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您的检索式：作者名="Hongwan Zhang"
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| 1 | TIGER:A Web Portal of Tumor Immunotherapy Gene Expression Resource显示文摘Immunotherapy is a promising cancer treatment method;however,only a few patients benefit from it.The development of new immunotherapy strategies and effective biomarkers of response and resistance is urgently needed.Recently,high-throughput bulk and single-cell gene expression profling technologies have generated valuable resources.However,these resources are not well organized and systematic analysis is difficult.Here,we present TIGER,a tumor immunotherapy gene expression resource,which contains bulk transcriptome data of 1508 tumor samples with clinical immunotherapy outcomes and 11,057 tumor/normal samples without clinical immunotherapy outcomes,as well as single-cell transcriptome data of 2,116,945 immune cells from 655 samples.TIGER provides many useful modules for analyzing collected and user-provided data.Using the resource in TIGER,we identified a tumor-enriched subset of CD4^(+)T cells.Patients with melanoma with a higher signature score of this subset have a significantly better response and survival under immunotherapy.We believe that TIGER will be helpful in understanding anti-tumor immunity mechanisms and discovering effective biomarkers. | Zhihang Chen Ziwei Luo Di Zhang Huiqin Li Xuefei Liu Kaiyu Zhu Hongwan Zhang Zongping Wang Penghui Zhou Jian Ren An Zhao Zhixiang Zuo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
| 2 | LncPipe" A Nextflow-based pipeline for identification and analysis of long non-coding RNAs from RNA-Seq data显示文摘Long noncoding RNAs(lncRNAs)have been increasingly implicated in a variety of human diseases,including autoimmune disease(Wu et al.,2015),neurodegenerative diseases(Wapinski and Chang,2011)and cancer(Huarte,2015).Due to recent advances in next-generation sequencing technologies,tens of thousands of lnc RNAs have been identified and annotated,a number of | Qi Zhao Yu Sun Dawei Wang Hongwan Zhang Kai Yu Jian Zheng Zhixiang Zuo | 2018 | Journal of Genetics and Genomics2018，45，7： | 0 |
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