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| 1 | Reduced hemoglobin and increased C-reactive protein are associated with upper gastrointestinal bleeding显示文摘AIM: To investigate the early upper gastrointestinal endoscopy(endoscopy) significantly reduces mortality resulting from upper gastrointestinal(GI) bleeding. METHODS: Upper GI bleeding was defined as 1a, 1b, 2a, and 2b according to the Forrest classification. The hemoglobin(Hb), and C-reactive protein(CRP) were examined at around the day of endoscopy and 3 mo prior to endoscopy. The rate of change was calculated as follows:(the result of blood examination on the day of endoscopy- the results of blood examination 3 mo prior to endoscopy)/(results of blood examination 3 mo prior to endoscopy). Receiver operating characteristic curves were created to determine threshold values. RESULTS: Seventy-nine men and 77 women were enrolled. There were 17 patients with upper GI bleeding: 12 with a gastric ulcer, 3 with a duodenal ulcer, 1 with an acute gastric mucosal lesion, and 1 with gastric cancer. The area under the curve(AUC), threshold, sensitivity, and specificity of Hb around the day of endoscopy were 0.902, 11.7 g/dL, 94.1%, and 77.1%, respectively, while those of CRP were 0.722, 0.5 mg/dL, 70.5%, and 73%, respectively. The AUC, threshold, sensitivity, and specificity of the rate of change of Hb were 0.851,-21.3%, 76.4%, and 82.6%, respectively, while those of CRP were 0.901, 100%, 100%, and 82.5%, respectively. CONCLUSION: Predictors for upper GI bleeding were Hb < 11.7 g/dL, reduction rate in the Hb > 21.3% and an increase in the CRP > 100%, 3 mo before endoscopy. | Minoru Tomizawa Fuminobu Shinozaki Rumiko Hasegawa Akira Togawa Yoshinori Shirai Noboru Ichiki Yasufumi Motoyoshi Takao Sugiyama Shigenori Yamamoto Makoto Sueishi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers显示文摘BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODS We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors.The levels of serum PG I/PG II and IgG against H.pylori were measured.According to their serological status,the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients,63(81.8%)expressed KK-LC-1.The IgG titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/H.pylori infection(+)]was as high as 93.9%high.KK-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H.pylori infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC. | Akiko Shida Takashi Fukuyama Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe Yoshihito Takahashi | 2020 | World Journal of Gastroenterology2020，26，4： | 3 |
| 3 | Early gastric cancer frequently has high expression of KKLC-1, a cancer-testis antigen显示文摘AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer. | Nobue Futawatari Takashi Fukuyama Rui Yamamura Akiko Shida Yoshihito Takahashi Yatsushi Nishi Yoshinobu Ichiki Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，46： | 3 |
| 4 | Expressionof monocyte chemoattractant protein-1 by nonenzymatically glycated albumin (Amadori adducts) in vascular smooth muscle cells显示文摘 | Ichiki T Funakoshi Y Ito K | 2000 | Bioche Biophys Res Commun2000，269，： | 2 |
| 5 | 99mTc-DISIDA Uptake in Liver Lesion and Pulmonary Metastases Shown on SPECT/CT in a Patient With Hepatocellular Carcinoma显示文摘 | Cristina Emiko Ueda Wilson André Ichiki Mariana Ferraz de Campos Mazo Ruiz Allan Oliveira Santos Elba Cristina Sá de Camargo Etchebehere | 2014 | Clinical Nuclear Medicine2014，，1： | 2 |
| 6 | Prepatation and characterization of silica-polyimide composite membranes coated on porous tubes for CO2 separation显示文摘 | Kusakabe K Ichiki K Hayashi J Macda H Morooka S | 1996 | Journal of Membrane Science1996，115，： | 1 |
| 7 | 显示文摘 | Ichiki M Zhang L Tanaka M | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 8 | TLR2-mediated sur- vival of Staphylococcus aureus in macrophages: a novel bacterial strategy against host innate immunity 显示文摘 | Watanabe I Ichiki M Shiratsuchi A | 2007 | J Immunol2007，178，8： | 1 |
| 9 | M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure : differential actions of 2 cGMP activating therapeutics显示文摘 | McKie PM Cataliotti A Ichiki T | 2014 | J Am Heart Assoe2014，3，00： | 1 |
| 10 | Purification, characterization, and genetic analysis of Cu-containing dissimilatory nitrite reductase from a denitrifying halophilic archaeon, Haloarcula marismortui显示文摘 | Ichiki H Tanaka Y Mochizuki K | 2001 | Journal of Bacteriology2001，183，14： | 1 |
| 11 | Studies on the green liber in cultured red bream fed low level and non-fish meal diets: Relationship between hepatic taurine and biliverdin levels显示文摘 | Takanobu Goto Shusaku Takagi Toshiaki Ichiki | 2001 | Fisheries Science2001，67，： | 1 |
| 12 | 显示文摘 | Ichiki M Morikawa Y Mabune Y | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 13 | Optimal region-of-interest settings for tissue characterization based on ultrasonic elasticity imaging显示文摘 | Tsuzuki K Hasegawa H Ichiki M | | 0，，04： | 1 |
| 14 | Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma显示文摘 | HIROKO ICHIKI TOMOAKI HOSHINO TAKASHI KINOSHI- TA | 2005 | Biochemical and Biophys- ical Research Communications2005，334，9： | 1 |
| 15 | Haemodynamia effects of a novel hypotensive peptide, human adrenomedullin in rats 显示文摘 | Ishiyama T Kitamura K Ichiki Y | 1993 | Eue J Pharmacol1993，241，： | 1 |
| 16 | Photovoltaic properties of lead lanthanum zirconate titanate ceramics in a layered film structure design 显示文摘 | Ichiki M Morikawa Y Nakada T | 2004 | Ceramics International2004，30，： | 1 |
| 17 | Effects on blood pressure and exploratory behaviour of mice lacking angiotensin Ⅱ type-2 receptor显示文摘 | Ichiki T Labosky PA Shiota C | 1995 | Nature1995，377，6551： | 1 |
| 18 | Nitriding of steel surface by spraying pulsed-arc plasma jet under at- mospheric pressure 显示文摘 | Ryuta Ichiki Hirokazu Nagamatsu Yuta Yasumatsu Tada- suke Iwao Shuichi Akamine Seiji Kanazawa | 2012 | Materials Letters2012，，71： | 1 |
| 19 | Effect of prostaglandin E1 on the rennin-aldosterone system in patients with diabetic nephropathy显示文摘 | Ichiki K Tanokuchi S | 1993 | J Int Med Res1993，21，3： | 1 |
| 20 | Gene transfer of stromal cell-derived factor-1alpha enhances is chemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway:next-generation chemokine therapy for therapeutic neovascularization显示文摘 | Hiasa K Ishibashi M Ohtani K Inoue S Zhao Q Kitamoto S Sata M Ichiki T Takeshita A EgashiraK | 2004 | Circulation2004，109，： | 1 |
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