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| 1 | Rice DENSE AND ERECT PANICLE 2 is essential for determining panicle outgrowth and elongation显示文摘包括谷物尺寸和圆锥花序形态学,圆锥花序的建筑学直接决定谷物产量。圆锥花序直立,为在中国的北部分完成理想的植物建筑学被选择,引起了米饭 breeders 的增加的注意。这里,稠密、直立的圆锥花序 2 (dep2 ) 异种,显示出稠密、直立的圆锥花序显型,被识别。没有任何已知的功能的领域, DEP2 编码植物特定的蛋白质。表示介绍 DEP2 表明它高度在年轻纸巾被表示,与在年轻圆锥花序的大多数丰富。词法并且表示分析显示在 DEP2 的那个变化主要影响脊柱和主要、第二等的分支的快速的延伸,但是不损害圆锥花序 primordia 的开始或形成。进一步的分析建议在 dep2 的圆锥花序长度的减少被一个缺点在圆锥花序的指数的延伸期间在房间增长引起。尽管有在 dep2 异种的一种更紧缩的植物类型,在谷物生产的重要改变都没在野类型和 dep2 异种之间被发现。因此, DEP2 的学习不仅加强我们圆锥花序建筑学的分子的基因基础的理解而且为米饭繁殖有重要含意。 | Feng Li Wenbo Liu Jiuyou Tang Jinfeng Chen Hongning Tong Bin Hu Chunlai Li Jun Fang Mingsheng Chen Chengcai Chu | 2010 | Cell Research2010，20，7： | 51 |
| 2 | Genome sequencing and phylogenetic analysis of Banna virus(genus Seadornavirus,family Reoviridae)isolated from Culicoides显示文摘In an investigation of blood-sucking insects and arboviruses, a virus(YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect(CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA(dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region(1.12 segments) were17,803 bp and 5,925 amino acids in length, respectively. The phylogenetic analysis of VP1 protein(RdRp) revealed that YN12243 belonged to genus Seadornavirus of family Reoviridae, and further analysis indicated that YN12243 belongs to the Banna virus(BAV) genotype A2. Additionally, YN12243 was located in the same evolutionary cluster as BAV strains isolated from different mosquito species, suggesting that the BAV isolated from Culicoides does not have species barriers. These results indicate that Culicoides can also be a vector for BAV. In view of the hematophagous habits of Culicoides on cattle, horses, deer, and other large animals, as well as the possibility of spreading and causing a variety of animal arboviral diseases, it is important to improve infection detection and monitor the BAV in large livestock. | Song Song Yuanyuan Li Shihong Fu Wenwen Lei Xiaofang Guo Yun Feng Xiaoyan Gao Xiaolong Li Zhonghua Yang Ziqian Xu Ying He Huanyu Wang Hongning Zhou Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 8 |
| 3 | Defense Against Objective Function Attacks in Cognitive Radio Networks显示文摘 | PEI Qingqi LI Hongning MA Jianfeng FAN Kefeng | 2011 | Chinese Journal of Electronics2011，20，1： | 7 |
| 4 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 5 | Neighbor Detection-Based Spectrum Sensing Algorithm in Distributed Cognitive Radio Networks显示文摘Security issues of spectrum sensing have drawn a lot of attentions in Cognitive radio networks(CRNs).Malicious users can mislead the network to make wrong decision about the states of channels by tampering spectrum sensing data.To defense against Spectrum sensing data falsification(SSDF) attack,we propose a neighbor detection-based spectrum sensing algorithm in distributed CRNs,which can detect attackers with the help of neighbors during spectrum sensing to improve the accuracy of decision making.The proposed scheme can also guarantee the connectivity of the network.Simulation results illustrate that the proposed scheme can defense against SSDF attacks effectively and reach the unified information of spectrum sensing data. | PEI Qingqi LI Hongning LIU Xianjun | 2017 | Chinese Journal of Electronics2017，26，2： | 4 |
| 6 | The U-box ubiquitin ligase TUD1 promotes brassinosteroid-induced GSK2 degradation in rice显示文摘Brassinosteroids(BRs)are a class of steroid hormones with great potential for use in crop improvement.De-repression is usually one of the key events in hormone signaling.However,how the stability of GSK2,the central negative regulator of BR signaling in rice(Oryza sativa),is regulated by BRs remains elusive.Here,we identify the U-box ubiquitin ligase TUD1 as a GSK2-interacting protein by yeast two-hybrid screening.We show that TUD1 is able to directly interact with GSK2 and ubiquitinate the protein.Phenotypes of the tud1 mutant are highly similar to those of plants with constitutively activated GSK2.Consistent with this finding,GSK2 protein accumulates in the tud1 mutant compared with the wild type.In addition,inhibition of BR synthesis promotes GSK2 accumulation and suppresses TUD1 stability.By contrast,BRs can induce GSK2 degradation but promote TUD1 accumulation.Furthermore,the GSK2 degradation process is largely impaired in tud1 in response to BR.In conclusion,our study demonstrates the role of TUD1 in BR-induced GSK2 degradation,thereby advancing our understanding of a critical step in the BR signaling pathway of rice. | Dapu Liu Xiaoxing Zhang Qingliang Li Yunhua Xiao Guoxia Zhang Wenchao Yin Mei Niu Wenjing Meng Nana Dong Jihong Liu Yanzhao Yang Qi Xie Chengcai Chu Hongning Tong | 2023 | Plant Communications2023，4，2： | 2 |
| 7 | Dynamic Cluster Key Management Scheme on Wireless Sensor Networks显示文摘Wireless sensor networks are open architectures, so any potential threat can easily intercept, wiretap and counterfeit the information. Therefore, the safety of WSN is very important. Since any single key system cannot guarantee the security of the wireless sensor network for communications, this paper introduces a hierarchical key management scheme based on the different abilities of different sensor nodes in the clustered wireless sensor network. In this scheme, the nodes are distributed into several clusters, and a cluster head must be elected for each cluster. Private communication between cluster heads is realized through the encryption system based on the identity of each head while private communication between cluster nodes in a same cluster head is achieved through the random key preliminary distribution system. Considering the characteristics of WSN, we adopt dynamic means called dynamic cluster key management scheme to deal with master key, so master key will be updated according to the changed dynamic network topology. For cluster head node plays a pivotal role in this scheme, a trust manage-ment system should be introduced into the election of the cluster head which will exclude the malicious node from outside the cluster, thus improve the whole network security. | Pei Qingqi Li Hongning Pang Liaojun Hao Yin Hong Tang | 2010 | China Communications2010，7，1： | 2 |
| 8 | Dynamic Matching-Based Spectrum Detection in Cognitive Radio Networks显示文摘Cognitive Radio Network provides an opportunity to reduce the spectrum resource crisis by allowing secondary users to access the idle spectrum allocated to primary users. The precondition of spectrum sharing is to obtain the Spectrum Availability Information(SAI). Energy detection is a typical technology to get SAI. With the mobility of primary users, the energy received by secondary users varies greatly with the distance from the target primary users. Most of the existing energy detection algorithms that use fixed thresholds are not suitable. We propose a Dynamic Matching-Based Spectrum Detection(DMBSD) scheme which can detect sensing data, reduce the impact of malicious data and make final sensing results more accurate with dynamic threshold setting and data matching. Simulation results show that the proposed scheme can detect tempered data, and increase detection probability by decreasing false alarm probability and missed detection probability. | Yu Gu Qingqi Pei Hongning Li | 2019 | China Communications2019，16，4： | 2 |
| 9 | Brassinosteroid-regulated plant growth and development and gene expression in soybean显示文摘Brassinosteroids(BRs) are endogenous phytohormones that play important roles in regulating plant growth and development.In this study, we evaluated the effects of brassinolide(BL, one of the active BRs) on soybean and identified roles of the hormone in regulating multiple aspects of plant growth and development.BL application promoted hypocotyl and epicotyl elongation in the light but blocked epicotyl elongation in the dark.High levels of castasterone and BL accumulated in light-grown plants.BL disrupted shoot negative gravitropism, whereas gibberellin did not.BL delayed leaf senescence.Transcriptome analysis showed that BL induced cell wall-modifying genes and auxin-associated genes but suppressed a class of WRKY genes involved in senescence and stress responses,showing the complex roles of BRs in multiple biological processes. | Wenchao Yin Nana Dong Mei Niu Xiaoxing Zhang Lulu Li Jun Liu Bin Liu Hongning Tong | 2019 | The Crop Journal2019，7，3： | 2 |
| 10 | Expression of rna-interference/antisense transgenes by the cognate promoters of target genes is a better gene-silencing strategy to study gene functions in rice 显示文摘 | Li J Jiang D Zhou H Li F Yang JW Hongn LF Fu XA Li ZB Liu ZL Li JM Zhuang CX | 2011 | PLoS ONE2011，6，17： | 1 |
| 11 | High‐Strength and High‐Ductility Nanostructured and Amorphous Metallic Materials显示文摘 | Hongning Kou Jian Lu Ying Li | 2014 | Adv. Mater2014，，31： | 1 |
| 12 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 13 | 显示文摘 | Yang Yu Mao Xu Li Hongning | 2000 | Physica E2000，8，： | 1 |
| 14 | Recent developments of the high strength and high ductility nanostructured materials显示文摘This talk will summarize the recent work related to a kind of new nanomaterials produced by the SMAT (surface mechanical attrition treatment).The concept of surface nanocrystallization of materials will be presented.In terms of the grain refinement mechanism induced by plastic deformation,a novel surface mechanical attrition(SMA) technique was developed for synthesizing a nanostructured surface layer on metallic materials in order to upgrade the overall properties and performance.The grain refinement mechanism of the surface layer during the SMA treatment will be analyzed in terms of the nanostructure observations in several typical materials.Very high yield stress(5 times of the base material) on the surface layer of the material obtained by the SMAT has been observed.The effect of surface nanostructures on the mechanical behavior and on the failure mechanism of metallic material shows the possibility to develop a new strength gradient composite using co-rolling and nitriding.The role of residual stress induced during the treatment will be investigated and discussed.The developed materials are also porosity free materials which can be used as reference material for the local mechanical behavior investigation technique such as the nanoindentation.A general concept for obtaining high strength and high ductility nanostructured materials will be presented.The exceptional high strength and high ductility steels have developed.The simulation of the mechanisms for improving ductility of high strength nanostructured materials will be presented.The potential applications for the land transportation vehicles(car,bus,train) and wind energy have been investigated.Some examples of concept design for the integration of the advanced nanostructured steels will be presented. | Jian LU,Aiying CHEN,Hongning KOU,Ying LI,Leyu WANG and Chunsheng WEN Department of Mechanical Engineering,The Hong Kong Polytechnic University,Hung Hom Kowloon,Hong Kong,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 15 | Channel Selection Information Hiding Scheme for Tracking User Attack in Cognitive Radio Networks显示文摘For the discontinuous occupancy of primary users in cognitive radio networks(CRN),the time-varying of spectrum holes becomes more and more highlighted.In the dynamic environment,cognitive users can access channels that are not occupied by primary users,but they have to hand off to other spectrum holes to continue communication when primary users come back,which brings new security problems.Tracking user attack(TUA) is a typical attack during spectrum handoff,which will invalidate handoff by preventing user accessing,and break down the whole network.In this paper,we propose a Channel Selection Information Hiding scheme(CSIH) to defense TUA.With the proposed scheme,we can destroy the routes to the root node of the attack tree by hiding the information of channel selection and enhance the security of cognitive radio networks. | LI Hongning PEI Qingqi MA Lichuan | 2014 | China Communications2014，11，3： | 1 |
| 16 | Triptolide-loaded microemulsion-based hydrogels: physical properties and percutaneous permeability显示文摘Triptolide is a diterpenoid compound that inhibits the inflammation of rheumatoid arthritis(RA).However,the use of triptolide is limited due to its strong gastrointestinal toxicity.The purpose of this work was to develop a transdermal delivery system for triptolide to reduce this toxicity.A microemulsion-based hydrogel(MBH)was prepared from the combination of Gemseal 40-oleic acid as oil phase,Tween 80-labrasol as surfactant,anhydrous ethanol as co-surfactant,water as aqueous phase and Poloxamer 407 as hydrogel matrix.Rheological measurements,environmental scanning electron microscopy(ESEM)and transdermal experiments in vitro were used to characterize triptolide-loaded and blank MBH preparations.The effects of Poloxamer 407 and triptolide on the rheological properties and microstructures of the MBH were determined.Transparent and homogeneous MBH could only be formed when the concentration of Poloxamer 407 in the selected O/W microemulsion was in the range of 14.0–16.0%(w/w).When the concentration of Poloxamer 407 increased,the rheological properties such as the yield stresses(sy),storage and loss moduli(G′,G″)of the formulations increased,and the network structures became more compact.The addition of triptolide did not change the interconnected network structures of the MBH preparations.MBH preparations afford a better sustained release profile when compared to microemulsions,a finding confirmed by an in vitro permeation test in mice.MBH appears to be a promising vehicle for transdermal delivery of triptolide. | Lihua Chen Xiaoting Zhao Jia Cai Yongmei Guan Sen Wang Hongning Liu Weifeng Zhu Junsong Li | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 1 |
| 17 | Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine显示文摘 | Yi Yang Jianlin Chen Hui Li Yingyi Wang Zhao Xie Mei Wu Huan Zhang Zhongzhong Zhao Qian Chen Manliang Fu Kaiyuan Wu Cheng Chi Hongning Wang Rong Gao | 2006 | Comparative Immunology Microbiology and Infectious Diseases2006，，1： | 1 |
| 18 | Histological Assessment and Transcriptome Analysis Provide Insights into the Toxic Effects of Perfluorooctanoic Acid to Juvenile Half Smooth Tongue Sole Cynoglossus semilaevis显示文摘Perfluorooctanoic acid(PFOA)is a widespread synthetic persistent organic pollutant that may enrich along the food chain and affect the growth,development,reproduction,and lipid metabolism of aquatic organisms,particularly the benthic organisms.How-ever,the toxic effects of PFOA on the half-smooth tongue sole Cynoglossus semilaevis,a commercial benthic fish in China,have rarely been reported.Because juvenile fish are sensitive to environmental pollutants,in the present study,histological assessment and tran-scriptome sequencing were performed to determine the short-term impact of PFOA on juvenile half-smooth tongue soles.Histologi-cal analysis showed that PFOA exposure caused hepatocyte rupture,intestinal villi breakage,increased goblet cell count,and brain ab-normal.Transcriptome results showed that some interesting signaling pathways,such as glycolysis/gluconeogenesis,PPAR signaling pathway and GABAergic synapse signaling pathway,were enriched after PFOA exposure.In addition,some metabolic,immune and neural genes were differentially expressed,which including ependymin,hbb1-like and gad 1,and they were up-regulated after 14 days of exposure.Transcriptome results also indicated that half-smooth tongue sole might improve energy metabolism in response to PFOA toxicity after 7 days of exposure.These findings provide a basis for studying the ecological effects of PFOA on marine benthic fishes. | ZHAN Min SHI Kunpeng ZHANG Xue FAN Qingxin XU Qian LIU Xinbao LI Zhujun LIU Hongning XIA Yanting SHA Zhenxia | 2023 | Journal of Ocean University of China2023，22，6： | 0 |
| 19 | Energy Efficiency-Based Decision Making in Cognitive Radio Networks显示文摘As a constraint for smart devices,energy consumption has attract people's attention for a long time period. How to get higher resource utilization with less energy consumption is a challenge for cognitive radio networks. Secondary users have to participate in spectrum sensing at the cost of energy and access idle spectrum without interfering primary users. However,not all participating secondary users can access idle spectrum. How to ensure the participation users access spectrum efficiently with a larger probability is an urgent problem to be solved. We propose an Energy Efficiency-based Decision Making(EEDM) for cognitive radio networks,which fully considers residual energy and probability of obtaining spectrum resources. Simulation and analysis show that the proposed scheme can maximize proportion of allocated users under the premise of ensuring the accuracy of spectrum sensing,then balance users' energy consumption and access efficiency,so as to effectively improve the utilization of spectrum resources. | Hongning Li Qingqi Pei Leilei Xu | 2016 | China Communications2016，13，11： | 0 |
| 20 | The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto-binding of OsBSK2显示文摘Japonica/geng and indica/xian are two major rice(Oryza sativa)subspecies with multiple divergent traits,but how these traits are related and interact within each subspecies remains elusive.Brassinosteroids(BRs)are a class of steroid phytohormones that modulate many important agronomic traits in rice.Here,using different physiological assays,we revealed that japonica rice exhibits an overall lower BR sensitivity than indica.Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms.Among these,we demonstrate that the C38/T variant in BR Signaling Kinase2(OsBSK2),causing the amino acid change P13L,plays a central role in mediating differential BR signaling in japonica and indica rice.OsBSK2in indica plays a greater role in BR signaling than OsB SK2in japonica by affecting the auto-binding and protein accumulation of OsBSK2.Finally,we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice,including grain shape,tiller number,cold adaptation,and nitrogen-use efficiency.Our study suggests that the natural variation in OsB SK2 plays a key role in the divergence of BR signaling,which underlies multiple divergent traits between japonica and indica. | Wenchao Yin Lulu Li Zhikun Yu Fan Zhang Dapu Liu Hongkai Wu Mei Niu Wenjing Meng Xiaoxing Zhang Nana Dong Yanzhao Yang Jihong Liu Yongqiang Liu Guoxia Zhang Jianlong Xu Shimei Wang Chengcai Chu Qian Qian Hongning Tong | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
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