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| 1 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 2 | Preparation of hoki (Johnius belengerii) bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase 显示文摘 | Won Kyo J Pyo Jam P Hee Guk B | 2005 | Pood Chemistry2005，，91： | 1 |
| 3 | Mechanisms of membrane toxicity of hydrocarbons 显示文摘 | Sikkema J Debont JAM Poolman B | 1995 | Microbiological Reviews1995，59，2： | 1 |
| 4 | 显示文摘 | Sikkema J De Bont JAM Poolman B | 1995 | Microbiol Rev1995，59，： | 1 |
| 5 | New reflector-backed Fresnel zone plate antenna using electromagnetic band gap显示文摘 | NEYESTANAK A A L JAM R J BIGLARBEGIAN B | 2010 | IET Microwave Antenna Propagation2010，4，7： | 1 |
| 6 | Screening of isolated lactic acid bacteria as potential beneficial strains for fermented liquid pig feed production显示文摘 | MISSOTTEN JAM GORIS J MICHIELS J | 2008 | Anim Feed Sci Teeh2008，150，： | 1 |
| 7 | Mechanisms of Membrane Toxicity of Hydrocarbons显示文摘 | Sikkema J de Bont JAM Poolman B | 1995 | Annual Review of Microbiology1995，59，： | 1 |
| 8 | Robust H∞ filtering for uncertain discrete stochastic systems with time delays显示文摘 | XU S Y JAM J GAO H J ZOU Y | 2005 | Circuits Systems Signal Procession2005，24，6： | 1 |
| 9 | The endo-beta-agarases AgaA and AgaB from the marine bacterium Zobellia galactanivorans: two paralogue enzymes with different molecular organizations and catalytic behaviours 显示文摘 | Jam M Flament D Allouch J | 2005 | Biochem J2005，385，： | 1 |
| 10 | Primary malignant lymphoma of the thyroid gland diagnosis and treatment tactics显示文摘 | Jam Ski Barczynaski M Rys J | 1997 | Przegl lek1997，54，2： | 1 |
| 11 | The influence of ruptured cerebral aneurysm localization on the blood flow velocity evaluated by transcranial Doppler ultrasonography 显示文摘 | Jams - Dziedzic K Bogucki J Zub W | 2001 | Neurol Res2001，23，1： | 1 |
| 12 | Screening of isolated lactic acid bacteria as potential beneficial strains for fermented liquid pig feed production显示文摘 | MISSOTTEN JAM GORIS J MICHIELS J | 2009 | Anita Feed Sei Teeh2009，150，12： | 1 |
| 13 | Preemptive analgesia in foot and ankle surgery显示文摘 | Frenchs J A Jams I R | 2003 | Clin Podiary Med Surg2003，20，2： | 1 |
| 14 | Development, Modeling and Evaluation of a (Laminar) Entrained Flow Reactor for the Determination of the Pyrolysis Kinetics of Polymers 显示文摘 | WESTERHOUT R W J KUIPERS JAM VANSWAAIJ WPM | 1996 | Chemical Engineering Science1996，51，10： | 1 |
| 15 | Characteristics andutilisation of copper slag - a review 显示文摘 | Gorai B Jam R K Premchand J R | 2003 | Resources Conservation and Recycling2003，39，4： | 1 |
| 16 | Bayesian statistical analysis for presence of single genes affecting meat quality traits in a crossed pig population显示文摘 | Jams L L G J Van Arendonk J A M Brascamp E W | 1997 | Geneties1997，145，： | 1 |
| 17 | Fetal fibronectin improves the accuracy of preterm labor显示文摘 | Jams J D Casal D Mcgregor JA | 1995 | Am J Obstect Gynecol1995，173，1： | 1 |
| 18 | High-lift low reynoldsnumber airfoil design 显示文摘 | MICHAEL S S JAMS J G | 1997 | Journal of Aircraft1997，34，1： | 1 |
| 19 | DU 127090:a highly potent, atypical dopamine receptor ligand- a putative potent full spectrum antipsychotic with low EPS potential显示文摘 | Van Vliet BJ Mos J Vander Heijden JAM | 2000 | Eur Neuropsychopharmacol2000，10，3： | 1 |
| 20 | A survey of armature transition mechanisms显示文摘 | Barber J P Bauer D P Jam ison K | 2003 | IEEE Transactions on Magnetics2003，39，1： | 1 |
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