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| 1 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 4 | Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy 显示文摘 | Christian W D Jorge E J Joseph S J | 1988 | Cardiovascular Research1988，22，： | 1 |
| 5 | Cavitation in anorifice flow显示文摘 | Dabiri S Sirignano W A Joseph D D | 2007 | Physics of Fluids2007，19，7： | 1 |
| 6 | U- Pb zircon and geochemical evidence for bimodal mid-Paleozoic magmatism and syngenetic base-metal mineralization in the Yukon-Tanana terrane,Alaska显示文摘 | Cynthia D B Joseph L W Melanie J H | | 0，，7： | 1 |
| 7 | Analyzing critical pathways with statistics显示文摘 | WALL D W JOSEPH E | 1993 | Quality Management Update1993，3，6： | 1 |
| 8 | Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene 显示文摘 | Joseph R Dou D Tsang W | 1995 | Brain Res1995，690，： | 1 |
| 9 | Direct detection of Chlamydia trachomatis in clinical speimens by a dot-immunobinding technique using monoclonal antibody 显示文摘 | Joseph J M Falker W A | 1988 | Immunol Methods1988，108，： | 1 |
| 10 | Neural network modeling of coastal algal blooms显示文摘 | JOSEPH H W LEE Y H MIKE D | 2003 | Ecological Modeling2003，159，23： | 1 |
| 11 | Hope or No-HOPE-- Merit-Based College Scholarship Status and Financial Behaviors Among College Students 显示文摘 | JOSEPH W D BRENDA J C | 2008 | Financial Counseling and Planning2008，，1： | 1 |
| 12 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 13 | A Hybrid thermopneumatic and electrostatic microvalve with integrated position sensing显示文摘 | JOSEPH A P KENSALL D W | 2012 | Micromachines2012，3，2： | 1 |
| 14 | The NCEP/NCAR 40-yeax reanalysis project 显示文摘 | E Kalnay M Kanamitsu R Kistler WCollins D Deaven L Gandin M Iredell S Saha G White J Woollen Y Zhu M Chelliah W Ebisuzaki W Higgins J Janowiak KC Mo C Ropelewski J Wang A Leetmaa R Reynolds R Jenne D Joseph | 1996 | Bulletin of the American Meteorological Society (S0003-0007)1996，77，3： | 1 |
| 15 | Direct and indirect effects of particulate matter on the cardiovascular system 显示文摘 | Nelin T D Joseph A M Gorr M W | 2012 | ToxicLett2012，208，3： | 1 |
| 16 | Tadpole size, cholinesterase activity, and swim speed in four frog species after exposure to sub-lethal con- centrations of chlorpyrlfos 显示文摘 | Pamela D W Joseph R B | 2008 | Aquatic Toxicology2008，88，1： | 1 |
| 17 | Tissue engineering of the anterior cruciate ligament using a braid-twist scaffold design显示文摘 | JOSEPH W F MIA D W CATO T L | 2007 | Journal of Biomechanics2007，40，： | 1 |
| 18 | Antimutagenic effect of rat small intestine in vitro on 1,1,2,3-tetrachloro- propene and 1,1,2,3,3-pentachloropropene 显示文摘 | Joseph S Patrick R D Michael W N | 1984 | Cancer Let- ters1984，22，3： | 1 |
| 19 | New formulation of the distributed Lagrange multiplier/fictitious domain method for particulate flows 显示文摘 | Patankar N A Singh P Joseph D D Glowinski R Pan T W | 2000 | International Journal of Multiphase Flow2000，26，9： | 1 |
| 20 | Increased uncoupling protein-2 levelsin cells are associated with impaired glucose-stimulated insulin secretion显示文摘 | Chan C B de Leo D Joseph J W | 2001 | Diabetes2001，50，： | 1 |
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