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| 1 | In vitro and in vivo evaluations of Mg-Zn-Gd alloy membrane on guided bone regeneration for rabbit calvarial defect显示文摘To develop a biodegradable membrane with guided bone regeneration(GBR),a Mg-2.0Zn-1.0Gd alloy(wt.%,MZG)membrane with Ca-P coating was designed and fabricated in this study.The microstructure,hydrophilicity,in vitro degradation,cytotoxicity,antibacterial effect and in vivo regenerative performance for the membrane with and without Ca-P coating were evaluated.After coating,the membrane exhibited an enhance hydrophilicity and corrosion resistance,showed good in vitro cytocompatibility upon MC3T3E-1 cells,and exhibited excellent antibacterial effect against E.coli,Staphylococcus epidermis and Staphylococcus aureus,simultaneously.In vivo experiment using the rabbit calvarial defect model confirmed that Ca-P coated MZG membrane underwent progressive degradation without inflammatory reaction and significantly improved the new bone formation at both 1.5 and 3 months after the surgery.All the results strongly indicate that MZG with Ca-P coating have great potential for clinical application as GBR membranes. | Jiawen Si Hongzhou Shen Hongwei Miao Yuan Tian Hua Huang Jun Shi Guangyin Yuan Guofang Shen | 2021 | Journal of Magnesium and Alloys2021，9，1： | 4 |
| 2 | Morphology analysis of tracks in the aerogels impacted by hypervelocity irregular particles显示文摘As an attractive collector medium for hypervelocity particles,combined with outstanding physical properties and suitable compositional characteristics,SiO2 aerogel has been deployed on outer space missions and laser shock-loaded collection experiments.In this paper,impact experiments were conducted to understand the penetration process of irregular grains,irregular Al_(2)O_(3) grains with two different sizes and speeds(~110μm@7 km/s,~251μm@2.3 km/s)at various density silica aerogels.By classifying the shapes of projectile residues and tracks,the morphology of tracks was analyzed.It was observed that there were several kinds of typical tracks in the penetration of irregular grains,accompanied by residues with the shapes of near-sphere,polyhedron,streamlined body wedge,and rotator.The rotational behavior was demonstrated by the final status of one flake projectile as direct evidence.In addition,there was no obvious relationship between the track length and experimental parameters,which may be caused by the uncertain interaction between aerogels and irregular particles.In addition,it confirmed the existence of fragmentation,melting situation by observing the shape of the impact entrance hole.At the same time,optical coherence tomography was used to observe the detail of tracks clearly,which provided a method to characterize the tracks nondestructively. | Ai Du Yi Ma Mingfang Liu Zhihua Zhang Guangwei Cao Hongwei Li Ling Wang Peijian Si Jun Shen Bin Zhou | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 3 | Epigallocatechin gallate reduces vascular inflammation in db/db mice possibly through an NF-KB-mediated mechanism 显示文摘 | Babu Pon V Anandh Si Hongwei Liu Dongmin | 2012 | Mol Nutr&Food Res2012，56，9： | 1 |
| 4 | Upgrading from One-way Informing to Two-way Audienceoriented Health Communication:CFSA Initiations for World Food Safety Day显示文摘Food safety is vital to the development of human society.On December 20,2018,the United Nations General Assembly adopted resolution 73/250 proclaiming a World Food Safety Day.As of 2019,every June 7 is a time to increase social awareness of food safety and to encourage actions for good health promotion.The Third World Food Safety Day on June 7,2021 aims to draw attention and inspire action to help prevent,detect,and manage foodborne risks,contributing to food security,human health,economic prosperity,agriculture,market access,tourism,and sustainable development(1).Food safety risk communication shifts from the traditional approach of one-way sender-oriented to a two-way audience-oriented communication approach. | Si Chen Juana Du Fangmin Gong Hongwei Han Jianwen Li Jinjun Liang Patrick Wall Yongning Wu Zhenyi Li | 2021 | China CDC weekly2021，3，24： | 1 |
| 5 | High corn oil dietary intake improves health and longevity of aging mice显示文摘 | Hongwei Si Longyun Zhang Siqin Liu | 2014 | Experimental Gerontology2014，58，10： | 1 |
| 6 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 7 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 8 | Mechanism and prevention method of drill string uplift during shut-in after overflow in an ultra-deep well显示文摘Drill string will sustain large uplift force during the shut-in period after gas overflow in an ultra-deep well, and in serious case, it will run out of the wellhead. A calculation model of uplift force was established to analyze dynamic change characteristics of the uplift force of drill string during the shut-in period, and then a management procedure for the uplift risk during the shut-in period after gas overflow in the ultra-deep well was formed. Cross section method and pressure area method were used to analyze the force on drill string after shut-in of well, it was found that the source of uplift force was the 'fictitious force' caused by the hydrostatic pressure in the well. When the fictitious force is in the opposite direction to the gravity, it is the uplift force. By adopting the theory of annular multiphase flow, considering the effects of wellbore afterflow and gas slippage, the dynamic change of the pressure and fluid in the wellbore and the uplift force of drill string during the shut-in period were analyzed. The magnitude and direction of uplift force are related to the length of drill string in the wellbore and shut-in time, and there is the risk of uplift of drill string when the length of drill string in the wellbore is smaller than the critical drill string length or the shut in time exceeds the critical shut in time. A set of treatment method and process to prevent the uplift of drill string is advanced during the shut-in period after overflow in the ultra-deep well, which makes the risk management of the drill string uplift in the ultra-deep well more rigorous and scientific. | YIN Hu SI Menghan LI Qian JANG Hongwei DAI Liming | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 9 | The Impact of Hyperthermotherapy plus Radiochemotherapy for Cervical Carcinoma on Long-term Survival and Toxicity显示文摘 | Hongwei Chen Yili Wang Junjie Fan Lvsheng Si Wei Luo Mingzhong Li | 2005 | Journal of US-China Medical Science2005，2，4： | 0 |
| 10 | RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis显示文摘Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)pathway.However,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains unclear.Here,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 phosphorylation.RNA-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral replication.RIPK3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I IFNs.Conversely,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV replication.RIPK3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune responses.Mechanistically,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase activity.Overall,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV. | Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，5： | 0 |
| 11 | STING strengthens host anti-hantaviral immunity through an interferon-independent pathway显示文摘Hantaan virus(HTNV),the prototype virus of hantavirus,could escape innate immunity by restraining type I interferon(IFN)responses.It is largely unknown whether there existed other efficient anti-hantaviral tactics in host cells.Here,we demonstrate that the stimulator of interferon genes(STING)strengthens the host IFNindependent anti-hantaviral immunity.HTNV infection activates RIG-I through IRE1-XBP 1-mediated ER stress,which further facilitates the subcellular translocation and activation of STING.During this process,STING triggers cellular autophagy by interacting with Rab7A,thus restricting viral replication.To note,the anti-hantaviral effects of STING are independent of canonical IFN signaling.Additionally,neither application of the pharmacological antagonist nor the agonist targeting STING could improve the outcomes of nude mice post HTNV challenge in vivo.However,the administration of plasmids exogenously expressing the mutant C-terminal tail(ΔCTT)STING,which would not trigger the type I IFN responses,protected the nude mice from lethal HTNV infection.In summary,our research revealed a novel antiviral pathway through the RIG-I-STING-autophagy pathway,which offered novel therapeutic strategies against hantavirus infection. | Kerong Wang Jian Zhang Yongheng Yang Yue Si Ziqing Zhou Xudong Zhu Sushan Wu He Liu Hui Zhang Liang Zhang Linfeng Cheng Wei Ye Xin Lv Yingfeng Lei Xijing Zhang Shilin Cheng Lixin Shen Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，4： | 0 |
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