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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Early recanalization and plasma brain natriuretic peptide as an indicator of left ventricular function after acute myocardial infarction显示文摘 | TERUO I MASASHI S ISAO Y | 2002 | Am Heart J2002，143，： | 1 |
| 3 | Kurozu moromimatsu inhibits tumor growth of Lovo ceils in a mouse model in vivo 显示文摘 | NAOTO F SHIO J ISAO I | 2007 | Nutrition2007，23，1： | 1 |
| 4 | Sequential information processing during a mental arithmetic is reflected in the time course of event-related brain potentials显示文摘 | Yoshinobu I Isao H | 2000 | Clinical Neurophysiology2000，3，： | 1 |
| 5 | Sequential information processing during a mental arithmetic is reflected in the time course of event - relat- ed brain potentials显示文摘 | Yoshinobu I Isao H | 2000 | Clinical Neurophysiology2000，3，： | 1 |
| 6 | An Experimental Study on Bubble Rise Path after the Departure from a Nucleation Site in Vertical Upflow Boiling 显示文摘 | Tomio O Tatsuhiro I Isao K | 2005 | Exp Therm and Fluid Sci2005，29，： | 1 |
| 7 | Microscopic observation of emulsion droplet formation from a polycarbonate membrane显示文摘 | Isao K Motohiro Y Satoshi I | 2002 | Colloid Surf A2002，207，： | 1 |
| 8 | Nanoparticle based systemic gene therapy for lung cancer:molecular mechanisms and strategies to suppress nanoparticle-mediated inflammatory response显示文摘 | Began G Isao I Cynthia D | 2004 | Technol Cancer Res Treat2004，3，6： | 1 |
| 9 | Structure of Echinoside A and B,two antifungal Oligoglycosides form the sea cucumber Actinopyga echinites (Jaeger)显示文摘 | Isao K Tatsuya I Masako F | 1980 | J Chem Pharm Bull1980，28，5： | 1 |
| 10 | Sequential information processing during a mental arithmetic is reflected in the time course of event-related brain potenrials显示文摘 | Yoshinobu I Isao H | 2000 | Clin Neurophysiol2000，111，2： | 1 |
| 11 | High-performance hydrolysis of cellulose using mixed cellulase species and uhrasonication pretreatment显示文摘 | Masanao I Kohei I Isao S | 2004 | Biochemistry Engineering Journal2004，17，： | 1 |
| 12 | Early recanalization and plasma brain natriuretic peptide as an indicator of left ventricular function after acute myocardial infarction 显示文摘 | Terou I Masashi S Isao Y | 2002 | Am Heart J2002，143，： | 1 |
| 13 | Improvement in the long-term stability of screen-printed planar type solid-state Ag/AgC1 reference electrode by introducing poly (dimethylsiloxane) liquid juction 显示文摘 | ISAO S HIROYUKI K MASAYUKI I | 2011 | Electro- chimica Acta2011，58，： | 1 |
| 14 | Isolation and characterization of bacteria from soil contaminated with diesel oil and the possible use of these in autochthonous bioaugmentation显示文摘 | Akio U Yukiya I Isao Y | 2007 | World Journal of Microbiology and Biotechnology2007，23，12： | 1 |
| 15 | Early Recanalization and Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Function after AMI 显示文摘 | Teruo I Masashi S Isao Y | 2002 | Am Heart J2002，143，： | 1 |
| 16 | Hydration changes during thermosensitive association of a block copolymer consisting of LCST and UCST blocks显示文摘 | Yasushi M Hiroki M Isao I | 2002 | Macromol Rapid Commun2002，25，： | 1 |
| 17 | High-performance hydrolysis of cellulose using mixed cellulose species and uhrasonication pretreatment显示文摘 | MASANAO I KOHEI I ISAO S | 2004 | Bichem Eng J2004，17，2： | 1 |
| 18 | Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podoeytes 显示文摘 | Katsuhiko A Isao S Kazumi I | 2002 | Kidney Int2002，62，3： | 1 |
| 19 | Amultivariate analysis of risk factors for hepatocellular cacinogenesis: a prospective observation of 795 patiants with viral and alcoholic cirrhosis显示文摘 | Kenji I Satoshi S Isao K | 1993 | Hepatology1993，8，： | 1 |
| 20 | Enrichment of tri- glyceride doeosahexaenoic acid by lipase used as a hydrol-ysis medium in lecithin - based nano - scale molecular as- semblage 显示文摘 | kHIDEAKI K MASANAO I ISAO S | 2007 | Biochem Eng J2007，36，： | 1 |
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