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| 1 | Therapy with stem cells in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation(HSCT) has been used in application to severe refractory Crohn's disease(CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells(MSCs) have immune regulatory and regenerative properties, and low immunogenicity(both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD. | María del Pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 3 | Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration显示文摘The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may develop.One of them is age-related macular degeneration,which causes progressive loss of vision due to retina degeneration.Treatment of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation respectively.The phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor properties.This review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and E.This study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products. | Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-Solís | 2020 | Neural Regeneration Research2020，15，12： | 2 |
| 4 | Transient elastography to rule out esophageal varices and portal hypertensive gastropathy in HIV-infected individuals with liver cirrhosis显示文摘 | Maria L. Montes Ramirez Jose F. Pascual-Pareja Matilde Sánchez-Conde Jose I. Bernardino De la Serna Francisco X. Zamora Vargas Pilar Miralles Juan M. Castro Margarita Ramírez Isabel Gutierrez Juan Gonzalez-García Juan Berenguer Jose R. Arribas López | 2012 | AIDS2012，，14： | 1 |
| 5 | Microwave effect during aging on the porosity and basic properties 显示文摘 | Olga Bergada Isabel Vicente Pilar Salagre | 2007 | Microporous and Mesoporous Materials2007，101，3： | 1 |
| 6 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 7 | Preparation of pure hectorite using microwaves显示文摘 | ISABEL V PILAR S YOLANDA C | 2010 | Physics Procedia2010，8，： | 1 |
| 8 | Rural tourism demand by type of accommodation显示文摘 | ISABEL PILAR ALBALADEJO PINA MAP(I)A TERESA D(I)AZ DELFA | 2005 | Tourism Management2005，26，6： | 1 |
| 9 | Finite element simulation of thermal residual stress in joining ceramics with thin metal interlayer 显示文摘 | Kovalev Serguei Miranzo Pilar Osendi Maria Isabel | 1998 | Journal of the American Ceramic Society1998，81，9： | 1 |
| 10 | Antihypertensive Effects of Peroxisome Proliferator-Activated Receptor-β Activation in Spontaneously Hypertensive Rats显示文摘 | María José Zarzuelo Rosario Jiménez Pilar Galindo Manuel Sánchez Ana Nieto Miguel Romero Ana María Quintela Rocío López-Sepúlveda Manuel Gómez-Guzmán Elvira Bailón Isabel Rodríguez-Gómez Antonio Zarzuelo Julio Gálvez Juan Tamargo Francisco Pérez-Vizcaíno | 2011 | Hypertension2011，，4： | 1 |
| 11 | Loss of heterozygosity in BRCA1 and BRCA2 markers and high‐grade malignancy in breast cancer显示文摘 | Jose M. Silva Rocio Gonzalez Mariano Provencio Gema Dominguez Jose M. Garcia Isabel Gallego Jose Palacios Pilar Espa?a Felix Bonilla | 1999 | Breast Cancer Research and Treatment1999，，1： | 1 |
| 12 | miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction显示文摘 | Alberto Izarra Isabel Moscoso Elif Levent Susana Ca?ón Inmaculada Cerrada Antonio Díez-Juan Vanessa Blanca Iván-J. Nú?ez-Gil I?igo Valiente Amparo Ruíz-Sauri Pilar Sepúlveda Malte Tiburcy Wolfram-H. Zimmermann Antonio Bernad | 2014 | Stem Cell Reports2014，，： | 1 |
| 13 | A constitutive cystatin-encoding gene from barley (Icy) responds differentially to abiotic stimuli显示文摘 | Kamel Gaddour Jesús Vicente-Carbajosa Pilar Lara Inés Isabel-Lamoneda Isabel Díaz Pilar Carbonero | 2001 | Plant Molecular Biology2001，，5： | 1 |
| 14 | Performance of an anaerobic digester-constructed wetland system for a small community显示文摘 | PILAR B ISABEL R MANUEL S | 2008 | Ecological Engineering2008，，33： | 1 |
| 15 | Wild Type p73 Overexpression and High-Grade Malignancy in Breast Cancer显示文摘 | Gemma Dominguez Jose M. Silva Javier Silva Jose M. Garcia Antonio Sanchez Antonia Navarro Isabel Gallego Mariano Provencio Pilar Espa?a Felix Bonilla | 2001 | Breast Cancer Research and Treatment2001，，3： | 1 |
| 16 | Profiling Segments of Tourists in Rural Areas of South-Eastern Spain显示文摘 | aLourdes Molera Isabel Pilar Albaladejo | 2007 | Tourism Management2007，28，： | 1 |
| 17 | Protective Effect of Enriched Diet Plus Growth Hormone Administration on Radiation-Induced Intestinal Injury and on Its Evolutionary Pattern in the Rat显示文摘 | Isabel Vazquez Ignacio A. Gomez-De-Segura Antonio G. Grande Ana Escribano Pilar Gonzalez-Gancedo Alicia Gomez Rosa Diez Enrique De Miguel | 1999 | Digestive Diseases and Sciences1999，，11： | 1 |
| 18 | Superoxide Anion and Nitric Oxide in High-Grade Esophagitis Induced by Acid and Pepsin in Rabbits显示文摘 | Angel Lanas Fernando Soteras Pilar Jimenez Isabel Fiteni Elena Piazuelo Yolanda Royo Javier Ortego Pedro I?arrea Francisco Esteva | 2001 | Digestive Diseases and Sciences2001，，12： | 1 |
| 19 | Finite element simulation of thermal stresses in joining cremamics with thin metal interlayers显示文摘 | Kovalev Serguei P Miranzo Pilar Osendi Maria Isabel | 1998 | Journal of American Ceramic Society1998，81，9： | 1 |
| 20 | Profiling segments of tourists in rural areas of South - Eastern Spain显示文摘 | Lourdes Molera Isabel Pilar Albaladejo | 2007 | Tourism Management2007，，28： | 1 |
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