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| 1 | Optical Quality of the Eye with the Artisan Phakic Lens for the Correction of High Myopia显示文摘 | Isabelle Brunette MD Frcpc | 2003 | Optometry and Vision Science2003，80，2： | 1 |
| 2 | Optical Quality of the Eye with the Artisan Phakic Lens for the Correction of High Myopia显示文摘 | Isabelle Brunette MD Frcpc | 2003 | Optometry and Vision Science2003，80，2： | 1 |
| 3 | The Vision Health Research Network Annual Research Day,and International Symposium on Retinal and Choroidal Angiogenesis(Montreal)显示文摘The Vision Health Research Network of Québec(the Network)was established in 1995 and funded by the Fonds de la recherche du Québec en santé(FRQS).In the past 23 years,it has been the major venue to foster collaborations within Quebec’s research community and beyond.The Network aims to increase research capacity,improve infrastructure and enhance competitiveness of Quebec’s vision research on the international stage.Focusing on key matters proposed by Canadian health policy,the Network strikes to improve visual outcomes among patients. | Isabelle Brunette Sylvain Chemtob Tianwei Ellen Zhou | 2018 | Annals of Eye Science2018，，1： | 0 |
| 4 | AB081.Multi-unit ocular biometric system based on corneal shapes显示文摘Background:Our goal is to build a multi-unit ocular biometric system based on the fusion of left and right corneal shapes for identity authentication.Methods:Ocular biometrics such as iris,periocular,retina,sclera and eye movement have become established biometric traits,primarily due to extensive efforts made by the biometrics community in the field of iris recognition.In this work,we propose an ocular biometric trait based on the 3D shape of the cornea to improve biometric authentication.We show how the fusion of the left and right corneas can be used as a biometric trait for person recognition.First,we started by realizing our own cornea database by using a Pentacam Topographer(Oculus)which contains 288 corneal topographies of both eyes captured from 36 different people of different ages.For each eye,data acquisition was done during two different sessionsto establish the repeatability of the measurements over time.The time interval between the two sessions was equal or greater than one month.In each session;8 acquisitions(4 left eyes end 4 right eyes)were taken.Then,features were extracted by modeling the shape of the left and right corneas with a Zernike polynomial expansion.The fusion of the left and right shapes of cornea was performed at the matching score level using the weighted-sum rule.Results:For each individual,we had eight feature vectors(eight measures in two sessions)of size 36(Zernike polynomial coefficients)from their corneal topographies.The experimental results on our cornea database constructed for this study showed encouraging performance of the proposed ocular biometric system with Equal Error Rate decreasing to 1.38%with the weighted-sum rule compared to the analysis of the left(4.5%)or right(3.7%)cornea alone.Conclusions:The objective of this work was to investigate corneal topographyas an accurate biometric modality using shape discriminating features.Our idea was to propose an ocular multi-unit system based on the fusion of the left and right corneal shapes.The corneal feature extraction was done by Zernike polynomial decomposition.Multi-unit cornea fusion was performed at the matching score level to generate a unique score.This allowed a significative decrease of the EER to 1.38%. | Nassima Kihal Isabelle Brunette Jean Meunier | 2018 | Annals of Eye Science2018，，1： | 0 |
| 5 | AB086.Influence of the intraocular pressure on the expression of tight junctions in the corneal endothelium显示文摘Background:Cells are influenced by their environment.In vivo,the corneal endothelium is subjected to intraocular pressure(IOP).The purpose of this project was to evaluate in vitro,the effect of the IOP on the formation of tight junctions in the corneal endothelium.Methods:Cultivated corneal endothelial cells(P2-P3;n=6 populations)were seeded on devitalized on corneas(n=10 pairs).Native corneas and devitalized corneas were respectively used as positive(n=2 pairs)and negative controls(n=3 pairs).Corneas were placed in artificial anterior chambers and subjected to a hydrostatic pressure between 0.3 and 0.4 psi during 4-5 days.Unpressured control corneas were maintained in cell culture dishes.Pictures of the corneas were taken following the experiment to assess stromal transparency.Morphology,corneal thickness and distribution of ZO-1,n-cadherin,b-catenin,NaK ATPase pump and HCO3-cotransporter were evaluated by electron microscopy,histological staining and immunofluorescences.Results:Pressure treated corneas were more transparent than the controls.Thickness was accordingly reduced by 38.4%±4.9%for cultivated endothelium and 32.2%±2.7%for native endothelium.Negative controls change in transparency and thickness were marginal.Pressure treated cells showed none or at most marginal difference in morphology and expression of ZO-1,n-cadherin,b-catenin,NaK ATPase pump and HCO3-cotransporters and failed to recreate a phenotype similar to native corneas.Pressure however increased cortical localisation of the protein ZO-1 in both cultivated and native endothelium.Conclusions:These results suggest that anterior chamber hydrostatic pressure may enhance endothelial functionality by modulating the distribution of tight junction’s proteins. | Mathieu Thériault Olivier Roy Isabelle Brunette Stéphanie Proulx | 2018 | Annals of Eye Science2018，，1： | 0 |
| 6 | AB087.Corneal phenotype of a Slc4a11 knockout murine model for congenital hereditary endothelial dystrophy显示文摘Background:Congenital hereditary endothelial dystrophy(CHED)is characterized by blindness at birth or in early infancy resulting from bilateral corneal opacification,and is linked to mutation in the Slc4a11 gene.A Slc4a11 knockout(KO)mouse,generated by gene deletion(Vithana et al.Nat Genet 2006),was acquired in order to study this disease.To confirm the phenotype of this Slc4a11 KO mouse model as a function of age,using the wild type(WT)mouse as a control.Methods:Genotyping was performed by PCR(REDExtract-N-AmpTM Tissue PCR Kit,Sigma-Aldrich,Oakville,ON).Slc4a11 WT and KO mice populations aged from 5 to 50 weeks were studied(n=5 animals per age group;5-year age intervals).Slit lamp examination,anterior segment-ocular coherence tomography(OCT930SR;Thorlabs,Inc.,Newton,NJ),corneal endothelial cell staining,and scanning(SEM)and transmission(TEM)electron microscopy were used to assess the morphological and cellular differences between the two groups.The expression of basolateral membrane transporter NaBC1 within the corneal endothelium was also assessed using immunohistochemistry.Results:Diffuse and progressive corneal opacification was observed at the slit lamp in the Slc4a11 KO mice,starting at 10 weeks.The central corneal thickness(CCT)also increased progressively as a function of time.In comparison,Slc4a11 WT corneas remained clear over the entire study period.Early TEM results showed vacuole degeneration of the corneal endothelium in the 15-week KO mouse,which was not seen in the same age WT mouse.Conclusions:The corneal phenotype of this Slc4a11 KO mouse is representative of the clinical manifestations of CHED in human subjects,confirming the usefulness of this model for studying pathophysiology and therapeutic alternatives for Slc4a11-associated corneal dystrophies. | Sergiu Vlad Antoine Sylvestre-Bouchard Hasitha Alwis Weerasekera Rami Darwich Marilyse Piché Khampoun Sayasith Joseph Casey Isabelle Brunette | 2018 | Annals of Eye Science2018，，1： | 0 |
| 7 | AB092.Database for the anatomopathological,functional and surgical characterization of the cornea显示文摘Background:The purpose of this infrastructure is to provide to the Network researchers a database and diverse related tools for the anatomical and functional analysis of the normal,pathological and surgical cornea.Methods:This database is composed of normal and pathological individuals,totaling more than 36,000 patients.It includes anatomical and functional imaging data,physiological optics data,psychometric and clinical data(medical history,surgical parameters,acuteness,etc.).Various corneal topography tools were added,giving the database a unique character:tools for analyzing individual maps,average map tools for the study and comparison of populations,3D modeling and visualization tools,statistical tools,etc.There are also screening tools for detecting various corneal conditions(LASIK,PRK,RK,keratoconus)and for secure data exchange between colleagues.Results:Several studies were made in recent years thanks to this common infrastructure.For example,this database has provided important information regarding the evolution of the 3D shape of the normal cornea with age and ametropia and has confirmed the mirror symmetry of corneas for the right and the left eyes(enantiomorphism).The different stages of Fuchs’dystrophy were also characterized to provide essential knowledge for surgery of the posterior layer of the cornea.Our database also allowed studying the anatomy of the wounds and the shape of the cornea before and after a transfixing transplant or an endothelial transplant(DSAEK and DSEK).The data on the characterization of experimentally transplanted corneas with corneal equivalents generated by tissue engineering and the recent addition of clinical data on the replacement of a diseased cornea with a synthetic corneal equivalent(keratoprosthesis)also resulted in several publications.More recently,the database has allowed to develop innovative algorithms to determine the optimal shape of an implant according to the clinical parameters of the recipient.On the other hand,we also demonstrated that the 3D shape of the cornea can be used as a biometric characteristic(such as fingerprints)for identification of individuals for various applications ranging from forensics to secure border crossings.Consequently,a new multimodal database(cornea+iris+eventually retina)was created for the purpose of biometric identifications.This database provides a unique set of anatomical and functional tools for the analysis of the cornea.It is characterized by the scientific quality and large quantity of accumulated information on the cornea and the high-level tools to exploit its content.Conclusions:The common infrastructure is easily accessible to all VHRN members on request.The database will also be accessible online in 2018(see http://gffzz389a411c2b7240ffhqqqqvknqww6b6qqn.ffgz.tsg.suse.edu.cn for more information). | Jean Meunier Mona Dagher Julia Talajic Marie-Claude Robert Isabelle Brunette | 2018 | Annals of Eye Science2018，，1： | 0 |
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