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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | Perianal Crohn's disease: Is there something new?显示文摘Perianal lesions are common in patients with Crohn's disease, and display aggressive behavior in some cases. An accurate diagnosis is necessary for the optimal management of perianal lesions. Treatment of perianal Crohn's disease includes medical and/or surgical options. Recent discoveries in the pathogenesis of this disease have led to advances in medical and surgical therapy with good results. Perianal lesions in Crohn's disease remain a challenging aspect for both gastroenterologists and surgeons and lead to a greatly impaired quality of life for all patients affected by this disease. A multidisciplinary approach is mandatory to obtain the best results. | Cesare Ruffolo Marilisa Citton Marco Scarpa Imerio Angriman Marco Massani Ezio Caratozzolo Nicolò Bassi | 2011 | World Journal of Gastroenterology2011，17，15： | 3 |
| 3 | PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis显示文摘 | Kathrin Ludwig Matteo Fassan Claudia Mescoli Marco Pizzi Mariangela Balistreri Laura Albertoni Salvatore Pucciarelli Marco Scarpa Giacomo Carlo Sturniolo Imerio Angriman Massimo Rugge | 2013 | Virchows Archiv2013，，1： | 3 |
| 4 | B1a lymphocytes in the rectal mucosa of ulcerative colitis patients显示文摘AIM:To assess B1a cell expression in the rectal mucosa of ulcerative colitis (UC) patients in comparison with healthy controls.METHODS:Rectal mucosa biopsies were collected from 15 UC patients and 17 healthy controls.CD5 + B cells were analysed by three colour flow cytometry from rectal mucosal samples after mechanical disaggregation by Medimachine.Immunohistochemical analysis of B and T lymphocytes was also performed.Correlations between,on the one hand,rectal B1a cell concentrations and,on the other,erythrocyte sedimentation rate and C-reactive protein levels and clinical,endoscopic and histological disease activity indices were evaluated.RESULTS:Rectal B-lymphocyte (CD19 + /CD45 +) rate and concentration were higher in UC patients compared with those in healthy controls (47.85% ± 3.12% vs 26.10% ± 3.40%,P=0.001 and 501 ± 91 cells/mm 2 vs 117 ± 18 cells/mm 2,P < 0.001);Rectal B1a cell density (CD5 + CD19 +) was higher in UC patients than in healthy controls (85 ± 15 cells/mm 2 vs 31 ± 6.7 cells/mm 2,P=0.009).Rectal B1a cell (CD5/CD19 +) rate correlated inversely with endoscopic classification (Rs=-0.637,P < 0.05).CONCLUSION:B1a lymphocytes seem to be involved in the pathogenesis of UC,however,the role they play in its early phases and in disease activity,have yet to be defined. | Lino Polese Riccardo Boetto Giuseppe De Franchis Imerio Angriman Andrea Porzionato Lorenzo Norberto Giacomo Carlo Sturniolo Veronica Macchi Raffaele De Caro Stefano Merigliano | 2012 | World Journal of Gastroenterology2012，18，2： | 2 |
| 5 | Relevance of fecal calprotectin and lactoferrin in the postoperative management of inflammatory bowel diseases显示文摘The role of fecal lactoferrin and calprotectin has been extensively studied in many areas of inflammatory bowel disease(IBD) patients' management. The postoperative setting in both Crohn's disease(CD) and ulcerative colitis(UC) patients has been less investigated although few promising results come from small, crosssectional studies. Therefore, the current post-operative management still requires endoscopy 6-12 mo after intestinal resection for CD in order to exclude endoscopic recurrence and plan the therapeutic strategy. In patients who underwent restorative proctocolectomy, endoscopy is required whenever symptoms includes the possibility of pouchitis. There is emerging evidence that fecal calprotectin and lactoferrin are useful surrogate markers of inflammation in the post-operative setting, they correlate with the presence and severity of endoscopic recurrence according to Rutgeerts' score and possibly predict the subsequent clinical recurrence and response to therapy in CD patients. Similarly, fecal markers show a good correlation with the presence of pouchitis, as confirmed by endoscopy in operated UC patients. Fecal calprotectin seems to be able to predict the short-term development of pouchitis in asymptomatic patients and to vary according to response to medical treatment. The possibility of both fecal markers to used in the routine clinical practice for monitoring IBD patients in the postoperative setting should be confirmed in multicentric clinical trial with large sample set. An algorithm that can predict the optimal use and timing of fecal markers testing, the effective need and timing of endoscopy and the cost-effectiveness of these as a strategy of care would be of great interest. | Roberta Caccaro Imerio Angriman Renata D'Incà | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 2 |
| 6 | Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis显示文摘AIM: To focus on the role of CD40 and CD40L in their pathogenesis.METHODS: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls.RESULTS: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.CONCLUSION: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations. | Lino Polese Imerio Angriman Giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa Cesare Ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 7 | High-Energy Laser Therapy of Barrett’s Esophagus: Preliminary Results显示文摘 | Lorenzo Norberto M.D. Lino Polese M.D. Imerio Angriman M.D. Francesca Erroi M.D. Attilio Cecchetto M.D. Davide F. D’Amico M.D | 2004 | World Journal of Surgery2004，，4： | 1 |
| 8 | European evidence based consensus on surgery for ulcerative colitis显示文摘 | Tom ?resland Willem Bemelman Gianluca Sampietro Antonino Spinelli Alastair Windsor Emmanuel Tiret Giuseppe Sica Yves Panis Arne Faerden Livia Biancone Imerio Angriman Zuzana Serclova Anthony De Buck Paolo Gionchetti Laurents Stassen Janindra Warusavitarne | 2014 | Journal of Crohn’s and Colitis2014，，： | 1 |
| 9 | Innate Immune Environment in Ileal Pouch Mucosa: α5 Defensin Up-regulation as Predictor of Chronic/Relapsing Pouchitis显示文摘 | Marco Scarpa Alessia Grillo Melania Scarpa Paola Brun Carlo Castoro Anna Pozza Donatella Cavallo Diego Faggian Cesare Ruffolo Renata D’Incà Romeo Bardini Ignazio Castagliuolo Imerio Angriman | 2012 | Journal of Gastrointestinal Surgery2012，，1： | 1 |
| 10 | Relationship between mucosa-associated microbiota and inflammatory parameters in the ileal pouch after restorative proctocolectomy for ulcerative colitis显示文摘 | Marco Scarpa Alessia Grillo Diego Faggian Cesare Ruffolo Elisa Bonello Renata D’Incà Melania Scarpa Ignazio Castagliuolo Imerio Angriman | 2011 | Surgery2011，，1： | 1 |
| 11 | TLR2 and TLR4 Up-regulation and Colonization of the Ileal Mucosa by Clostridiaceae spp. in Chronic/Relapsing Pouchitis 1,2显示文摘 | Marco Scarpa Alessia Grillo Anna Pozza Diego Faggian Cesare Ruffolo Melania Scarpa Renata D’Incà Mario Plebani Giacomo Carlo Sturniolo Ignazio Castagliuolo Imerio Angriman | 2011 | Journal of Surgical Research2011，，2： | 1 |
| 12 | PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis显示文摘 | Kathrin Ludwig Matteo Fassan Claudia Mescoli Marco Pizzi Mariangela Balistreri Laura Albertoni Salvatore Pucciarelli Marco Scarpa Giacomo Carlo Sturniolo Imerio Angriman Massimo Rugge | 2013 | Virchows Archiv2013，，1： | 1 |
| 13 | Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis显示文摘Restorative proctocolectomy with ileal pouch-anal anastomosis(IPAA)has become the surgical treatment of choice for many patients with medically refractory ulcerative colitis(UC)and familial adenomatous polyposis(FAP).UC patients with IPAA(UC-IPAA)are,nevertheless,susceptible to inflammatory and noninflammatory sequelae such as pouchitis,which is only rarely noted in FAP patients with IPAA.Pouchitis is the most frequent long-term complication of UC-IPAA patients,with a cumulative prevalence of up to 50%.Although the aetiology of pouchitis remains unclear,accumulating evidence suggests that a dysbiosis of the pouch microbiota and an abnormal mucosal immune response are implicated in its pathogenesis.Studies using culture and molecular techniques have detected a dysbiosis of the pouch microbiota in patients with pouchitis.Risk factors,genetic associations,and serological markers suggest that interactions between the host immune response and the pouch microbiota underlie the aetiology of this idiopathic inflammatory condition.This systematic review focuses on the dysbiosis of the microbiota that inhabit the pouch in UC and FAP patients and its interaction with the mucosal immune system.A metaanalysis was not attempted due to the highly heterogeneous microbiota composition and the different detection methods used by the various studies.Although no specific bacterial species,genus,or family has as yet been identified as pathogenic,there is evidence that a dysbiosis characterized by decreased gut microbiota diversity in UC-IPAA patients may,in genetically predisposed subjects,lead to aberrant mucosal immune regulation triggering an inflammatory process. | Imerio Angriman Marco Scarpa Ignazio Castagliuolo | 2014 | World Journal of Gastroenterology2014，20，29： | 1 |
| 14 | Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals 显示文摘 | Capone Imerio Urbani Francesca Selleri Marina | 2008 | Vaccine2008，26，8： | 1 |
| 15 | Mucosal immune environment in colonic carcinogenesis: CD80 up-regulation in colonic dysplasia in ulcerative colitis显示文摘 | Marco Scarpa Marina Bortolami Attilio Cecchetto Diego Faggian Andromachi Kotsafti Cesare Ruffolo Filippo Navaglia Anna Pozza Renata D’Incà Mario Plebani Giacomo C. Sturniolo Imerio Angriman | 2010 | European Journal of Cancer2010，，4： | 1 |
| 16 | Health related quality of life after surgery for colonic diverticular disease显示文摘Diverticular disease(DD) of the colon is very common in developed countries and is ranked the fifth most important gastrointestinal disease worldwide.The management of acute diverticulitis without perforation and peritonitis is still debated.Health related quality of life(HRQL),subjectively perceived by patients,is becoming a major issue in the evaluation of any therapeutic intervention,mainly in patients with chronic disease.To date only a few published studies can be found on Medline examining HRQL in patients with DD.The aim of this study was to review the impact of surgery for DD on HRQL.All Medline articles regarding HRQL after surgery for colonic DD,particularly those comparing different surgical approaches,were reviewed.DD has a negative impact on HRQL with lower scores in bowel function and systemic symptoms.Both surgery-related complications and disease activity have a significant impact on patients' HRQL.While no signif icant differences in HRQL between different operations for DD in non-randomized studies were revealed,the only prospective double-blind randomized study that compared laparoscopic and open colectomy found that patients undergoing laparoscopic colectomy had signif icantly reduced major postoperative complication rates and subsequently had better HRQL scores.Formal assessment of HRQL could be a good instrument in the selection of appropriate patients for elective surgery as well as in the assessment of surgical outcome. | Imerio Angriman Marco Scarpa Cesare Ruffolo | 2010 | World Journal of Gastroenterology2010，16，32： | 0 |
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