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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | Relationship between neutro- phil to lymphocyte ratio and slow coronary flow 显示文摘 | Do an M Akyel A (imen T | 2015 | Clin Appl Thromb Hemost2015，2，3： | 1 |
| 3 | Methylmalonic acidemia and hyper- glycemia : An unusual association 显示文摘 | Imen M Hanene B Ichraf K | 2012 | Brain Dev2012，34，2： | 1 |
| 4 | A technique for purifying wastewater with polymeric fiocculant produced fiom wasteplastic显示文摘 | Imene B A Bayoudh S Baklouti M | 2007 | Desalination2007，204，13： | 1 |
| 5 | Treatment of reconstituted textile wastewater containing a reactive dye in an aerobic sequencing batch reactor using a novel bacterial consortium显示文摘 | Imen K Beno M Raja B A | 2012 | Separation and Purification Technology2012，87，： | 1 |
| 6 | Breast Cancer Association with CYP1A2 Activity and Gene Polymorphisms-a Preliminary Case- control Study in Tunisia显示文摘 | Imene A Maurice A J Arij M | 2015 | Asian Pac J Cancer2015，16，8： | 1 |
| 7 | Potato peel as feed- stock for bioethanol production: A comparison of acidic and enzymatic hydrolysis 显示文摘 | Khawla B J Sameh M Imen G | 2014 | Industrial Crops and Prod- ucts2014，52，： | 1 |
| 8 | Isolation of letal DNA from nucleated erythrocytes in maternal blood 显示文摘 | Bianchi D W Flint A F Pizz imen ti M F | 1990 | Proc Nail Acad Sci USA1990，87，9： | 1 |
| 9 | Evapotranspiration modelling using support vector machines显示文摘 | KI(S)I O (C)IMEN M | 2009 | Hydrological Sciences Journal2009，54，5： | 1 |
| 10 | A new genetic algorithm for flexible job-shop scheduling problems显示文摘 | IMEN D KINZA N M ASSIA L | 2015 | Journal of mechanical science and technology2015，29，3： | 1 |
| 11 | Biosorption of cadmium ions from aqueous solution onto non-living lichen ramalina fraxirtea biomass 显示文摘 | TAY T CANDAN M ERDEM M (IMEN Y TORK H | 2009 | Clean2009，37，3： | 1 |
| 12 | Combined surgical-orthodontic rehabilitation of cleidocranial dysplasia: 5 years follow-up显示文摘Cleidocranial dysplasia(CD) is an autosomal dominant syndrome which is characterized by several skeletal malformations such as non-closed fontanelles, skeletal abnormalities of the maxilla and mandible and absence of clavicles. Mid-facial hypoplasia and mandibular prognathism are mostly seen jaw abnormalities in CD. In this study, the combined orthodontic-surgical treatment of a patient with CD with class Ⅲ malocclusion and multiple unerupted primary and deciduous teeth is presented. | Emre?imen ?mür Dereci Ay?egül Mine Tüzüner-?ncül Duygu Yaz?c?o?lu Erhan?zdiler Asl??enol Nejat Bora Sayan | 2015 | World Journal of Clinical Cases2015，3，8： | 1 |
| 13 | A technique for purifying wastewater with polymeric flocculant produced from waste plastic 显示文摘 | Imene B A Bayoudh S Baklouti M | 2007 | Desalination2007，204，13： | 1 |
| 14 | Antioxidant Potential of Ulva rigida Extracts: Protection of HeLa Cells Against H202 Cytotoxicity 显示文摘 | Sana M Ines B Imen H | 2013 | The Biology Bulletin2013，225，1： | 1 |
| 15 | Comparison of computational results obtained from a homogeneous cavitation model with experimental investigation of three inducers 显示文摘 | Imene M Farid B Robert R | 2006 | Journal of Fluids Engineering2006，128，11： | 1 |
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