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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 3 | Optical properties of evaporated iridium in the vacuum ultraviolet from 500 Angstroms to 2000 Angstroms显示文摘 | HASS G JACOBUS G F HUNTER W R | 1967 | JOSA1967，57，6： | 1 |
| 4 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Andersen K H Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 5 | Evolution and ecology in coal mine,after the malaria genomes显示文摘 | Jacobus C Roode D Andrew F | 2003 | Trends in Ecology & Evolution2003，18，2： | 1 |
| 6 | Sequen- tial injection spectrophotometric determination of etile- frine hydrochloride 显示文摘 | BEYENE N STADEN W V JACOBUS F | 2004 | Ⅱ Farmaco2004，59，12： | 1 |
| 7 | Sequential injection spectrophotometric de- termination of trace amounts of iodide by its catalytic effect on the 4,4-methylenebis ( N, N-dimethylaniline)- chloramine-T reaction 显示文摘 | Zeriet O Tesfaldet Jacobus F van Staden Raluca I Stefan | 2004 | Talanta2004，64，： | 1 |
| 8 | Kinetics and mechanism of the oxidation of sulfur(IV) by ozone in aqueous solutions显示文摘 | Cornelus F B Julius H Jacobus J P | 1994 | Atmospheric Environment1994，28，20： | 1 |
| 9 | 1H-MR Spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jacobus F Walter H Klaas N | 2006 | Radiology2006，240，3： | 1 |
| 10 | 1H-MR Spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jacobus F Walter H Klaas N | 2006 | Radiology2006，240，3： | 1 |
| 11 | In vitro activity of cefoperazone-sulbactam against bacteroides species 显示文摘 | Dias M B S Jacobus N V Tally F P | 1986 | J Antimicrob Chemother1986，18，4： | 1 |
| 12 | 显示文摘 | ALEXANDER A R RALUCA I S JACOBUS F V S | 2004 | Talanta2004，64，： | 1 |
| 13 | In vitro activity of thienamycin显示文摘 | Tally F P Jacobus N V Gorbach S L | 1978 | Antimicrob Agents Chemother1978，14，3： | 1 |
| 14 | Spectrophotometric determination of mag nesium in pharmaceutical preparations by cost-ef{ec tive sequential injection analysis显示文摘 | Tesfaldet Zeriet O Van Staden Jacobus F Stefan Raluca I | 2004 | Talanta2004，64，98： | 1 |
| 15 | Application of porphyrins in flow - injection analysis : a review显示文摘 | Jacobus F van Staden Raluca I Stefan -van Staden | 2010 | Talanta2010，80，5： | 1 |
| 16 | Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone:calcium inflow and electrophysiological changes显示文摘 | Loss E S Jacobus A P Wassermann G F | 2011 | Life Sci2011，89，1516： | 1 |
| 17 | Invitroactivity of cefoperazon sulbactam against bacteroides species显示文摘 | Dias M B S Jacobus N V Tally F P | 1986 | J Antimicrob Chemother1986，18，： | 1 |
| 18 | Cyclic and static laboratory tests on Drammen clay 显示文摘 | Jacobus H P Stephen F B and Wim F R | 1980 | Journal of Geotechnical engineering Division1980，106，5： | 1 |
| 19 | Evolution and ecology in coal mine,after the malaria genomes显示文摘 | Jacobus C Roode D Andrew F | 2003 | Trends in Ecology & Evolution2003，18，2： | 1 |
| 20 | Cyclic and Static Laboratory Tests on Drammen Clay显示文摘 | AndersenK H Jacobus H P Stephen F B | 1980 | Journal of Geoteehnical Engineering Division1980，106，5： | 1 |
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