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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Colorectal stenting for palliation and as a bridge to surgery:A 5-year follow-up study显示文摘AIM: To evaluate the long-term effectiveness of colonic stents in colorectal tumors causing large bowel obstruction.METHODS: We retrospectively analyzed data from 49 patients with colorectal cancer who had undergone colorectal stent placement between January 2008 and January 2013. Patients' symptoms,characteristics and clinicopathological data were obtained by reviewing medical records. The obstruction was diagnosed clinically and radiologically. Histopathological diagnosis was achieved endoscopically. Technical success rate(TSR)was defined as the ratio of patients with correctly placed SEMS upon stent deployment across the entire stricture length to total number of patients. Clinical success rate(CSR) was defined as the ratio of patients with technical success and successful maintenance of stent function before elective surgery(regardless of number of SEMS deployed) to total number of patients. The surgical success rate(SSR) of colorectal stent as a bridge to surgery was defined as the ratio of patients with successful surgical procedures. Unsuccessful surgical outcomes were defined as being due to insufficient colonic decompression. The technical,clinical,surgical success rates and complications after stenting were assessed.RESULTS: The median age of patients was 64(36 to 89). 44.9% of patients were male and 55.1% were female. Eighteen patients had the obstruction located in the rectum,15 patients in the rectosigmoid region,10 patients in the sigmoid region,and 6 patients had a tumor causing obstruction in the proximal colon. Each patient was categorized pathologically as stage 2(32.7%,16 patients) or stage 3(42.9%,21 patients) and 12 patients(24.4%) had metastatic disease. None of the patients received chemotherapy before stenting. Stenting was undertaken in 37 patients as a bridge to surgery,and in 12 patients stents were used for palliation. Median time to surgery after stenting was 30 ± 91.9 d. All surgery was completed in one single operation and thus no colostomy with stoma was needed. The median overall survival rate of patients with stage 2-3 colorectal cancer was 53.1 mo and stage 4 was 37.1 mo(P = 0.04). Metastatic colorectal patients who were treated palliatively with stents had backbone chemotherapy with oxaliplatin and/or irinotecan-based regimens plus antiangiogenic therapies,especially bevacizumab. Resolution of the obstruction and clinical improvement was achieved in all patients. The technical,clinical and surgical success rates were 95.9%,100% and 94.6%,respectively.CONCLUSION: The efficacy and safety of colonic stents was demonstrated both as a bridge to surgery and for palliative decompression. In addition,results emphasize the importance of the skills of the endoscopist in colonic stenting. | Baris Bayraktar Ibrahim Ali Ozemir Umut Kefeli Gokhan Demiral Julide Sagiro?lu Onur Bayraktar Gupse Adali Alp Ozcelik Osman Baran Tortum | 2015 | World Journal of Gastroenterology2015，21，31： | 3 |
| 3 | Effects of octreotide acetate and amniotic membrane on wound healing in experimental glaucoma surgery显示文摘 | Tamer Demir Burak Turgut Ulku Celiker Ibrahim Ozercan Fatih Ulas Nuray Akyol | 2003 | Documenta Ophthalmologica2003，，2： | 2 |
| 4 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation显示文摘 | Guleda Onkal-Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，38，23： | 1 |
| 5 | Prediction of wastewater treatment plant performance based on wavelet packet decomposition and neural networks显示文摘 | Hanbay Davut Turkoglu Ibrahim Demir Yakup | 2008 | Expert Systems with Applications2008，34，2： | 1 |
| 6 | Prognostic value of mesothelin expression in patients with triple negative and HER2-positive breast cancers显示文摘 | Ibrahim Vedat Bayoglu Betul Bolat Kucukzeybek Yuksel Kucukzeybek Umut Varol Ibrahim Yildiz Ahmet Alacacioglu Murat Akyol Lutfiye Demir Ahmet Dirican Yasar Yildiz Tarik Salman Mustafa Oktay Tarhan | 2015 | Biomedicine & Pharmacotherapy2015，，： | 1 |
| 7 | Processing of Al2O3/SiC ceramic cake preforms and their liquid Al metal infiltration显示文摘 | Necat Altinkok Adem Demir Ibrahim Ozsert | 2003 | Composites Part A2003，34，： | 1 |
| 8 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation显示文摘 | Guleda Onkal-Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，，23： | 1 |
| 9 | Effect of salt priming on germination and seedling growth at low temperatures in watermelon seeds during develop- ment显示文摘 | Ibrahim Demir | 2003 | Seed science technology2003，，31： | 1 |
| 10 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation显示文摘 | Guleda Onkal-Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，，23： | 1 |
| 11 | The effect of priming on seedling emergence of differentially matured watermelon seeds显示文摘 | Ibrahim Demir Kazim Mavi | 2004 | Scientia Horticulturae2004，，102： | 1 |
| 12 | Tumor angiogenesis in predicting the survival of patients with stage I lung cancer显示文摘 | Baris Medetoglu Mehmet Zeki Gunluoglu Adalet Demir Huseyin Melek Nur Buyukpinarbasili Neslihan Fener Seyyit Ibrahim Dincer | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 1 |
| 13 | Primula vulgaris extract induces cell cycle arrest and apoptosis in human cervix cancer cells显示文摘Primula vulgaris belongs to the genus Primula, members of which are frequently used in folk medicine.Various studies have investigated the cytotoxic effect of different Primula species, but there have been limited studies on the cytotoxic effect of P. vulgaris. The aim of this study was to investigate the cytotoxic effects, and possible mechanisms involved, of P. vulgaris flower extract on human cervical cancer(HeLa)cells. The cytotoxic effect of the extract on HeLa cells was revealed using the MTT assay. Mechanisms involved in the extract's cytotoxic effect were then investigated in terms of apoptosis, mitochondrial membrane potential, and the cell cycle, using fluorometric methods. P. vulgaris flower extract exhibited selective cytotoxic effects against HeLa cells by arresting their cell cycle at the S phase, and inducing the number of apoptotic cells compared to normal fibroblast cells by reducing mitochondrial membrane potential in a concentration-dependent manner. This is the first study to reveal the antiproliferative effect of P. vulgaris flower extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms. | Selim Demir Ibrahim Turan Rezzan Aliyazicioglu Serap Ozer Yaman Yuksel Aliyazicioglu | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 1 |
| 14 | Ascorbic Acid (Vitamin C) and Iloprost Attenuate the Lung Injury Caused by Ischemia/Reperfusion of the Lower Extremities of Rats显示文摘 | Ahmet Baltalarli MD Vefa Ozcan MD Bir Ferda MD Hulya Aybek MD Mustafa Sacar MD Gokhan Onem MD Ibrahim Goksin MD Suleyman Demir MD Teke Zafer | 2006 | Annals of Vascular Surgery2006，，1： | 1 |
| 15 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation 显示文摘 | Guleda Onkal-Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，38，： | 1 |
| 16 | Clitoris metastasis from a retroperitoneal leiomyosarcoma: A case report显示文摘Leiomyosarcoma is a rare form of cancer commonly found in the retroperitoneum, uterus, stomach, small intestine and vascular tissue. Surgery with a wide margin of resection is the most effective treatment. Nevertheless, metastasis is common and generally occurs within the first 3 years. The liver and lungs are the most common sites of metastasis in leiomyosarcoma. Other sites of metastasis include bone, spleen, soft tissues and brain. Metastatic tumours of the clitoris are extremely rare. As cited in the literature, the most common cancers that metastasize to the clitoris are breast, bladder, renal and gastric. Here, we report a case of a clitoral mass in a 64-year-old woman who received an operation for retroperitoneal leiomyosarcoma 4 years prior. Mass resection was performed. The pathological diagnosis was a leiomyosarcoma metastasis. The patient also presented with brain and lung metastases at the time of the clitoral metastasis. This is the first case of clitoral and brain metastases originating from a retroperitoneal leiomyosarcoma. | Suna Cokmert Lutfiye Demir Murat Akyol Ibrahim Vedat Bayoglu Alper Can Ilkay Tugba Unek Filiz Aka Bolat | 2014 | World Journal of Clinical Oncology2014，5，1： | 1 |
| 17 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation显示文摘 | Guleda Onkal-Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，38，23： | 1 |
| 18 | Assessment of urban air quality in Istanbul using fuzzy synthetic evaluation显示文摘 | Guleda Onkal - Engin Ibrahim Demir Halil Hiz | 2004 | Atmospheric Environment2004，，38： | 1 |
| 19 | Towards an integrated Flood Information System: Centralized data access, analysis, and visualization显示文摘 | Ibrahim Demir Witold F. Krajewski | 2013 | Environmental Modelling and Software2013，，： | 1 |
| 20 | Processing of Al2O3/SiC ceramic cake preforms and their liquid Al metal infiltration显示文摘 | Necat Altinkok Adem Demir Ibrahim Ozsert | 2003 | Composites Part A2003，34，： | 1 |
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