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| 1 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 2 | A delay-dependent approach to robust H∞ filtering for uncertain distributed delay systems显示文摘 | XU S JAM L | 2005 | IEEE Transactions on Signal Processing2005，53，10： | 1 |
| 3 | Induction of human endothelial cell growth by mildly oxidized low density lipoprotein 显示文摘 | Maier JAM Barenghi L Bradamante S | 1996 | Atheroscl1996，123，： | 1 |
| 4 | Bankruptcy prediction with industry effects 显示文摘 | Chava S Jam)w R A | 2004 | Re-view of Finance2004，8，4： | 1 |
| 5 | Robust H∞ filtering for uncertain discrete stochastic systems with time delays显示文摘 | XU S Y JAM J GAO H J ZOU Y | 2005 | Circuits Systems Signal Procession2005，24，6： | 1 |
| 6 | BDNF from microglia cau-ses the shift in neuronal anion gradient underlying neuropathic pain显示文摘 | Coull JAM Beggs S Boudreau D | 2005 | Nature2005，438，7070： | 1 |
| 7 | Identification of differentially expressed genes in esophageal squanlous cell carcinoma (ESCC) by cDNA expression array:overexpression of Fra-(1),Neogenin,Id-1,and CDC25B genes in ESCC显示文摘 | Hu YC Jam KY Law S | | 0，，08： | 1 |
| 8 | Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease显示文摘 | Rufaihah AJ Huang NF Jamé S | 2011 | Arterioscl Throm Vas2011，31，11： | 1 |
| 9 | AOT water-in-oil nucroemulsi ons as a penetration enhancerin transdermal drug delivery of 5- fluorouracil 显示文摘 | Gupta R R Jams S K Varslmey M | 2005 | Colloids Surf B : Biointerfaces2005，，41： | 1 |
| 10 | Antitu mour activity of mitoxantrone-loaded chitosan microspheres against Ehrlich ascites carcinime 显示文摘 | Jam meda S R Latha P G Subramoniam A | 1996 | J Pharm Pharmacol1996，48，： | 1 |
| 11 | High-lift low reynoldsnumber airfoil design 显示文摘 | MICHAEL S S JAMS J G | 1997 | Journal of Aircraft1997，34，1： | 1 |
| 12 | Design of a multi-band asymmetric patch antennal for wireless applications显示文摘 | Malekpoor H Jam S | 2013 | MicroOpt Technol Lett2013，55，4： | 1 |
| 13 | Catalyticdehydration of methanol to dimethyl ether catalyzed by a-luminum phosphate catalysts 显示文摘 | Yaripour F Mollavali M Jam S M e? al | 2009 | Energy Fuels2009，23，4： | 1 |
| 14 | Effects of blood viscosity on renin secretion显示文摘 | Chien S Jam KM | 1990 | Biorhology1990，27，34： | 1 |
| 15 | Seroprevalence of toxo- plasmosis in HIV(--)/AIDS patients in Iran显示文摘 | Mohraz M Mehrkhani F Jam S | 2011 | Acta Med I- ran2011，49，4： | 1 |
| 16 | Not all responses to breach are the same: The interconnection of social exchange and psychological contract processes in organizations 显示文摘 | Dulac T Coyle - Shapiro JAM Henderson D J Wayne S J | 2008 | The Academy of Management Journal2008，51，6： | 1 |
| 17 | Induction of human enodothlial cell growth by mildly oxidized low density lipoprotein显示文摘 | Barenghi L Bradamante S | 2004 | Atherosclerosis2004，123，： | 1 |
| 18 | Saccharide Sensing with Molecular Receptors Based on Boronic Acid 显示文摘 | Jams T D Samankumara K R A Shinkai S | 1996 | Angewandte Chemie-International Edition1996，35，17： | 1 |
| 19 | A second common mutation in the methylenetetrahydrofolate reductase gene:An additional risk factor for neural-tube defects显示文摘 | NMJ Vdp F G EMB S Jam S | 1998 | Am J Hum Genet1998，62，： | 1 |
| 20 | Anovel serum protein similar to Clq,produced exclusively in akipocytes显示文摘 | Scherer PE Will Jams S Fogliano M | 1995 | Biol Chem1995，270，45： | 1 |
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