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您的检索式：作者名="Lingmin Liang"
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| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Microwave ablation in solitary hepatocellular carcinoma within 3-5 cm requiring consideration显示文摘Hepatocellular carcinoma(HCC)is a global health issue and remains the second most common cause of cancer-related deaths(1).With in-depth research in this field,treatment options are becoming more diverse.Liver resection,thermal ablation,and transplantation could offer a curative chance in early HCC.Locoregional ablation therapy,including radiofrequency ablation(RFA),microwave ablation(MWA),etc.,is a proven cure tactic for early-stage HCC.Meanwhile,MWA may provide superior tumor control over RFA and other ablations for patients with perivascular HCC(2). | Lingmin Jiang Chen Liang Feihu Xie Yun Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 3 | Fault-controlled regional magmatism and mineral deposition in central Cathaysia——Evidence from ambient noise tomography显示文摘Guangdong Province in the central Cathaysian Block has two world-class metallogenic belts, namely, the Nanling and Southeastern Coastal Metallogenic Belts(NLMB and SCMB), which are spatially coincide with the major regional Ganjiang and Zhenghe-Dapu Fault Zones(GJFZ and ZDFZ). However, what roles the faults played in mineral deposition and magmatism is unclear. Using ambient noise tomography, we obtain a 3-D whole-crust shear wave velocity model. By combining available regional geophysical models, we characterize the architecture of the regional shallow lithosphere and infer its possible tectonic connection to magmatic sources, pathways and surface deposition. The results show that the study area is loosely divided by the two major faults, the GJFZ and ZDFZ, into distinct velocity domains. In the north high Vand low V/Vcrust in the NLMB imply crustal remelting, which leads to the general felsic composition. In the coastal area, the lower crustal high Vanomaly is attributed to upwelling melts associated with Cretaceous magmatic activity. Between mineral belts, a swath of crustal lowvelocity zones extend into the uppermost mantle, manifesting partial melting related to upwelling magmas that may hint at a deep origin of magma from subcrustal lithosphere and likely feed surface mineral deposits through major faults. Secondary NW-trending faults coincide with low velocities and facilitated magmatic migration. A correlation between coastward extension of low velocities and younging of the Jurassic and Cretaceous magmatism is suggestive of a combined effect of slab rollback and a change in the direction of the Paleo-Pacific subduction system. We speculate a regional fault-control model in the central Cathaysian Block for the spatial-temporal evolution of regional deformation and magmatism during the middle Mesozoic. | Lingmin CAO Huaiyu YUAN Liang ZHAO Minghui ZHAO Haibo HUANG Tianyao HAO Xuelin QIU | 2022 | Science China Earth Sciences2022，65，9： | 0 |
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