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| 1 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Raster procedures for multi-criteria/multi-objective decisions显示文摘 | Eastman J R Jin W Kyem P A K | 1995 | Photogrammetric Engineering & Remote Sensing1995，61，5： | 1 |
| 4 | A perfect marker for fragrance genotyping in rice显示文摘 | Bradbury L M T Henry R J Jin Q S | 2005 | Molecular Breeding2005，16，： | 1 |
| 5 | Estimating Risk of Foreign Exchange Portfolio: Using VaR and CVaR based on GARCH-EVT-Copula Model 显示文摘 | Wang Z R Chen X H Jin Y B Zhou Y J | 2010 | Physica A2010，，359： | 1 |
| 6 | Application of three-dimensional hydrodynamic model for lake okeechobee显示文摘 | Jin K R Hamrick J H | 2000 | Journal of Dydraulic Engineering2000，126，10： | 1 |
| 7 | Airflow characteristics in the floor region of a slot ventilated room(isothermal) 显示文摘 | Jin Y Ogilvie J R | 1992 | Transactions of the ASAE1992，35，2： | 1 |
| 8 | Simultaneous strain and temperature measurement using a highly birefringence fi- ber loop mirror and a long-period grating written in a photonic crystal fiber显示文摘 | Zhao C L Zhao J R Jin W | 2009 | Optics Communication2009，282，： | 1 |
| 9 | An application of the electrochem- ical sulfur sensor in steelmaking 显示文摘 | Hong Y R Jin C J Li L S | 2002 | Sensors and Actuators B2002，87，： | 1 |
| 10 | Effects of zinc and soil moisture on photosynthetic rate and chlorophyll fluorescence parameters of maize显示文摘 | Wang H Liu R L Jin J Y | 2009 | Biologia Plantarum2009，53，1： | 1 |
| 11 | Treatment of Paenibacillus illinoisensis suppresses the activities of antioxidativeenzymes in pepper roots caused by Phytophthora capsici infection显示文摘 | Jung W J Jin Y L Park R D | 2006 | World Journal of Microbiology Biotechnology2006，22，： | 1 |
| 12 | Confirmation of PSORS psoriasis susceptibility loci in a Chinese population显示文摘 | Jin S Shi R | 2003 | Arch Dermatol Res2003，295，： | 1 |
| 13 | Ultrastructural comparison of penile cavernous tissue between hypertensive and normotensive rats 显示文摘 | Jiang R Chen JH Jin J | 2005 | Int J Impot Res2005，17，5： | 1 |
| 14 | Ultrastructural comparison of penile cavernous tissue between hypertensive and nor- motensive rats显示文摘 | Jiang R Chen JH Jin J | 2005 | Int J Impot Res2005，17，5： | 1 |
| 15 | Human cyclophilin B: A second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence显示文摘 | Price E R Zydowsky L D Jin M J | 1991 | Biochemistry1991，88，5： | 1 |
| 16 | Study of the desensitizing effect ofdifferent fullerene crystals on cyclotetramethylenetetranitra-mine ( HMX) 显示文摘 | Jin B Peng R Chu S J | 2008 | Propellants Explosives Pyrotechnics2008，33，6： | 1 |
| 17 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 18 | Performance and robustness of an anammox anaerobic baffled reactor subjected to transient shock loads显示文摘 | Jin R C Yu J J Ma C | 2012 | Bioresource Technology2012，114，： | 1 |
| 19 | Impact of heating on chemical compositions of green tea liquor显示文摘 | KIM E S LIANG Y R JIN J | 2007 | Food Chemistry2007，103，： | 1 |
| 20 | Cadmium is a mutagen that acts by inhibiting mismatch repair 显示文摘 | Jin Y H Clark A B Slebos R J | 2003 | Natural Genetic2003，34，3： | 1 |
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