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| 1 | Generation of new glutinous rice by CRISPR/Cas9-targeted mutagenesis of the Waxy gene in elite rice varieties显示文摘In rice, amylose content(AC) is controlled by a single dominant Waxy gene. We used Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/CRISPR-associated 9(Cas_9) to introduce a loss-of-function mutation into the Waxy gene in two widely cultivated elite japonica varieties. Our results show that mutations in the Waxy gene reduce AC and convert the rice into glutinous ones without affecting other desirable agronomic traits, offering an effective and easy strategy to improve glutinosity in elite varieties. Importantly, we successfully removed the transgenes from the progeny. Our study provides an example of generating improved crops with potential for commercialization, by editing a gene of interest directly in elite crop varieties. | Jinshan Zhang Hui Zhang Jose Ramón Botella Jian-Kang Zhu | 2018 | Journal of Integrative Plant Biology2018，60，5： | 49 |
| 2 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 3 | Ultra-high pressure metamorphism of granitic gneiss in the Yinggelisayi area, Altun Mountains, NW China显示文摘 | LIU Liang, SUN Yong, LUO Jinhai, WANG Yan, CHEN Danling & ZHANG Anda The Key Laboratory of Continental Dynamics, Ministry of Education,Department of Geology, Northwest University, Xi抋n 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 27 |
| 4 | 高脂饮食诱导的肠道微生物代谢障碍对精子发生和精子运动的损害显示文摘1973至2011年间西方国家男性精子密度快速下降50%以上,且当前无有效治疗方法减缓其下降趋势。越来越多的临床研究及动物实验表明,高脂饮食介导的肥胖、代谢综合征可以重塑肠道菌群,继而影响能量代谢、肠道黏膜屏障、宿主免疫、预防病原菌等生理功能。为了解高脂饮食是否通过肠道菌群影响男性生殖,该研究分别将正常饮食喂养的小鼠肠道菌群移植入6只正常饮食小鼠(组1),高脂饮食喂养的小鼠肠道菌群移植入另外6只正常饮食小鼠(组2)体内,15周后,检测到组2小鼠的精子生成、精子运动、曲细精管内精原干细胞数量、精母细胞数量均显著下降,血液内毒素升高近2倍,但组1小鼠的上述指标无明显改变。 | Ding N Zhang X Zhang XD 季文(编译) | 2020 | 中华医学杂志2020，100，26： | 25 |
| 5 | Natural killer cell-triggered vascular transformation:maternal care before birth?显示文摘Natural killer(NK)cells are found in lymphoid and non-lymphoid organs.In addition to important roles in immune surveillance,some NK cells contribute to angiogenesis and circulatory regulation.The uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental attachment sites.In species with invasive hemochorial placentation,these uterine natural killer(uNK)cells,via secretion of cytokines,chemokines,mucins,enzymes and angiogenic growth factors,contribute to the physiological change of mesometrial endometrium into the unique stromal environment called decidua basalis.In humans,uNK cells have the phenotype CD56^(bright) CD16^(dim) and they appear in great abundance in the late secretory phase of the menstrual cycle and early pregnancy.Gene expression studies indicate that CD56^(bright) CD16^(dim) uterine and circulating cells are functionally distinct.In humans but not mice or other species with post-implantation decidualization,uNK cells may contribute to blastocyst implantation and are of interest as therapeutic targets in female infertility.Histological and genetic studies in mice first identified triggering of the process of gestation spiral arterial modification as a major uNK cell function,achieved via interferon(IFN)-c secretion.During spiral arterial modification,branches from the uterine artery that traverse the endometrium/decidua transiently lose their muscular coat and ability to vasoconstrict.The expression of vascular markers changes from arterial to venous as these vessels dilate and become low-resistance,high-volume channels.Full understanding of the vascular interactions of human uNK cells is difficult to obtain because endometrial time-course studies are not possible in pregnant women.Here we briefly review key information concerning uNK cell functions from studies in rodents,summarize highlights concerning human uNK cells and describe our preliminary studies on development of a humanized,pregnant mouse model for in vivo investigations of human uNK cell functions. | Jianhong Zhang Zhilin Chen Graeme N Smith B.Anne Croy | 2011 | Cellular & Molecular Immunology2011，8，1： | 19 |
| 6 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 7 | 骨密度测量技术诊断骨质疏松的评价显示文摘骨矿密度(BMD)是诊断骨量减少(低骨量,骨质疏松),评价骨丢失率和疗效的重要客观指标。被世界卫生组织(WHO)用来定义骨质疏松(OP)的诊断标准。目前非创伤性骨密度测量方法主要有以下几种:X线光密度法(RA),单光子吸收法(SPA),双光子吸收法(DPA),双能x线吸收测定(DEXA),定量CT(QCT)。不同的测量方法的优、缺点和临床意义不同,在此简要综述几种BMD测量方法和特点。 | 张曼华 王保岚 YING N ZHANG FOUTZ | 2007 | 中国骨质疏松杂志2007，13，11： | 17 |
| 8 | Timing and geochemical characters of the Sanchazi magmatic arc in Mianlüe tectonic zone,South Qinling显示文摘The Sanchazi mafic-ultramafic complex in Mianlüe tectonic zone,South Qinling can be subdivided into two blocks,I.e.Sanchazi paleo-magmatic arc and Zhuangkegou paleo-oceanic crust fragment (ophiolite).The Sanchazi paleo-magmatic arc is mainly composed of ande-site,basaltic and basalt-andesitic gabbro(or diorite),andesitic dyke,plagiogranite and minor ul-tramafric rocks,which have typical geochemical features of island arc volcanic rocks,such as high field strength element(e.g.Nb,Ti)depletions and lower Cr,Ni contents.The Light rare earth element (LREE) and K enrichments of these rocks and zircon xenocrystals of 900 Ma from plagiogranite suggest that this magmatic arc was developed on the South active continental margin of the South Qinling micro-continent.The U-Pb age of (300±61) Ma for zircons from plagiogranite in-dicates that the Mianlüe paleo-oceanic crust was probably subducted underneath the South Qinling micro-continent in Carboniferous.This is consistent with the formation time (309Ma) of the Huwan eclogite originating form oceanic subduction in Dabie Mountains,suggesting that the Mianlüe paleo-ocean probably extended eastward to the Dabie Mountains in Carboniferous.The high-Mg adakitic rocks in Sanchazi paleo-magmatic arc suggest thet the subducted oceanic crust was relatively young (<25Ma) and hot. | LI Shuguang1, HOU Zhenhui1, YANG Yongcheng2, SUN Weidong1,1), ZHANG Guowei3, & LI Qiuli1 1. School of Earth and Space Sciences,University of Science and Technology of China ,Hefei 230026,China 2. Regional Geological Survey Team of Shaanxi Province,Xianyang 712000, China 3. Department of Geology, Northwest University,Xi抋n 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 16 |
| 9 | Inflammatory bowel disease in Hubei Province of China显示文摘InflammatoryboweldiseaseinHubeiProvinceofChinaXIABing1,S.SHIVANANDA2,ZHANGGuiShui1,YIJiYun1,JBACRUSIUS3andASPEN~A3Subjecthe... | XIA Bing 1, S. SHIVANANDA 2, ZHANG Gui Shui 1, YI Ji Yun 1, JBA CRUSIUS 3 and AS PE N~ A 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 12 |
| 10 | Geochemistry of the subduction-related magmatic rocks in the Dahong Mountains, northern Hubei Province--Constraint on the existence and subduction of the eastern Mianlüe oceanic basin显示文摘The existence and subduction of the eastern Mianl黣 oceanic basin in the south Qinling belt are keys to understand the Qinling orogen. Based on geological mapping, several volcanic slices have been identified in Tumen, Zhoujiawan, Xiaofu and Yuantan areas, which distribute in the northern margin of the Dahong Mountains (DHM), and thrust into the Sanli-gang-Sanyang fault. These slices consist mainly of diabases, basaltic-andesitic lavas, pyroclastic rocks and a minor tuff. The geochemistry of the basalts, andesites,and diabases is characterized by depleting in Nb and Ta, enriching in Th and LILE (e.g.K, Rb, Ba), and undifferentiating in HFSE. These geochemical characteristics suggest that the original magma of these rocks was derived from a mantle wedge above a subduction zone, and formed in an island-arc setting in Carboniferous-early Triassic. Comparing with the ophiolites and island-arc volcanic rocks in Mianxian-Leyang area to the west, it is reasonable to consider that there had been an oceanic basin connecting with the Mianle ancient ocean to the westward, distributing along the south edge of the Tongbai-Dabie block. In view of the ophiolite in Huashan area and these island-arc volcanic rocks along the north of the Dahong Mountains, it is suggested that there had been a plate tectonic evolutionary history with oceanic basin rifting and subduction in this region. | DONG Yunpeng, ZHANG Guowei, ZHAO Xia, YAO Anping & LIU Xiaoming The Key Laboratory of Continental Dynamics, Ministry of Education, Department of Geology, Northwest University, Xi抋n 710069,China | 2004 | Science China Earth Sciences2004，47，4： | 12 |
| 11 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 12 | Insulin improves cardiac myocytes contractile function recovery in simulated ischemia-reperfusion:Key role of Akt显示文摘The present study examined cardiac myocytecontractile and Ca2+ transient responses to insulin duringsimulated ischemia/reperfusion (I/R) and furtherinvestigated the role of protein kinase B (Akt) in the insulin-induced inotropic effect. Ventricular myocytes wereenzymatically isolated from adult Sprague-Dawley rats and perfused with Tyrode solution while electrically field-stimulated. Simulated I/R was induced by perfusing the cells with chemical anoxic solution including sodiumcyanide-sodium lactate for 15 min followed by reperfusionwith normal oxygenated Tyrode solution with or withoutinsulin. It is found that insulin only at concentration as high as 10 IU/L could increase cell shortening (16±5%, P < 0.05) in normal myocytes, whereas it concentration-dependently (0.01—10 IU/L) increased the contraction,the velocity ofshortening/releng- thening and Ca2+ transient in I/Rmyocytes. In addition, insulin treatment (1 IU/L) increasedAkt phosphorylation of I/R cardiomyocytes by 2.4-foldcompared with that of the control (P < 0.01). Mostimportantly, pretreatment with LY 294002, a specificinhibitor of phosphatidylinositol 3′-kinase (PI3-kinase), significantly inhibited both Akt phosphorylation and thepositive inotropic response to insulin in the I/Rcardiomyocytes. These results suggest that insulin exertsdirect positive inotropic effect by increasing Ca2+ transient of cardiomyocytes, which is enhanced in the pathologicalcondition of I/R. Akt activation plays an important role inthe insulin-induced improvement of myocyte contractile function following I/R. | ZHANG Bo, ZHANG Haifeng, FAN Qian, MA Xinliang & GAO Feng Department of Physiology, The Fourth Military Medical University,Xi抋n 710032, China Correspondence should be addressed to Gao Feng (e-mail: fgao@fmmu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，13： | 9 |
| 13 | Integrated positron emission tomography and computed tomography in preoperative lymph node staging of non-small cell lung cancer显示文摘 | Xu N Jiao Y Fang WG Wang MZ Zhu ZH Zhang YQ | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 14 | Theoretical prediction,synthesis,and crystal structure determination of new MAX phase compound V2SnC显示文摘Guided by the theoretical prediction,a new MAX phase V2SnC was synthesized experimentally for the first time by reaction of V,Sn,and C mixtures at 1000°C.The chemical composition and crystal structure of this new compound were identified by the cross-check combination of first-principles calculations,X-ray diffraction(XRD),energy dispersive X-ray spectroscopy(EDS),and high resolution scanning transmission electron microscopy(HR-STEM).The stacking sequence of V2C and Sn layers results in a crystal structure of space group P63/mmc.The a-and c-lattice parameters,which were determined by the Rietveld analysis of powder XRD pattern,are 0.2981(0)nm and 1.3470(6)nm,respectively.The atomic positions are V at 4f(1/3,2/3,0.0776(5)),Sn at 2d(2/3,1/3,1/4),and C at 2a(0,0,0).A new set of XRD data of V2SnC was also obtained.Theoretical calculations suggest that this new compound is stable with negative formation energy and formation enthalpy,satisfied Born-Huang criteria of mechanical stability,and positive phonon branches over the Brillouin zone.It also has low shear deformation resistance c44(second-order elastic constant,cij)and shear modulus(G),positive Cauchy pressure,and low Pugh’s ratio(G/B=0.500<0.571),which is regarded as a quasi-ductile MAX phase.The mechanism underpinning the quasi-ductility is associated with the presence of a metallic bond. | Qiang Xu Yanchun Zhou Haiming Zhang Anna Jiang Quanzheng Tao Jun Lu Johanna Rosén Yunhui Niu Salvatore Grasso Chunfeng Hu | 2020 | Journal of Advanced Ceramics2020，9，4： | 8 |
| 15 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 16 | Comparison of eastern paleo-Tethyan ophiolites and its geodynamic significance--Evidence from Dur'ngoi ophiolite显示文摘Nd-Pb isotopic geochemistry of metabasalt from Dur抧goi ophiolite, Qinghai Prov-ince, NW China reveals the presence of DMM mixing with EMII components in its upper mantle source, which is comparable with present Indian MORB. Comparisons indicate that the geo-chemistry, chronology and source characteristics of Dur抧goi ophiolite coincide with Pa-leo-tethyan ophiolites from 揝anjiang?area. Together with evidences from regional geology in adjacent areas, this study proves that independent paleo-tethyan basins evolved contemporarily, the dynamics of which is attributed to the interaction of mantle plume with over-riding lithosphere. | CHEN Liang1,2, SUN Yong1,2, PEI Xianzhi2, Feng Tao2 & Zhang Guowei2 1. Open Laboratory of Continental Dynamics, Ministry of Education, Northwest University, Xi抋n 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2004 | Science China Earth Sciences2004，47，4： | 7 |
| 17 | Appearance of an inhibitory cell nuclear antigen in rat and human serum during variable degrees of hepatic regenerative activity显示文摘METHODSInanimalstudies,adultmaleSpragueDawleyrats(n=3-4/group)weresacrificedat0,12,24,36,48,72and96hoursfollowing70%partia... | N Assy 1,2 ,YW Gong 3,M Zhang 3 and GY Minuk 3,4 | 1999 | World Journal of Gastroenterology1999，5，2： | 6 |
| 18 | Phase recovery and holographic image reconstruction using deep learning in neural networks显示文摘Phase recovery from intensity-only measurements forms the heart of coherent imaging techniques and holography.In this study,we demonstrate that a neural network can learn to perform phase recovery and holographic image reconstruction after appropriate training.This deep learning-based approach provides an entirely new framework to conduct holographic imaging by rapidly eliminating twin-image and self-interference-related spatial artifacts.This neural network-based method is fast to compute and reconstructs phase and amplitude images of the objects using only one hologram,requiring fewer measurements in addition to being computationally faster.We validated this method by reconstructing the phase and amplitude images of various samples,including blood and Pap smears and tissue sections.These results highlight that challenging problems in imaging science can be overcome through machine learning,providing new avenues to design powerful computational imaging systems. | Yair Rivenson Yibo Zhang Harun Günaydın Da Teng Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 19 | The Effects of the Chemical Components of Soil Salinity on Electrical Conductivity in the Region of the Delta Oasis of Weigan and Kuqa Rivers,China显示文摘In order to assess the effects of chemical properties of soil salinity on electrical conductivity of 1:5 soil/water extract (EC1:5), the study focused on revealing the main chemical factors contributing to EC of soil extracts and their relative importance. The relationship between EC1:5 and the chemical properties of soil salinity in the delta oasis of Weigan and Kuqa rivers, China, were studied using path coefficient analysis, a path analysis method. We studied each key element affecting EC1:5 either directly or indirectly. The results obtained show that the salt content, total dissolved solids (TDS), and the sum of the sodium ion concentration and the kalium ion concentration are the most influential factors on 1:5 soil/ water extract (EC1:5) in the 0-10 cm and the 30-50 cm soil layer. The results show that the sequence of direct path coefficients in the 0-10 cm and the 30-50 cm soil layers on soil conductivity is TDS→Na+ + K+→Salt content→Ca2+→Cl-→the sodium dianion ratio (SDR)→pH→SO42-→HCO3-→Mg2+→the soluble sodium percentage (SSP)→sodium absorption ratio (SAR) and TDS→Salt content→Na+ + K+→Ca2+→SDR→Mg2+→HCO3-→SSP→pH→SO42-→SAR→Cl-. The salt content, chlorine ion, and SAR are the main factors affecting 1:5 soil/water extract (EC1:5) in the 10-30 centimeter soil layer. The order of direct path coefficients result is as follows: Salt content→Cl-→SAR→SSP→TDS→Ca2+→Mg2+ = SO42-→HCO3-→pH→SDR→Na+ + K+. Moreover, the effects of HCO3-, pH were very weak. Though the direct path coefficients between EC1:5 and SAR, SO42- and Ca2+ were not high, influence of other chemical factors caused the coefficients to increase, making the summation of their direct and indirect path coefficients relatively high. The models of the different soil layers were structured separately. Evidences showed that multiple regression relations between EC1:5 and most of the primary factors had sound reliability and very good accuracy. The research results can serve as a reference to the scientific management amelioration and utilization of saline in the Delta Oasis of Weigan and Kuqa rivers. | ZHANG Fei Tashpolat Tiyip DING Jian-li Gregory N Taff HE Qi-sheng | 2009 | Agricultural Sciences in China2009，8，8： | 4 |
| 20 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
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