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| 1 | Role of functional imaging in the development and refinement of invasive neuromodulation for psychiatric disorders显示文摘Deep brain stimulation(DBS) is emerging as a pow-erful tool for the alleviation of targeted symptoms in treatment-resistant neuropsychiatric disorders. Despite the expanding use of neuropsychiatric DBS, the mecha-nisms responsible for its effects are only starting to be elucidated. Several modalities such as quantitative elec-troencephalography as well a intraoperative recordings have been utilized to attempt to understand the under-pinnings of this new treatment modality, but functional imaging appears to offer several unique advantages. Functional imaging techniques like positron emission tomography, single photon emission computed tomog-raphy and functional magnetic resonance imaging have been used to examine the effects of focal DBS on activ-ity in a distributed neural network. These investigations are critical for advancing the field of invasive neuro-modulation in a safe and effective manner, particularly in terms of defining the neuroanatomical targets and refining the stimulation protocols. The purpose of this review is to summarize the current functional neuroim-aging findings from neuropsychiatric DBS implantation for three disorders: treatment-resistant depression, obsessive-compulsive disorder, and Tourette syndrome. All of the major targets will be discussed(Nucleus ac-cumbens, anterior limb of internal capsule, subcallosal cingulate, Subthalamic nucleus, Centromedial nucleus of the thalamus-Parafasicular complex, frontal pole, and dorsolateral prefrontal cortex). We will also address some apparent inconsistencies within this literature, and suggest potential future directions for this promis-ing area. | Nolan R Williams Joseph J Taylor Kayla Lamb Colleen A Hanlon E Baron Short Mark S George | 2014 | World Journal of Radiology2014，6，10： | 6 |
| 2 | Current status of imaging in nonalcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is the most common diffuse liver disease, with a worldwide prevalence of 20% to 46%. NAFLD can be subdivided into simple steatosis and nonalcoholic steatohepatitis. Most cases of simple steatosis are non-progressive, whereas nonalcoholic steatohepatitis may result in chronic liver injury and progressive fibrosis in a significant minority. Effective risk stratification and management of NAFLD requires evaluation of hepatic parenchymal fat, fibrosis, and inflammation. Liver biopsy remains the current gold standard; however, non-invasive imaging methods are rapidly evolving and may replace biopsy in some circumstances. These methods include well-established techniques, such as conventional ultrasonography, computed tomography, and magnetic resonance imaging and newer imaging technologies, such as ultrasound elastography, quantitative ultrasound techniques, magnetic resonance elastography, and magnetic resonancebased fat quantitation techniques. The aim of this article is to review the current status of imaging methods for NAFLD risk stratification and management, including their diagnostic accuracy, limitations, and practical applicability. | Qian Li Manish Dhyani Joseph R Grajo Claude Sirlin Anthony E Samir | 2018 | World Journal of Hepatology2018，10，8： | 6 |
| 3 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 4 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 5 | Long-Term Outcomes for Patients with Post–Liver Transplant Anastomotic Biliary Strictures Treated by Endoscopic Stent Placement显示文摘 | Joseph Morelli Hugh E Mulcahy Ira R Willner John T Cunningham Peter Draganov | 2003 | Gastrointestinal Endoscopy2003，，3： | 2 |
| 6 | Leptospirosis: a zoonotic disease of global importance显示文摘 | Ajay R Bharti Jarlath E Nally Jessica N Ricaldi Michael A Matthias Monica M Diaz Michael A Lovett Paul N Levett Robert H Gilman Michael R Willig Eduardo Gotuzzo Joseph M Vinetz | 2003 | The Lancet Infectious Diseases2003，，12： | 2 |
| 7 | Studies on polyisobuty- lene bound paraphenylene diamine antioxidant in natural rubber 显示文摘 | Sulekha P B Joseph R George K E | 1999 | Polym Degrad Stab1999，63，2： | 1 |
| 8 | Validation of a sensitive LC-MS/MS method for the determination of zidovudine and lamivudine in human plasma显示文摘 | JOSEPH E R BRANDON K LANE R B | 2012 | Biomed Chromatogr2012，26，1： | 1 |
| 9 | Evolution of Femtosecond Pulse in Single-mode Fibers Having Higher-order Nonlinearity and Dispersion显示文摘 | ZHAO W JOSEPH R I | 1987 | Opt Lett1987，12，4： | 1 |
| 10 | Study of Chemical Structure on Friction and Wear: Part I-Vegetabile Oils and Esters 显示文摘 | David E Weller J R Joseph M Perez A | 2001 | Lubr Eng2001，57，3： | 1 |
| 11 | Neuronal death,cytoplasmic calcium and internucleosomal DNA fragmentation: evidence for DNA fragments being released from cells显示文摘 | Li W Han E | 1993 | Brain Res Mol Brain Res1993，17，12： | 1 |
| 12 | neuronal beta-amyloid precursor protein gene expression:regulation by aurintricarboxylic acid显示文摘 | Tsang W Han E | 1993 | Brain Res1993，625，2： | 1 |
| 13 | Optical distortion and birefringence in high power laser windows:Model and Computer Code显示文摘 | CHARLES E G GREGORY A N JOSEPH R J | 1985 | Applied Optics1985，24，17： | 1 |
| 14 | Exploring Pro- : Sex, Status, and Settings for Arousal and Avoidance Types 显示文摘 | Ferrari J R Doroszko E Joseph crastination in Corporate Settings E | 2005 | Indi- vidual Differences Research2005，，： | 1 |
| 15 | Knowledge-aided adaptive radar at DARPA:An overview显示文摘 | Joseph R Guerci E J Baranoski | 2006 | IEEE Signal Processing Magazine2006，23，1： | 1 |
| 16 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 17 | Exploring Procras- tination in Corporate Settings: Sex, Status, and Settings for Arousal and Avoidance Types显示文摘 | Ferrari J R Doroszko E Joseph E | 2005 | Individual Differ- ences Research2005，3，： | 1 |
| 18 | Retention and stability of the maxillary denture during function 显示文摘 | Jill R Joseph E Thomas G | 1995 | J Prosthet Dent1995，73，： | 1 |
| 19 | The relation of career-related work or internship experiences to the career devel-opment of college seniors显示文摘 | Brooks L Cornelius A Greenfield E Joseph R | | 0，，46： | 1 |
| 20 | Scaphotrapeziotrapeziod arthrodesis:a follow-up study显示文摘 | Watson HK Wollstein R Joseph E | | 0，，： | 1 |
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