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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 2 | 临床上有显著门静脉高压症的患者口服抗HCV药物治疗后的血流动力学变化及临床结果显示文摘【据Journal of Hepatology 2020年5月报道】题:临床上有显著门静脉高压症的患者口服抗HCV药物治疗后的血流动力学变化及临床结果(作者Lens S等)在使用直接抗病毒药物治疗的丙型肝炎肝硬化患者中,有显著临床意义的门静脉高压症(CSPH,HVPG≥10 mm Hg)在持续病毒学应答(SVR)24周后持续存在。这些患者仍有失代偿的风险。然而,长期配对的临床和血流动力学数据不适用于该人群。 | 武彤 辛桂杰 LENS S BAIGES A ALVARADO E | 2020 | 临床肝胆病杂志2020，36，9： | 8 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 5 | Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by fi rst-year medical students显示文摘BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia.METHODS: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each participant.RESULTS: We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2%(SD=0.145) with 82.9% of the class passing(score above 75.0%).CONCLUSION: Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for proficiency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound. | Jonathan B.Lee Christina Tse Thomas Keown Michael Louthan Christopher Gabriel Alexander Anshus Bima Hasjim Katrina Lee Esther Kim Luke Yu Allen Yu Shadi Lahham Steven Bunch Maili Alvarado Abdulatif Gari John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，4： | 4 |
| 6 | Noninvasive diagnosis of vulnerable coronary plaque显示文摘Myocardial infarction and sudden cardiac death are frequently the first manifestation of coronary artery disease.For this reason,screening of asymptomatic coronary atherosclerosis has become an attractive field of research in cardiovascular medicine.Necropsy studies have described histopathological changes associated with the development of acute coronary events.In this regard,thin-cap fibroatheroma has been identified as the main vulnerable coronary plaque feature.Hence,many imaging techniques,such as coronary computed tomography,cardiac magnetic resonance or positron emission tomography,have tried to detect noninvasively these histomorphological characteristics with different approaches.In this article,we review the role of these diagnostic tools in the detection of vulnerable coronary plaque with particular interest in their advantages and limitations as well as the clinical implications of the derived findings. | Eduardo Pozo Pilar Agudo-Quilez Antonio Rojas-González Teresa Alvarado María José Olivera Luis Jesús Jiménez-Borreguero Fernando Alfonso | 2016 | World Journal of Cardiology2016，8，9： | 4 |
| 7 | META-R:A software to analyze data from multi-environment plant breeding trials显示文摘META-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java language.The objective of META-R is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice designs.META-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense heritability.These parameters are very important in the selection of top performing genotypes in plant breeding.META-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical significance.The genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated traits.META-R performs multi-environment analyses by using the residual maximum likelihood(REML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability. | Gregorio Alvarado Francisco M.Rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-Rodríguez Marco A.Lopez-Cruz | 2020 | The Crop Journal2020，8，5： | 4 |
| 8 | Presacral venous bleeding during mobilization in rectal cancer显示文摘AIM To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal cancer.METHODS A review of the databases MEDLINE? and Embase? was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were defined.RESULTS This is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious complication.CONCLUSION A series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications. | Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador Ana María Gay Fernández Maria ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez | 2017 | World Journal of Gastroenterology2017，23，9： | 4 |
| 9 | Nitrate regulates rhizobial and mycorrhizal symbiosis in common bean(Phaseolus vulgaris L.)显示文摘Nitrogen‐limited conditions are considered to be a prerequisite for legume‐rhizobial symbiosis, but the effects of nitrate‐rich conditions on symbiotic status remain poorly understood. We addressed this issue by examining rhizobial(Rhizobim tropici) and arbusclarmycorrhizal(Glomus intraradices) symbiosis in Phaseolus vulgaris L. cv. Negro Jamapa under nitrate pre‐incubation and continuous nitrate conditions. Our results indicate that nitrate pre‐incubation, independent of the concentration, did not affect nodule development. However, the continuous supply of nitrate at high concentrations impaired nodule maturation and nodule numbers. Low nitrate conditions, in addition to positively regulating nodule number, biomass, and nitrogenase activity, also extended the span of nitrogen‐fixing activity. By contrast, for arbuscular mycorrhizae, continuous 10 and 50mmol/L nitrate increased the percent root lengthcolonization, concomitantly reduced arbuscule size, and enhanced ammonia transport without affecting phosphate transport. Therefore, in this manuscript, we have proposed the importance of nitrate as a positive regulator in promoting both rhizobial and mycorrhizal symbiosis in the common bean. | Kalpana Nanjareddy Lourdes Blanco Manoj‐Kumar Arthikala Xochitl Alvarado Affantrange Federico Sánchez Miguel Lara | 2014 | Journal of Integrative Plant Biology2014，56，3： | 3 |
| 10 | L-半胱氨酸在柠檬酸和氨基磺酸混合介质中对碳钢的缓蚀显示文摘采用电化学方法测定了L-半胱氨酸对A3碳钢在柠檬酸和氨基磺酸混合溶液中腐蚀行为的影响,开路电位(OCP)测定结果显示,加入L-半胱氨酸造成开路电位下降,初始L-半胱氨酸浓度越高,开路电位越高.电化学阻抗谱(EIS)测试结果显示,加入L-半胱氨酸后腐蚀反应阻抗越小,腐蚀速率增加.等效电路表明L-半胱氨酸吸附在铁的表面后促进铁和溶液界面中铁的电化学活性,并使得铁表面保护层的厚度降低,Tafel曲线显示加入L-半胱氨酸腐蚀速率增加.吉布斯自由能计算结果显示,L-半胱氨酸和铁离子形成配合物比L-半胱氨酸吸附在碳钢表面更容易发生,导致了铁的溶出,使腐蚀加剧. | 梁丽华 郑现明 José Alberto Alvarado 雷菁花 田园 | 2018 | 环境化学2018，37，4： | 2 |
| 11 | Comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients显示文摘BACKGROUND: The purpose of this study was to use point-of-care ultrasound(POCUS) to investigate the relationship between tobacco smoke exposure and the characteristics of the common carotid artery(CCA). The effect of both primary and secondary smoking on CCA properties was evaluated.METHODS: We performed a prospective cross-sectional study across 20 primary care clinics in Bandung, West Java, Indonesia in July 2016. Point of care ultrasound was performed on a convenience sample of Indonesian patients presenting to clinic. The CCA wall stiffness and carotid intima-media thickness(CIMT) were measured during diastole and systole. These measurements were correlated with smoke exposure and cardiovascular disease.RESULTS: We enrolled 663 patients in the study, with 426 patients enrolled in the smoking category and 237 patients enrolled in the second-hand smoke category. There was an overall positive correlation with the measured lifestyle factors and the ultrasound-measured variables in the group of individuals who smoked. For all variables, age seemed to contribute the most out of all of the lifestyle factors for the positive changes in CIMT and CCA wall stiffness.CONCLUSION: Our data yielded correlations between CCA properties and cardiovascular risk, as well as between CIMT and arterial stiffness. We were also able to demonstrate an increase in thickness of the CIMT in patients who have been exposed by tobacco through the use of ultrasound. Further large scale studies comparing patients with multiple cardiac risk factors need to be performed to confi rm the utility of ultrasound fi ndings of cardiovascular disease and stroke. | Allen R.Yu Bima Hasjim Luke E.Yu Christopher Gabriel Alexander Anshus Jonathan B.Lee Michael J. Louthan Esther C.Kim Katrina Lee Christina Tse Thomas Keown Shadi Lahham Maili Alvarado Steven Bunch Abdulatif Gari J.Christian Fox | 2017 | World Journal of Emergency Medicine2017，8，3： | 2 |
| 12 | 微生物抑制金属腐蚀机理的研究进展显示文摘传统金属防腐方法成本较高或者容易产生次生环境问题。微生物防腐蚀是一项新的绿色防腐技术,随着越来越多抗腐蚀微生物的发现,以及有益菌膜研究的开展,研究者们发现了微生物抑制金属腐蚀的众多机理,本文对此进行了归纳总结。微生物可以通过生物驱除、分泌腐蚀抑制剂、生成胞外多聚物、降低溶解氧、形成生物膜屏障、分泌生物表面活性剂、噬菌体控制、非生物膜屏障等过程控制和减缓金属腐蚀。金属的微生物腐蚀抑制作用通常不是由单一机制引起的,而是多种机制共同作用的结果。深入理解微生物抑制金属腐蚀的机理,有利于为减缓金属腐蚀行为提供借鉴。 | 田园 裴学政 朱晓丽 Jose Alberto Alvarado Garcia 李佳星 赵晨阳 梁丽华 | 2020 | 微生物学通报2020，47，12： | 2 |
| 13 | Decline of sacred fir (Abies religiosa) in a forest park south of Mexico City显示文摘 | Alvarado R de Bauer L I Galindo A J | 1993 | Environmental Pollution1993，80，： | 2 |
| 14 | Insights into the Tricholomatineae (Agaricales, Agaricomycetes): a new arrangement of Biannulariaceae and Callistosporium, Callistosporiaceae fam. nov., Xerophorus stat. nov., and Pleurocollybia incorporated into Callistosporium显示文摘A new classification of the taxa formerly ascribed to Biannulariaceae(≡Catathelasmataceae),viz.Catathelasma(type),Callistosporium,Pleurocollybia,Macrocybe,Pseudolaccaria,Guyanagarika and Anupama is here proposed.Phylogenetic inference of the Tricholomatineae based on the analysis of a combined dataset of nuclear genes including ITS,18S and 28S rDNA,tef1 and rpb2 data supports significantly a monophyletic origin of the aforementioned genera with the exception of Catathelasma,which is significantly related with Bonomyces and Cleistocybe.Biannulariaceae is therefore emended to include the clade formed by Catathelasma,Bonomyces and Cleistocybe.Consequently,the new family Callistosporiaceae is proposed to name the clade containing Callistosporium(=Pleurocollybia)and related genera.Species of Callistosporium with distant lamellae,long hygrophoroid basidia and large amygdaliform spores are accommodated in the new genus Xero-phorus.Finally,the new species Callistosporium pseudofelleum and Macrocybe sardoa are described,Clitocybe hesleri and C.fellea are combined into Callistosporium and Pseudolaccaria,respectively,and Callistosporium olivascens var.donadinii is upgraded to species rank and combined into Xerophorus. | Alfredo Vizzini Giovanni Consiglio Mauro Marchetti Pablo Alvarado | 2020 | Fungal Diversity2020，，2： | 2 |
| 15 | Pseudoclitocybaceae fam. nov. (Agaricales, Tricholomatineae), a new arrangement at family, genus and species level显示文摘A new classification of several clitocyboid taxa is here proposed to accommodate results from multigenic phylogenetic inference.The analysis of ITS rDNA as well as a combined dataset including 18S and 28S rDNA,tef1 and rpb2 data,support significantly a shared monophyletic origin of the genera Pseudoclitocybe,Musumecia and Pogonoloma,and the species Clitocybe alexandri and C.harperi.The new family Pseudoclitocybaceae is here proposed to name this clade,characterized by the presence of loop-like clamp connections in most species,absence of cystidia,and parallel hymenophoral trama with broad,cylindrical hyphae with intracellular granulations.The new genera Clitopaxillus and Harmajaea are proposed to accommodate the type species C.alexandri and H.harperi,as well as the combination H.wellsiae.In addition,two new species are described:C.fibulatus has a differential distribution of clamp connections in the basidiome,while H.guldeniae is,by now,an exclusively European taxon with brownish pileus,somewhat decurrent gills,ovoid spores and basidia longer than those of H.harperi.Finally,the species concept within Pseudoclitocybe and Pogonoloma is discussed and descriptions of the most representative species are provided. | Pablo Alvarado Pierre-Arthur Moreau Balint Dima Alfredo Vizzini Giovanni Consiglio Gabriel Moreno Ledo Setti Tapio Kekki Seppo Huhtinen Kare Liimatainen Tuula Niskanen | 2018 | Fungal Diversity2018，，3： | 2 |
| 16 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 17 | Integration Level for the Association of Southeast Asian Nations (ASEAN) Economic Community显示文摘 | Sylvia Cristina Alvarado Navas | 2016 | Chinese Business Review2016，15，2： | 2 |
| 18 | The Stability of Power System Markets显示文摘 | Alvarado F L | 1999 | IEEE Trans on PAS1999，14，2： | 1 |
| 19 | Beta catenin is associated with breast cancer progression in vitro显示文摘 | Calaf GM Alvarado ME Hei TK | 2005 | Int J Oncol2005，26，4： | 1 |
| 20 | Point of Collapse and Continuation Methods for Large AC/DC Systems 显示文摘 | Canizares C A Alvarado F L | 1993 | IEEE Trans on Power Systems1993，8，1： | 1 |
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