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| 1 | Potential toxic risk of heavy metals from sediment of the Pearl River in South China显示文摘Based on the monitoring of five heavy metal elements in the surface sediments of the Pearl River in South China, potential toxicity of the heavy metals was assessed using consensus-based sediment quality guidelines (SQGs) method and geo-accumulation (Igeo) index method. The monitoring results showed the heavy metal concentrations were significantly and positively correlated with each other, demonstrating a common trend in variation of concentration in the surface sediments. The assessment using the consensus-based SQGs method showed the potential toxicity of Cu was the highest, and Cd was the lowest. The evaluation based on mean probable effect concentration (PEC) quotient showed the region was seriously polluted with high toxicity heavy metals. Correlation analysis revealed a significant and positive correlation between the mean PEC quotient and the average of Igeo with a correlation coefficient of 0.926 (n = 23, P < 0.01). In conclusion, the consensus-based SQGs and mean PEC quotient are applicable to assess potential toxicity risks of heavy metals in freshwater sediments in the Pearl River. | NIU Hongyi DENG Wenjing WU Qunhe CHEN Xingeng | 2009 | Journal of Environmental Sciences2009，21，8： | 52 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 4 | Liutex theoretical system and six core elements of vortex identification显示文摘The third-generation vortex identification method of Liutex(previously called Rortex)was introduced by the team led by Prof.Chaoqun Liu from University of Texas at Arlington to mathematically extract the rigid rotation part from the fluid motion,and thus to define and visualize vortices.Unlike the vorticity-based first generation and the scalar-valued second generation,Q,λ2,Δandλci methods for example,the Liutex vector provides a unique,mathematical and systematic way to define vortices and visualize vortical structures from multiple perspectives without ambiguity.In this article,we summarize the recent developments of the Liutex framework and discuss the Liutex theoretical system including its existence,uniqueness,stability,Galilean invariance,locality and globality,decomposition in tensor and vector forms,Liutex similarity in turbulence,and multiple Liutex-based vortex visualization methods including Liutex lines,Liutex magnitude iso-surfaces,Liutex-Ωmethod,and Liutex core line method,etc..Thereafter,the six core elements of vortex identification,including(1)absolute strength,(2)relative strength,(3)local rotational axis,(4)vortex rotation axes,(5)vortex core size,(6)vortex boundary,are used as touchstones against which the Liutex vortex identification system is examined.It is demonstrated with illustrative examples that the Liutex system is able to give complete and precise information of all six core elements in contrast to the failure and inaccuracy of the first and second-generation methods.The important concept that vorticity cannot represent vortex and the superiority of the Liutex system over previous methods are reiterated and stated in appropriate places throughout the paper.Finally,the article concludes with future perspectives,especially the application of the Liutex system in studying turbulence mechanisms encouraged by the discovery of Liutex similarity law.As a newly defined physical quantity,Liutex may open a door for quantified vortex and turbulence research including Liutex(vortex)dynamics and lead the community out of the shadow of turbulence research which traditionally relies on observations,graphics,assumptions,hypotheses,and other qualitative analyses.An optimistic projection is that the Liutex system could be critical to investigation of the vortex dynamics in applications from hydrodynamics,aerodynamics,oceanography,meteorology,etc.and to research of the generation,sustenance,modelling and controlling of turbulence. | Yi-qian Wang Yi-sheng Gao Hongyi Xu Xiang-rui Dong Jian-ming Liu Wen-qian Xu Meng-long Chen Chaoqun Liu | 2020 | Journal of Hydrodynamics2020，32，2： | 17 |
| 5 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 6 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 7 | Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body显示文摘A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of skin.In the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging techniques.Three types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein camera.Several longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by MRI.Among the visualised veins,the partial walls of a few veins were enhanced by Gd-DTPA.The fluorescent images further indicated that STPs likely represent boundless pathways.The findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies. | Hongyi Li Jiabin Tong Weiguo Cao Min Chen Hua Li Hong Dai Liang Xu Xiaoliang Chen | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 8 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 9 | Structure and quality controlled growth of InAs nanowires through catalyst engineering显示文摘在这研究,结构和用在一个分子的横梁取向附生反应堆的 Au 催化剂的 InAs nanowires 的 quality controlled 生长被介绍。由在催化剂调节铟集中,没有缺点的 wurtzite 结构和没有缺点的锌闪锌矿结构 InAs nanowires 能被导致。这些没有缺点的锌闪锌矿结构 InAs nanowires 沿着\成长,这被发现( \left\langle { \bar 1 \bar 10 } \right\rangle \)方向与四低精力{ 111 }并且二{ 110 }方面墙方面并且采用\( \left ({ \bar 1 \bar 1 \bar 1 } \right )\) catalyst/nanowire 接口。我们的结构、化学的描述和计算为 InAs nanowire 生长识别催化剂过度饱和阀值的存在。什么时候在里面在催化剂的集中足够地高,没有缺点的锌闪锌矿结构 InAs nanowires 能被导致。这研究通过催化剂工程提供卓见进晶体结构的操作和 IIIV 半导体 nanowires 的结构质量。 | ZhiZhang Zhenyu Lu Hongyi Xu Pingping Chen Wei Lu Jin Zou | 2014 | Nano Research2014，7，11： | 4 |
| 10 | Geological characteristics of the Sizhuang gold deposit in the region of Jiaodong, Shandong Province——A study on tectono-geochemical ore prospecting of ore deposits显示文摘Tectono-geochemical samples were systematically collected from 5 drillcores along the No. 304 explora-tion line and at the -310 m level under the pit in the mining area, totalling 705 samples from the metamorphic rocks, granites, altered rocks and orebodies, and were determined for their contents of 20 kinds of elements including Au, Ag, As, Sb, Hg, Cu,,Pb, Zn, Sn, Bi, Mo, Co, Ni, Mn, Cr, V, Ti, Ba, Rb, Sr, etc. By using the Surfer software the geochemical exploration line profile maps for the 20 kinds of elements and the curves for the element geochemical contents of individual ore vein groups were established. In conbination with the geochemical map analytical method and Gregorian's zoning index calculation method, the vertical, longitudinal and lateral zonation sequences of the elements were ascertained and the geochemical three-dimentional zonation model of the primary halos was estab-lished on the basis of the analysis of metallogenic structures and alteration zonation. Coupled with the results of analysis of the geology and geochemistry data, it may be concluded that the process of alteration of granites in the mining area is also accompanied with the process of gold enrichment and mineralization. With the intensification of alteration of granites from granite →potash feldspathization granite →sericite-quartz alteration granite, seric-ite-quartz rocks →beresitized granite, pyrite sericite-quartz rock, silicified granite →gold ore, the contents of thio-phile ore-forming elements such as Au, Ag, As, Cu, Bi, Mo, Pb, Sb, Hg, and Sn tended to increase. Factor analysis of trace elements indicated: factor F2 (Au, Ag, Cu, Sn, As) represents the element association brought in at the main stage of hydrothermal metallogenesis; factor F4 (Bi, Sb) and factor F5 (Pb, Zn) represent the ore-forming element association supperposed during the late stage of Au-bearing sulfides. By using the Gregorian's zoning index and map analysis method we have ascertained the primary halo axial zonation sequence (form frontal halo →tail halo): Pb, Zn, Mn, Ba, Sr, Rb, As, Sb, Ag, Cu, Sn, Mo, Au, Bi, Hg, Ti, Cr, V, Ni, and Co. The geochemical anomalies in the mining area display a tendency of lateral plunging to WS, which is consistent with the lateral plunging of orebodies and mineralization alteration zone. Comprehensive analysis of the results of investigations on ore-controlling structures, mineralization-alteration zonation and geochemical zonation of the primary halos indicates that the gold orebodies in this area are still of greater extension. | QIAN Jianping CHEN Hongyi MENG Yong | 2011 | Chinese Journal Of Geochemistry2011，30，4： | 4 |
| 11 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 12 | Key Recovery Against 3DES in CPU Smart Card Based on Improved Correlation Power Analysis显示文摘The security of CPU smart cards,which are widely used throughout China,is currently being threatened by side-channel analysis.Typical countermeasures to side-channel analysis involve adding noise and filtering the power consumption signal.In this paper,we integrate appropriate preprocessing methods with an improved attack strategy to generate a key recovery solution to the shortcomings of these countermeasures.Our proposed attack strategy improves the attack result by combining information leaked from two adjacent clock cycles.Using our laboratory-based power analysis system,we verified the proposed key recovery solution by performing a successful correlation power analysis on a Triple Data Encryption Standard(3DES)hardware module in a real-life 32-bit CPU smart card.All 112 key bits of the 3DES were recovered with about 80 000 power traces. | Yanting Ren Liji Wu Hexin Li Xiangyu Li Xiangmin Zhang An Wang Hongyi Chen | 2016 | Tsinghua Science and Technology2016，21，2： | 3 |
| 13 | A new approach to the time evolution of characteristic function of the density operator obtained by virtue of thermal entangled state representation显示文摘Like the progress made by Dirac that wave function ψ(x) was reformed as x |ψ,where x| is the coordinate representation,we endow the characteristic function χλ = Tr(e λa-λaρ) of density operator ρ with the meaning of wave function of |ρ in the thermal entangled state η| representation in the doubled Fock space,χλ = η = λ|ρ,where |ρ = ρ|η = 0.We find the time evolution of χλ can then be directly and neatly obtained via this approach.The way of deriving the density operator from η = λ | ρ is also presented. | CHEN Feng FAN HongYi | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 3 |
| 14 | Application on the'Shear-Extrusion'Process to Form Large-size High-pressure Valve Bodies显示文摘This paper describes a new metal plastic forming process named 'shear-extrusion'. The new process is studied by using numerical analysis and experiment methods, and applied to form large-size high pressure valve bodies used by power plant boiler. Finally, the valve bodies have been successfully formed on the 10000 kN screw press. | Hongyi SUN Yu CHEN Dachang KANG | 2001 | Journal of Materials Science & Technology2001，17，1： | 3 |
| 15 | Layers of interstitial fluid flow along a“slit-shaped”vascular adventitia显示文摘Interstitial fluid(ISF)flow through vascular adventitia has been discovered recently.However,its kinetic pattern was unclear.We used histological and topographical identification to observe ISF flow along venous vessels in rabbits.By magnetic resonance imaging(MRI)in live subjects,the inherent pathways of ISF flow from the ankle dermis through the legs,abdomen,and thorax were enhanced by paramagnetic contrast.By fluorescence stereomicroscopy and layer-by-layer dissection after the rabbits were sacrificed,the perivascular and adventitial connective tissues(PACTs)along the saphenous veins and inferior vena cava were found to be stained by sodium fluorescein from the ankle dermis,which coincided with the findings by MRI.The direction of ISF transport in a venous PACT pathway was the same as that of venous blood flow.By confocal microscopy and histological analysis,the stained PACT pathways were verified to be the fibrous connective tissues,consisting of longitudinally assembled fibers.Real-time observations by fluorescence stereomicroscopy revealed at least two types of spaces for ISF flow:one along adventitial fibers and another one between the vascular adventitia and its covering fascia.Using nanoparticles and surfactants,a PACT pathway was found to be accessible by a nanoparticle of<100 nm and contained two parts:a transport channel and an absorptive part.The calculated velocity of continuous ISF flow along fibers of the PACT pathway was 3.6-15.6 mm/s.These data revealed that a PACT pathway was a'slit-shaped'porous biomaterial,comprising a longitudinal transport channel and an absorptive part for imbibition.The use of surfactants suggested that interfacial tension might play an essential role in layers of continuous ISF flow along vascular vessels.A hypothetical'gel pump'is proposed based on interfacial tension and interactions to regulate ISF flow.These experimental findings may inspire future studies to explore the physiological and pathophysiological functions of vascular ISF or interfacial fluid flow among interstitial connective tissues throughout the body. | Hongyi LI You LYU Xiaoliang CHEN Bei LI Qi HUA Fusui JI Yajun YIN Hua LI | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，8： | 3 |
| 16 | Siderophile Element Compositions of Pyroxenes in HED Meteorites: Implications for the Differentiation of Magma Ocean on Vesta显示文摘1 Introduction The howardite,eucrite and diogenite(HED)meteorites are ultramafic and mafic igneous rocks and impact-engendered breccias derived from a thoroughly differentiated asteroid 4 Vesta.Diogenites include dunites, | CHEN Hongyi MIAO Bingkui XIE Lanfang SHAO Huimin | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 17 | Porous graphene paper for supercapacitor applications显示文摘Graphene paper shows a great promise for the electrical energy storage. However, the high stability, purity and specific surface area have become stringent requirements for supercapacitor applications. Finding methods to tackle these problems is rather challenging. Here, we develop a facile method to prepare porous graphene papers with a thickness 0.5 mm by a thermal shock to the layer-structure graphene paper self-assembled on Cu foil under nitrogen flowing. The as-prepared porous graphene paper exhibits a large specific capacitance of 100 F g^(-1)at the scan rate of 100 m V s^(-1)with high stability and purity without any residual chemical reagents, showing a promising potential for supercapacitor applications. The high electrochemical properties are mainly attributed to the high-specific area and the improved conductivity of the porous graphene paper performed by the multieffect of reducing, cleaving and expanding to the layer-structure graphene paper by high-energy thermal heating during the thermal shock process. This work paves a pathway to the facile preparation of porous graphene paper for supercapacitor applications. | Qi Li Xinli Guo Yao Zhang Weijie Zhang Chuang Ge Li Zhao Xiaojuan Wang Hongyi Zhang Jian Chen Zengmei Wang Litao Sun | 2017 | Journal of Materials Science & Technology2017，33，8： | 2 |
| 18 | Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects显示文摘The aim of this study was to apply the reference-scaled average bioequivalence(RSABE)approach to evaluate the bioequivalence of 2 formulations of agomelatine,and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects.This was performed in a single-dose,randomized-sequence,open-label,four-way crossover study with a one-day washout period between doses.Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation.The formulations were considered bioequivalent if 90% confidence intervals(CIs)for the log-transformed ratios and ratio of geometric means(GMR)of AUC and C_(max) of agomelatine were within the predetermined bioequivalence range based on RSABE method.Results showed that both of the90% CIs for the log-transformed ratios of AUC and C_(max) of 7-desmethyl-agomelatine and 3-hydroxyagomelatine were within the predetermined bioequivalence range.The 90% CIs for natural logtransformed ratios of C_(max) ,AUC_(0–t)and AUC_(0–∞) of agomelatine(104.42–139.86,101.33–123.83 and97.90–117.94)were within the RSABE acceptance limits,and 3-hydroxy-agomelatine(105.55–123.03,101.95–109.10 and 101.72–108.70)and 7-desmethyl-agomelatine(104.50–125.23,102.36–111.50 and101.62–110.64)were within the FDA bioequivalence definition intervals(0.80–1.25 for AUC and0.75–1.33 for C_(max)).The RSABE approach was successful in evaluating the bioequivalence of these two formulations. | Fang Tang Rui Zhou Zeneng Cheng Guoping Yang Aiqiao Chen Zhi Liu Hongyi Tan Shuang Yang Sanwang Li Lingli Mu Peng Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 2 |
| 19 | A Survey of Applications Research on Content-Centric Networking显示文摘As a named data-based clean-slate future Internet architecture,Content-Centric Networking(CCN)uses entirely different protocols and communication patterns from the host-to-host IP network.In CCN,communication is wholly driven by the data consumer.Consumers must send Interest packets with the content name and not by the host’s network address.Its nature of in-network caching,Interest packets aggregation and hop-byhop communication poses unique challenges to provision of Internet applications,where traditional IP network no long works well.This paper presents a comprehensive survey of state-of-the-art application research activities related to CCN architecture.Our main aims in this survey are(a)to identify the advantages and drawbacks of CCN architectures for application provisioning;(b)to discuss the challenges and opportunities regarding service provisioning in CCN architectures;and(c)to further encourage deeper thinking about design principles for future Internet architectures from the perspective of upper-layer applications. | Xiuquan Qiao Hongyi Wang Wei Tan Athanasios V.Vasilakos Junliang Chen MBrian Blake | 2019 | China Communications2019，16，9： | 2 |
| 20 | Near-zero-dispersion soliton and broadband modulational instability Kerr microcombs in anomalous dispersion显示文摘The developing advances of microresonator-based Ker cavity solitons have enabled versatile applications ranging from communication,signal processing to high-precision measurements.Resonator dispersion is the key factor determining the Kerr comb dynamics.Near the zero group-velocity-dispersion(GVD)regime,low-noise and broadband microcomb sources are achievable,which is crucial to the application of the Kerr soliton.When the GVD is almost vanished,higher-order dispersion can significantly affect the Kerr comb dynamics.Although many studies have investigated the Kerr comb dynamics near the zero-dispersion regime in microresonator or fiber ring system,limited by dispersion profles and dispersion perturbations,the near-zero-dispersion soliton structure pumped in the anomalous dispersion side is still elusive so far.Here,we theoretically and experimentally investigate the microcomb dynamics in fiber-based Fabry-Perot microresonator with ultra-small anomalous GVD.We obtain 2/3-octave-spaning microcombs with~10 GHz spacing,>84 THz span,and>8400 comb lines in the modulational instability(MI)state,without any external nonlinear spectral broadening.Such widely-spanned Ml combs are also able to enter the soliton state.Moreover,we report the first observation of anomalous-dispersion based near-zero-dispersion solitons,which exhibits a local repetition rate up to 8.6 THz,an individual pulse duration<100 fs,a span>32 THz and>3200 comb lines.These two distinct comb states have their own advantages.The broadband MI combs possess high conversion efficiency and wide existing range,while the near-zero-dispersion soliton exhibits relatively low phase noise and ultra-high local repetition rate.This work complements the dynamics of Kerr cavity soliton near the zero-dispersion regime,and may stimulate cross-disciplinary inspirations ranging from dispersion-controlled microresonators to broadband coherent comb devices. | Zeyu Xiao Tieying Li Minglu Cai Hongyi Zhang Yi Huang Chao Li Baicheng Yao Kan Wu Jianping Chen | 2023 | Light(Science & Applications)2023，12，2： | 2 |
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