional Hepatic Reserves After Extended Right Hepatectomy: A Retrospective Single-Center Study显示文摘 | Jan Schulte am Esch Moritz Schmelzle Günther Fürst Simon C. Robson Andreas Krieg Constanze Duhme Roy Y. Tustas Andrea Alexander Hans M. Klein Stefan A. Topp Johannes G. Bode Dieter H?ussinger Claus F. Eisenberger Wolfram Trudo Knoefel | 2012 | Annals of Surgery2012，，1： | 1 |
| 18 | United airways : circulating Th2 effeetor cells in an allergic rhinitis model are re- sponsible for promoting lower airways inflammation显示文摘 | Klein Jan A Willart M van Nimwegen M | 2010 | Clin Exp Allergy2010，40，3： | 1 |
| 19 | Mechani- cal Simulators for Training for Laparoscopic Surgery in U- rology显示文摘 | Jens Rassweiler Jan Klein Dogu Teber | 2007 | J Endourology2007，21，3： | 1 |
| 20 | In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma 显示文摘 | van Rijt L S Steffen Jung Alex Klein Jan | 2005 | J Exp Med2005，201，6： | 1 |
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