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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Recent progress in pancreatic cancer显示文摘 | Christopher L. Wolfgang Joseph M. Herman Daniel A. Laheru Alison P. Klein Michael A. Erdek Elliot K. Fishman Ralph H. Hruban | 2013 | CA A Cancer Journal for Clinicians2013，，5： | 7 |
| 3 | Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention显示文摘Chronic granulomatous disease(CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years(95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease(IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis(UC) and end up having a colectomy. In this case report, we described a patient who had been followedup for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency. | Daniel Kotlarz Odul Egritas Gurkan Zehra Sule Haskologlu Ozgur Ekinci Aysel Aksu Unlusoy Neslihan Gürcan Kaya Jacek Puchalka Cristoph Klein Buket Dalgic | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 2 |
| 4 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 5 | Exploring the limits of complexity: A survey of empirical studies on graph visualisation显示文摘For decades,researchers in information visualisation and graph drawing have focused on developing techniques for the layout and display of very large and complex networks.Experiments involving human participants have also explored the readability of different styles of layout and representations for such networks.In both bodies of literature,networks are frequently referred to as being‘large’or‘complex’,yet these terms are relative.From a human-centred,experiment point-of-view,what constitutes‘large’(for example)depends on several factors,such as data complexity,visual complexity,and the technology used.In this paper,we survey the literature on human-centred experiments to understand how,in practice,different features and characteristics of node–link diagrams affect visual complexity. | Vahan Yoghourdjian Daniel Archambault Stephan Diehl Tim Dwyer Karsten Klein Helen C.Purchase Hsiang-Yun Wu | 2018 | Visual Informatics2018，2，4： | 2 |
| 6 | Emulsion terpolymerization of dimethyl meta-isopropenyl benzyl isocyanate with acrylic monomers:Process development and kineties显示文摘 | Mohammed S Daniels E S Klein A | 1996 | J Appl Polym Sci1996，61，： | 1 |
| 7 | Bulk copoly-merization of dimethyl meta-isopropenyl benzyl isocyanate (TMI): Determination of reactivity ratios 显示文摘 | Mohammed S Daniels E S Klein A | 1998 | Journal of Applied Polymer Science1998，67，3： | 1 |
| 8 | Patient and tumour biology predict survival beyond the M ilan criteria in liver transplantation for hepatocellular carcinoma显示文摘 | Andreas Andreou Safak Gül Andreas Pascher Wenzel Sch?ning Hussein Al‐Abadi Marcus Bahra Fritz Klein Timm Denecke Benjamin Strücker Gero Puhl Johann Pratschke Daniel Seehofer | 2015 | HPB2015，，2： | 1 |
| 9 | Adaptation of trypsin, chymotrypsin and α-amylase to casein level and protein source in Penaeus vannamei (Crustacea Decapoda)显示文摘 | Gilles Le Moullac Birgit Klein Daniel Sellos Alain Van Wormhoudt | 1996 | Journal of Experimental Marine Biology and Ecology1996，，1： | 1 |
| 10 | A comparison of nefazodone,the cognitive behavioral analysis system of psychotherapy,and their combination for the treatment of chronic depression显示文摘 | Martin B Keller James P McCullough Daniel N Klein | 2000 | New England Journal of Medicine2000，342，20： | 1 |
| 11 | Hydrogenation of styrene- butadiene rubber (SBR) latexes 显示文摘 | He Y Daniels ES Klein A | 1997 | J Appl Polym Sci1997，64，10： | 1 |
| 12 | Morphometric and geological conditions for sediment accumulation in the Udava River, Outer Carpathians, Slovakia显示文摘在河隧道的沉积的累积是是的现象不仅由隧道形态学,而且由物理、地理的特征和发生在集水的内长、外长的过程影响了。这份报纸论述处于 lithological 条件的变化穿上的影响的分析词法并且到河的隧道累积形式代表的 Udava 河隧道和他们的关系的 morphometric 参数象它的平面形状一样的纵的侧面。当累积形式发生时,结果记录并且是他们在纵、代表性的河以内的空间分发的,介绍。更抵抗的结构与沉积的更低的度创造了节,当在消沉片断沉积的度是更高的时。随纵的斜坡的增加,平均隧道酒吧尺寸上的隧道宽度的影响增加了。另外,在累积的差别在能被 Coriolis 力量的影响可能解释的左、正确的河岸之间被观察。 | BARABAS Dusan BONA Jan KLEIN Daniel BALAZOVICOVA Lenka | 2017 | Journal of Geographical Sciences2017，27，8： | 1 |
| 13 | Relationship Between Carotid Artery Stiffness and Retinal Arteriolar Narrowing in Healthy Middle-Aged Persons显示文摘 | Duanping Liao Tien Yin Wong Ronald Klein Daniel Jones Larry Hubbard A. Richey Sharrett | 2004 | Stroke: Journal of the American Heart Association2004，，4： | 1 |
| 14 | Genotypic and phenotypic resistance: longitudinal and sequential analysis of hepatitis B virus polymerase mutations in patients with lamivudine resistance after liver transplantation显示文摘 | Ziv Ben-Ari Nili Daudi Athalia Klein Jaqueline Sulkes Orit Papo Eytan Mor Zmira Samra Rachamim Gadba Daniel Shouval Ran Tur-Kaspa | 2003 | The American Journal of Gastroenterology2003，，1： | 1 |
| 15 | Hydrogenation of styrene butadiene rubber(SBR)latexes显示文摘 | He Y Daniels ES Klein A | 1997 | Appl Polym Sci1997，64，10： | 1 |
| 16 | Seeded emulsion terpolymerization of dimetyl meta-isopropenyl benzyl isocyanate (TMI) with acrylia monomers 显示文摘 | Mohammed S Daniels E S Klein A | 1998 | Journal of Applied Polymer Science1998，67，4： | 1 |
| 17 | Elastomeric films from structured latexes 显示文摘 | He Y Daniels E S Klein A | 1997 | J Appl Polym Sci1997，64，6： | 1 |
| 18 | Abstractions for software architecture and tools to support them 显示文摘 | Mary Shaw Robert DeLine Daniel V Klein | 1995 | IEEE Trans on Software Engineering Special Issue on software Architecture1995，21，4： | 1 |
| 19 | Breadth of human immunodeficiency virus-specific neutralizing activity in sera:clustering analysis and association with clinical variables显示文摘 | Doria-Rose NA Klein RM Daniels MG | 2010 | J Virol2010，84，3： | 1 |
| 20 | Immorality from Empathy-Induced Altruism: When Compassion and Justice Conflict显示文摘 | Batson C Daniel Klein | 1995 | Journal of Personality and Social Psychology1995，68，06： | 1 |
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