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| 1 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 2 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 3 | Evaluation of a speetrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function 显示文摘 | Gomez E Irvine D S Aitken R J | 1998 | Int J Androl1998，21，2： | 1 |
| 4 | Developmental analysis of elongation factor-1 expression in transgenic tobacco显示文摘 | URSIN V M IRVINE J M HIATT W R SHEWMAKER C K | 1991 | Plant Cell1991，3，6： | 1 |
| 5 | Suppression of avian influenza transmission in genetically modified chickens 显示文摘 | LYALL J IRVINE R M SHERMAN A | 2011 | Science2011，331，6014： | 1 |
| 6 | Assessing Basic Research:Some Partial Indicators of Scientific Progress in Radio Astronomy显示文摘 | Martin B R Irvine J | 1983 | Research Policy1983，12，： | 1 |
| 7 | A geometrical approach to conflict probability estimation显示文摘 | Irvine R | 2002 | Air Traffic Control Quarterly2002，10，2： | 1 |
| 8 | Production of in vitro matured oocytes from 6-week old calves显示文摘 | Earl C R Irvine B J Rowe J P | | 0，，： | 1 |
| 9 | 显示文摘 | Valenzuela R Irvine J T S | 1990 | J Appl Phys1990，，67： | 1 |
| 10 | A guide to the chemical classification of the common volcanic rocks 显示文摘 | Irvine I N Baragar W R A | 1971 | Canad J Earth Sci1971，8，： | 1 |
| 11 | Standardization of Spirometry, 1994 Update American Thoracic Society 显示文摘 | Crapo R O Hankinson J L Irvin C | 1995 | Am J Respir Crit Care Med1995，152，3： | 1 |
| 12 | Quality of life in inflammatory bowel disease显示文摘 | Love JR Irvine EJ Fedorak R | 1992 | Journal of Clinical Gastroenterology1992，14，1： | 1 |
| 13 | Oxidation of phenolic pollutants by a lignin degrading enzyme from the white-rotfungus Phanerochaete chrysosporium显示文摘 | AITKEN M D VENKATADRI R IRVINE R L | 1989 | Water Research1989，23，4： | 1 |
| 14 | Precipitation and recovery of whey proteins显示文摘 | HILL A R IRVINE D M BULLOCK D H | 1982 | Canadian Institute of Food Science and Technology1982，15，： | 1 |
| 15 | Gephsical exploration for epithermal gold deposits显示文摘 | Irvine R J Smith M J | 1990 | Journal of Geochemical Exploration1990，，36： | 1 |
| 16 | A guide to the chemical elassifi- cation of the common volcanic rocks显示文摘 | Irvine T N Earagar W R A | 1971 | Canadian Journal of Earth Sciences1971，8，5： | 1 |
| 17 | The effect of intermittent feeding on aerobic granule structure 显示文摘 | McSwain B S Irvine R L Wilderer P A | 2004 | Water Science and Technology2004，49，1112： | 1 |
| 18 | Pneumatic retinopexy:success rate and complications显示文摘 | Zaidi AA Alvarado R Irvine A | | 0，，： | 1 |
| 19 | Arsenobetaine and arsenocholine: two marine arsenic compounds without embryotoxicity 显示文摘 | Irvin T R Irgolic K J | 1988 | Appl Organomet Chem1988，2，： | 1 |
| 20 | The influence of settling time on the formation of aerobic granules显示文摘 | Mcswain B S Irvine R L Wilderer P A | 2005 | Water Science and Technology2005，50，10： | 1 |
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