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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 3 | Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome显示文摘AIM:To assess the feasibility of performing acoustic radiation force impulse(ARFI) elastography in patients with ascites and its predictive value for the cirrhotic or non-cirrhotic etiology of ascites.METHODS:Our study included 153 patients with ascites,mean age 58.8 ± 13.1 years.One hundred and fifteen(75.2%) patients had ascites in the context of cirrhosis,29(18.9%) had non-cirrhotic ascites(diagnosed by clinical,ultrasound,endoscopic and/or laparoscopic criteria) and in 9(5.9%) cases we could not establish the etiology of ascites.We performed 10 ARFI measurements and the median value was calculated and expressed in meters/second(m/s).Among the 29 patients with non-cirrhotic ascites were included:20 laparoscopically demonstrated peritoneal carcinomatosis with histological confirmation,7 acute pancreatitis with ascites which later resolved,and one case each of lymphatic ascites and ascites in the context of a liver abscess.In 11 of the 20 patients with peritoneal carcinomatosis,the liver structure was homogenous in the ultrasound examination and in 9 patients the ultrasound exam revealed liver metastases.RESULTS:We could not obtain valid ARFI measurements in 5 patients(3.2%).The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites:3.04 ± 0.70 vs 1.45 ± 0.59 m/s(P < 0.001).For a cut-off value of 1.8 m/s for predicting cirrhosis(and ascites in the context of cirrhosis),as obtained in a previous study,ARFI had 98.1% sensitivity,86.2% specificity,96.4% positive predictive value,92.5% negative predictive value and 95.6% accuracy for predicting cirrhotic ascites.For a cut-off value of 1.9 m/s the accuracy was 94.9% and for a 2 m/s cut-off value it was 92.8%.CONCLUSION:ARFI elastography is feasible in most patients with ascites and has a very good predictive value for the cirrhotic or non-cirrhotic etiology of ascites. | Simona Bota Ioan Sporea Roxana Sirli Alina Popescu Mirela Dǎnilǎ Mǎdǎlina Sendroiu | 2011 | World Journal of Radiology2011，3，8： | 2 |
| 4 | Numerical simulation of combined thermal and mass transport in a square lid-driven cavity 显示文摘 | Abdalla M Khalil M Ioan P | 2007 | International Journal of Thermal Sciences2007，46，7： | 1 |
| 5 | Sliding wear behavior of PTFE composites显示文摘 | Jaydeep K Ioan N Efstathios I M | 2002 | Wear2002，252，56： | 1 |
| 6 | Noninvasive detection through REMS-PCR technique of K-ras mutations in stool DNA of patients with colorectal cancer显示文摘 | Mixich F Ioans M Voinee F | | 0，，： | 1 |
| 7 | Modified SBA-15 mesoporous silica for heavy metal ions remediation显示文摘 | Mihaela M Aurora R Ioan S | 2008 | Chemosphere2008，73，9： | 1 |
| 8 | Red is a distractor for men in competition显示文摘 | Ioan S Sandulache M Avramescu S | 2007 | Evolution and Human Behavior2007，28，4： | 1 |
| 9 | Modified SBA - 15 mesoporous silica for heavy metal ions remediation显示文摘 | MIHAELA M AURORA R IOAN S | 2008 | Chemosphere2008，73，9： | 1 |
| 10 | Sliding wear behavior of PTFE composites显示文摘 | Jaydeep K Ioan N Efstathios I M | 2002 | Wear2002，252，： | 1 |
| 11 | Effects of working parameters on surface finish in ball-burnishing of hardened steels 显示文摘 | Liniu L Sorin N V Ioan M | 2005 | Precision Engneering2005，29，2： | 1 |
| 12 | Control strategy of three - phase battery energy storage systems for frequency support in microgrids and with uninterrupted supply of local loads 显示文摘 | Ioan S Corneliu M | 2014 | IEEE Transactions on Power Electronics2014，29，9： | 1 |
| 13 | A survey on gas leak detection and localization techniques显示文摘 | Palstefan M Ioan S | 2012 | Journal of Loss Prevention in the Process Industries2012，25，1： | 1 |
| 14 | Reduced spontaneous apoptosis in peripheral blood neutrophils during exacerbation of COPD显示文摘 | Pletz MW Ioans M Derox A | 2004 | Eur Respir J2004，23，4： | 1 |
| 15 | Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction显示文摘 | Bo Lagerqvist Ole Fr?bert G?ran K. Olivecrona Thórarinn Gudnason Michael Maeng Patrik Alstr?m Jonas Andersson Fredrik Calais J?rg Carlsson Olov Collste Matthias G?tberg Peter H?rdhammar Dan Ioanes Anders Kallryd Rickard Linder Anders Lundin Jacob Odensted | 2014 | The New England Journal of Medicine2014，，： | 1 |
| 16 | 显示文摘 | Pletz MW Ioans M deRoux A | 2004 | Eur Respir J2004，23，4： | 1 |
| 17 | Cobalt-free over-stoichiometric Laves phase alloys for Ni-MH batteries显示文摘 | DAN L ALEXANDRU R B ALEXANDRU S B EMIL I IOAN M ANDREAS Z LOUIS S | 2003 | J Alloys Comp2003，350，： | 1 |
| 18 | Identification of critical formula- tion variables for obtaining metoprolol tartrate mini-tablets 显示文摘 | Bodea M Ioan T Sorin L | 2010 | Farmacia2010，58，6： | 1 |
| 19 | Surface characterization of quaternized polysulfone films and biocompatibility studies显示文摘 | Ioan S Albu R M Avram E Stoica I Ioanid E G | | 0，，01： | 1 |
| 20 | Contrast Enhanced Ultrasound for the characterization of hepato-cellular carcinoma 显示文摘 | Alina M Ioan S Alina P | 2011 | Med Ultrasonogr2011，13，2： | 1 |
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