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| 1 | Reaction environment self-modification on low-coordination Ni^(2+)octahedra atomic interface for superior electrocatalytic overall water splitting显示文摘Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively. | Kaian Sun Lei Zhao Lingyou Zeng Shoujie Liu Houyu Zhu Yanpeng Li Zheng Chen Zewen Zhuang Zhaoling Li Zhi Liu Dongwei Cao Jinchong Zhao Yunqi Liu Yuan Pan Chen Chen | 2020 | Nano Research2020，13，11： | 12 |
| 2 | Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency显示文摘基于唯一的优点荧光灯硅 nanoparticles (SiNPs ) ,长发行量红血房间(RBC ) ,和反癌症药分子(即, doxorubicin (纪录影片)) ,我们开发了使妊娠进 RBC 的多功能的装载纪录影片的 SiNPs。重要地,产生的药交货系统(DDS ) 同时展出了结合的明亮的荧光柔韧的 photostability (即, 24% 损失荧光灯在 25 min 以后的紧张连续激光照耀) 并且显著地变长的血住处(即, t 1/2= 7.31 吗?? | Airui Jiang Bin Song Xiaoyuan Ji Fei Peng Houyu Wang Yuanyuan Su Yao He | 2018 | Nano Research2018，11，4： | 6 |
| 3 | Targeted bottom-up synthesis of 1T-phase MoS2 arrays with high electrocatalytic hydrogen evolution activity by simultaneous structure and morphology engineering显示文摘 | Kaian Sun Yunqi Liu Yuan Pan Houyu Zhu Jinchong Zhao Lingyou Zeng Zhi Liu Chenguang Liu | 2018 | Nano Research2018，11，8： | 4 |
| 4 | A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82显示文摘Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including tumorigenesis.In contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged behind.Here,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients.Then,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients.We also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC progression.Results:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC progression.CircGNG7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 cells.Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients.Consistent with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor growth.Mechanistically,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic signaling.Downregulation of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor progression.Conclusions:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. | Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo Guoxin Ren | 2021 | Cancer Communications2021，41，11： | 4 |
| 5 | Unified properties of a weakly interacting Fermi gas in a weak magnetic field显示文摘When the orbital motion and the spin motion of particles were considered simultaneously,the thermodynamic potential function of a weakly interacting Fermi gas in a weak magnetic field was derived using the thermodynamics method. Based on the derived expression,the analytical expressions of energy,heat capacity,chemical potential,susceptibility and stability conditions of the system were given,and the effects of the interparticle interactions as well as the magnetic field on the properties of the system were analyzed. It was shown that the magnetic field always causes energy and stability to decrease,while the chemical potential of the system to increase. The repulsive(attractive) interactions always increase(decrease) energy and stability,but decrease(increase) the chemical potential and paramagnetism. The repulsive(attractive) interactions decrease(increase) heat capacity of the system at high temperatures but increase(decrease) it at low temperatures. | MEN FuDian LIU Hui ZHU HouYu | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 4 |
| 6 | Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles显示文摘The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and sensing.Here we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon surface.Instead of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation sites.By controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)<21%),clean surface,and homogenous elemental compositions among particles(standard deviation(SD)of weight ratios<3.5%).This approach provides a facile,green and scalable method toward the synthesis of diverse bimetallic NPs with excellent activity. | Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He | 2022 | Nano Research2022，15，1： | 2 |
| 7 | The Effect of Saturation History,Confined Pressure and Wettability on the Saturation Exponent 显示文摘 | Zhao Wenjie Li Houyu | | Transactions of '' 96 International Symposium on Well Logging Techniques for Oilfiled Development under Waterflooding0，，： | 2 |
| 8 | Highly fluorescent,photostable,and biocompatible silicon theranostic nanoprobes against Staphylococcus aureus infections显示文摘Human health is severely threatened by bacterial infections,which fuel urgent demand for the development of novel theranostic agents that are suitable for diagnosing and combating bacterial infections.To meet this goal,we synthesized a new kind of theranostic probes,made of vancomycin (Van)-modified fluorescent silicon nanoparticles (SiNPs-Van).The new probes feature good selectivity for Gram-positive bacterial infections,favorable fluorescence,strong resistance to photobleaching (e.g.,12%loss of fluorescence intensity during 40min continuous laser excitation in the presence of Staphylococcus aureus (S.aureus)),and good biocompatibility (e.g.,cell viability >95%during 24h treatment).Because of these benefits,the probes were effective at prolonged (i.e.,8-day)fluorescence tracking of S.aureus infections in vivo,thus providing a visible and accurate way to evaluate treatment efficacy.Moreover,the resultant SiNPs-Van with a minimum inhibitory concentration (MIC)of ca.0.5μg/mL exhibited high antibacterial efficiency of 92.5%,superior to that (76.5%)of free Van with higher MIC of ca.1μg/mL. | Xia Zhai Bin Song Binbin Chu Yuanyuan Su Houyu Wang Yao He | 2018 | Nano Research2018，11，12： | 2 |
| 9 | Microwave-assisted continuous flow phytosynthesis of silver nanoparticle/reduced graphene oxide composites and related visible light catalytic performance显示文摘The creation of an environmentally friendly synthesis method for silver nanomaterials(Ag-NPs)is an urgent concern for sustainable nanotechnology development.In the present study,a novel straightforward and green method for the preparation of silver nanoparti-cle/reduced graphene oxide(AgNP/rGO)composites was successfully developed through the combination of phytosynthesis,continuous flow synthesis and microwave-assistance.Oriental persimmon(Diospyros kaki Thunb.)extracts were used as both plant reducing and capping agents for fast online synthesis of AgNP/rGO composites.The experimental param-eters were optimized and the morphologies of the prepared materials were investigated.The characterization results reveal that spherical AgNPs were quickly synthesized and uni-formly dispersed on rGO sheets using the proposed online system.Fourier transform in-frared spectroscopy analysis confirmed that phenols,flavonoids,and other substances in the plant extracts played a decisive role in the synthesis of AgNP/rGO composites.Using sodium borohydride(NaBH4)degradation of p-nitrophenol(4-NP)as a model,the catalytic activity of the prepared AgNP/rGO materials was evaluated.The complete degradation of 4-NP was achieved within 12 min through the use of AgNP/rGO materials,and the compos-ite had a much better catalytic activity than the bare AgNPs and rGO had.Compared with the conventional chemical method,our online method is facile,fast,cost-efficient,and en-vironmentally friendly. | Houyu Wang Chun-Gang Yuan Chenchen Liu Xuelei Duan Qi Guo Yiwen Shen Jingfu Liu Yongsheng Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 10 | Electroluminescence from triplet metal—ligand charge-transfer excited state of transition metal complexes显示文摘 | Yuguang Ma Houyu Zhang Jiacong Shen Chiming Che | 1998 | Synthetic Metals1998，，3： | 2 |
| 11 | Constitutive model models in stability analysis of rock slope 显示文摘 | Yan Zhixin Duan Jian Wang Houyu | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 12 | Prognostic significance of Survivin and CD44v6 in laryngeal cancer surgical margins显示文摘 | Houyu Zhao Jie Ren Xianlu Zhuo | 2008 | J Cancer Res Clin Oncol2008，134，10： | 1 |
| 13 | Constitutive models in stabili- ty analysis of rock slope显示文摘 | Yan Zhixin Duan Jian Wang Houyu | 2008 | Journal of Central South University of Technology2008，15，2： | 1 |
| 14 | Thermal stability conditions of a weakly interacting Fermi gas in a weak magnetic field显示文摘On the basis of the results derived from pseudopotential method and ensemble theory,thermal stability of a weakly interacting Fermi gas in a weak magnetic field is studied by using analytical method of thermodynamics.The exact analytical expressions of stability conditions at different temperatures are given,and the effects of interactions as well as magnetic field on the stability of the system are discussed.It is shown that there is an upperlimit magnetic field for the stability of the system at low temperatures,and there is an attractive dividing value at high temperatures.If attractive interaction is lower than the critical value,the stability of the system has no request for magnetic field,but if attractive interaction is higher than the dividing value,a lower-limit magnetic field exists for the stability of the system. | Fudian Men Hui Liu Houyu Zhu | 2009 | Progress in Natural Science:Materials International2009，19，1： | 1 |
| 15 | Electroluminescence from triplet metal—ligand charge-transfer excited state of transition metal complexes显示文摘 | Yuguang Ma Houyu Zhang Jiacong Shen Chiming Che | 1998 | Synthetic Metals1998，，3： | 1 |
| 16 | Purification and characterization of chicken erythrocyte histone deacetylase I 显示文摘 | Sun Jianming Chen Houyu Moniwa M | 1999 | Biochemistry1999，38，18： | 1 |
| 17 | Ten years en-doscopy analysis显示文摘 | Chen ShiYao wu with method Liu HouYu | 2012 | World gastroenterology2012，7，1： | 1 |
| 18 | Candidate therapeutic agents in a newly established triple wild-typemucosalmelanoma cell line显示文摘Background:Mucosalmelanoma has characteristically distinct genetic features and typically poor prognosis.The lack of representativemucosal melanoma models,especially cell lines,has hindered translational research on this melanoma subtype.In this study,we aimed to establish and provide the biological properties,genomic features and the pharmacological profiles of a mucosal melanoma cell line that would contribute to the understanding and treatment optimization of molecularly-defined mucosal melanoma subtype.Methods:The sample was collected from a 67-year-old mucosal melanoma patient and processed into pieces for the establishment of cell line and patientderived xenograft(PDX)model.The proliferation and tumorigenic property of cancer cells from different passageswere evaluated,andwhole-genome sequencing(WGS)was performed on the original tumor,PDX,established cell line,and the matched blood to confirm the establishment and define the genomic features of this cell line.AmpliconArchitect was conducted to depict the architecture of amplified regions detected by WGS.High-throughput drug screening(HTDS)assay including a total of 103 therapeutic agents was implemented on the established cell line,and selected candidate agents were validated in the corresponding PDX model.Results:A mucosal melanoma cell line,MM9H-1,was established which exhibited robust proliferation and tumorigenicity after more than 100 serial passages.Genomic analysis of MM9H-1,corresponding PDX,and the original tumor showed genetic fidelity across genomes,and MM9H-1 was defined as a triple wild-type(TWT)melanoma subtype lacking well-characterized“driver mutations”.Instead,the amplification of several oncogenes,telomerase reverse transcriptase(TERT),v-Rafmurine sarcoma viral oncogene homolog B1(BRAF),melanocyte Inducing transcription factor(MITF)and INO80 complex ATPase subunit(INO80),via large-scale genomic rearrangement potentially contributed to oncogenesis of MM9H-1.Moreover,HTDS identified proteasome inhibitors,especially bortezomib,as promising therapeutic candidates for MM9H-1,which was verified in the corresponding PDX model in vivo.Conclusions:We established and characterized a new mucosal melanoma cell line,MM9H-1,and defined this cell line as a TWT melanoma subtype lacking well-characterized“driver mutations”.The MM9H-1 cell line could be adopted as a unique model for the preclinical investigation of mucosal melanoma. | Chaoji Shi Ziyue Gu Shengming Xu Houyu Ju Yunteng Wu Yong Han Jiayi Li Chuwen Li Jing Wu Lizhen Wang Jiang Li Guoyu Zhou Weimin Ye Guoxin Ren Zhiyuan Zhang Rong Zhou | 2022 | Cancer Communications2022，42，7： | 1 |
| 19 | Silicon-based nanoprobes cross the blood–brain barrier for photothermal therapy of glioblastoma显示文摘Traditional photothermal agents of indocyanine green(ICG)have poor stability,short circulation time,and poor brain permeability due to the blood–brain barrier(BBB),greatly impairing their therapeutic efficacy in glioblastoma(GBM).Herein,we develop a novel kind of SiNPs-based nanoprobes to bypass the BBB for photothermal therapy of GBM.Typically,the SiNPs-based nanoprobes are composed of the particle itself,the BBB-targeting ligand of glucosamine(G),and the therapeutic agent of ICG.We demonstrate that the as-synthesized nanoprobes could cross the BBB through glucose transporter-1(GLUT1)-mediated transcytosis,followed by accumulation at GBM tissues in mice.Compared with free ICG,G-ICG-SiNPs show stronger stability(for example,the fluorescence intensity of G-ICG-SiNPs loaded with the same dose of ICG decays by 34.6%after 25 days of storage,while the fluorescence intensity of ICG decays by 99.5%under the same conditions).Furthermore,the blood circulation time of G-ICG-SiNPs increases by about 17.3-fold compared with their ICG counterparts.After injection of the therapeutic agents into the GBM-bearing mice,GBM-surface temperature rises to 45.3℃in G-ICG-SiNPs group after 5-min 808 nm irradiation but climbs only to 36.1℃in equivalent ICG group under the identical conditions,indicating the superior photothermal effects of GICG-SiNPs in vivo. | Rong Sun Mingzhu Liu Zhaojian Xu Bin Song Yao He Houyu Wang | 2022 | Nano Research2022，15，8： | 0 |
| 20 | Spatial distribution of bacterial resistance towards antibiotics of rural sanitation system in China and its potential link with diseases incidence显示文摘Chinese government is vigorously promoting toilet renovation in rural areas to reduce the risk of human feces exposure,which would cause infectious diseases,especially antibiotic resistance genes(ARGs)and pathogens.However,the distribution of ARGs in human feces from different regions of China remained ill-defined.It is not yet known how the survival of ARGs after toilet treatment is associated with the regional infection rates.Here,we investigated the prevalence of ARGs in human feces in rural areas of China and their potential relationship with infectious diseases for the first large-scale.The results showed that there were still high ARGs residues in human feces after rural toilet treatment,especially tetM-01 and ermB with average relative abundance as high as 1.21×10^(−1)(Eastern)and 1.56×10^(−1)(Northern),respectively.At a large regional scale,the significant differences in human feces resistomeswere mainly shaped by the toilet types,TN,NH_(3)-N,and the bacterial community.A critical finding was that toilets still cannot effectively decrease the pathogenicity risk in human feces.The significant positive relationship(P<0.05)between infectious diseases and ARGs can infer that ARGs in human feces exposure might be a critical path for enhancing the incidence of diseases,as these ARGs hinder the effectiveness of antibiotics. | Houyu Li Lu Tan Chunxue Zhang Xiaocheng Wei Qiang Wang Qian Li Xiangqun Zheng Yan Xu | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
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