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| 1 | A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1显示文摘 | Huiming Sheng | 2008 | Cell Research2008，18，8： | 55 |
| 2 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
| 3 | Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β显示文摘Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreac-tire T cells,which are involved in autoimmune diseases.However,it is unknown whether attenuated activated healthyautologous T-cell immunization could increase anti-tumor immune responses.To this end,C57B1/6 mice were immunizedwith attenuated activated autologous T cells.The splenocytes from immunized mice showed a higher proliferative abil-ity than that from naive mice.The special phenotype analysis showed that there were more CDS+T cells and CD62L+T cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro(P<0.01).Theseresults demonstrated that this immunization may activate T cells in vivo.Furthermore,the splenocytes from immunizedmice revealed resistance to activation-induced cell death(AICD)in vitro.To further study the relative genes that areresponsible for the higher proliferation and resistance to AICD,the expression of Fas/Fas ligand(FasL)and GADD45βwas measured by real-time PCR.The results indicated that GADD45β transcription was higher in the splenocytes fromimmunized mice than that in the naive mice.In addition,the Fas expression showed a parallel higher,but FasL did notchange obviously.To investigate the biologic functions induced by immunization in vivo,a tumor model was establishedby EL-4 tumor cell inoculation in C57/B1 mice.Mice receiving autologous T-cell immunization had significantly inhibitedtumor growth in vivo(P<0.01).This study implicated that immunization with attenuated activated autologous T cellsenhances anti-tumor immune responses that participate in tumor growth inhibition. | Li Wang~(1,2,*) Fang Du~(1,2,*) Qi Cao~(1,2) Huiming Sheng~(1,2) Baihua Shen~(1,2) Yan Zhang~(1,2) Yingna Diao~(1,2) Jingwu Zhang~(1,2) Ningli Li~(1,2) ~1Shanghai diao Tong UniversiO,School of Medicine,280 Chongqing Road,Shanghai 200025,China ~2Shanghai Institute of Immunology,280 Chongqing Road,Shanghai 200025,China | 2006 | Cell Research2006，16，8： | 5 |
| 4 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 5 | Effect of ultrafine grinding on hydration and antioxidant properties of wheat bran dietary fiber显示文摘 | ZHU Kexue HUANG Sheng ZHOU Huiming | 2010 | Food Research International2010，43，4： | 1 |
| 6 | Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients显示文摘Serological tests play an essential role in monitoring and combating the COVID-19 pandemic.Recombinant spike protein(S protein),especially the S1 protein,is one of the major reagents used for serological tests.However,the high cost of S protein production and possible cross-reactivity with other human coronaviruses pose unavoidable challenges.By taking advantage of a peptide microarray with full spike protein coverage,we analyzed 2,434 sera from 858 COVID-19 patients,63 asymptomatic patients and 610 controls collected from multiple clinical centers.Based on the results,we identified several S protein-derived 12-mer peptides that have high diagnostic performance.In particular,for monitoring the IgG response,one peptide(aa 1148-1159 or S2-78)exhibited a sensitivity(95.5%,95%CI 93.7-96.9%)and specificity(96.7%,95%CI 94.8-98.0%)comparable to those of the S1 protein for the detection of both symptomatic and asymptomatic COVID-19 cases.Furthermore,the diagnostic performance of the S2-78(aa 1148-1159)IgG was successfully validated by ELISA in an independent sample cohort.A panel of four peptides,S1-93(aa 553-564),S1-97(aa 577-588),S1-101(aa 601-612)and S1-105(aa 625-636),that likely will avoid potential cross-reactivity with sera from patients infected by other coronaviruses was constructed.The peptides identified in this study may be applied independently or in combination with the S1 protein for accurate,affordable,and accessible COVID-19 diagnosis. | Yang Li Dan-yun La Qing Lei Zhao-wei Xu Feng Wang Hongyan Hou Lingyun Chen Jiaoxiang Wu Yan Ren Ming-liang Ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Yun-xiao Zheng Xue-ning Wang He-wei Jiang Hai-nan Zhang Huan Qi Shu-juan Guo Yandi Zhang Xiaosong Lin Zongjie Yao Pengfei Pang Dawei Shi Wei Wang Xiao Yang Jie Zhou Huiming Sheng Ziyong Sun Hong Shan Xionglin Fan Sheng-ce Tao | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 7 | COVID-ONE-hi:The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters显示文摘Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the“START”button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn. | Zhaowei Xu Yang Li Qing Lei Likun Huang Dan-yun Lai Shu-juan Guo He-wei Jiang Hongyan Hou Yun-xiao Zheng Xue-ning Wang Jiaoxiang Wu Ming-liang Ma Bo Zhang Hong Chen Caizheng Yu Jun-biao Xue Hai-nan Zhang Huan Qi Siqi Yu Mingxi Lin Yandi Zhang Xiaosong Lin Zongjie Yao Huiming Sheng Ziyong Sun Feng Wang Xionglin Fan Sheng-ce Tao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 0 |
| 8 | Research and Application of Wear Resistant Refractories for Cooling Zone of Large Scale Coke Dry Quenching Ovens显示文摘In order to prolong the service life of the cooling zone of large scale coke dry quenching ovens,six kinds possible refractories for the cooling zone of large scale coke dry quenching ovens: SiC containing brick A,SiC containing brick B,mullite-andalusite brick,spinel containing brick,zirconia containing brick,corundum-mullite brick and grade B mullite brick,were analyzed in properties. It is found that the cooling zone lining adopting SiC containing bricks or mullite-andalusite bricks has much longer service life. Based on this,a new type of wear resistant brick was developed. The brick has a compressive strength of 135 MPa,a wear loss of 2. 10cm^3(only a quarter of that of the grade B mullite brick),and a higher bulk density than the grade B mullite brick. The application of the brick in a 140t·h^(-1)coke dry quenching oven showed that it performed better than the grade B mullite brick. The cooling zone adopting the new bricks has a lower coke discharging temperature,which is beneficial to the enhancement of heat recovery efficiency and steam power generation. | XU Guotao SHENG Junbo LYU Yongjin CHEN Shengchun CUI Huiming ZHANG Honglei LIU Li | 2017 | China's Refractories2017，26，2： | 0 |
| 9 | Bound vortex light in an emulated topological defect in photonic lattices显示文摘Topology have prevailed in a variety of branches of physics.And topological defects in cosmology are speculated akin to dislocation or disclination in solids or liquid crystals.With the development of classical and quantum simulation,such speculative topological defects are well-emulated in a variety of condensed matter systems.Especially,the underlying theoretical foundations can be extensively applied to realize novel optical applications.Here,with the aid of transformation optics,we experimentally demonstrated bound vortex light on optical chips by simulating gauge fields of topological linear defects in cosmology through position-dependent coupling coefficients in a deformed photonic graphene.Furthermore,these types of photonic lattices inspired by topological linear defects can simultaneously generate and transport optical vortices,and even can control the orbital angular momentum of photons on integrated optical chips. | CHONG SHENG YAO WANG YIJUN CHANG HUIMING WANG YONGHENG LU YINGYUE YANG SHINING ZHU XIANMIN JIN HUI LIU | 2022 | Light(Science & Applications)2022，11，9： | 0 |
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