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| 1 | Mass-independent fractionation of even mercury isotopes显示文摘Practically all physical, chemical, and biological processes can induce mass-dependent fractionation of mercury(Hg) isotopes. A few special processes such as photochemical reduction of Hg(II) and photochemical degradation of methylmercury(Me Hg) can produce massindependent fractionation(MIF) of odd Hg isotopes(oddMIF), which had been largely reported in variable natural samples and laboratory experiments, and was thought to be caused by either nuclear volume effect or magnetic isotope effect. Recently, intriguing MIF of even Hg isotopes(evenMIF) had been determined in natural samples mainly related to the atmosphere. Though photo-oxidation in the tropopause(inter-layer between the stratosphere and the troposphere) and neutron capture in space were thought to be the possible processes causing even-MIF, the exact mechanism triggering significant even Hg isotope anomaly is still unclear. Even-MIF could provide useful information about the atmospheric chemistry and related climate changes, and the biogeochemical cycle of Hg. | Hongming Cai Jiubin Chen | 2016 | Science Bulletin2016，61，2： | 7 |
| 2 | Evidential method to identify influential nodes in complex networks显示文摘Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality measure is proposed based on the Dempster-Shafer evidence theory.The existing measures of degree centrality, betweenness centrality and closeness centrality are taken into consideration in the proposed method. Numerical examples are used to illustrate the effectiveness of the proposed method. | Hongming Mo Cai Gao Yong Deng | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 7 |
| 3 | Healthcare data analytics:using a metadata annotation approach for integrating electronic hospital records显示文摘The data in electronic medical records(EMR)are complex in structure.They are independent,yet related to each other.In order to improve information access through the use of EMR,annotating work on these data is necessary.The annotation on metadata,the resource data which contain a meta-model of the database,is the basis of the annotating work if a semi-automated or an automated annotating approach which aims at making the database more accessible is expected.In this study,a method has been proposed to transform the terms which cannot be matched directly by changing them literally but maintaining their semantics,and then annotating them indirectly.After the transforming work,a refinement method which is reducible to phrase sense disambiguation(PSD)is employed to ensure accuracy.A pilot study on a hospital database has been conducted to test the accuracy and effectiveness of the proposed method. | Boyi Xu Ke Xu LiuLiu Fu Ling Li Weiwei Xin Hongming Cai | 2016 | Journal of Management Analytics2016，3，2： | 6 |
| 4 | Geochronology and Petrogenesis of Mafic-Intermediate Intrusions on the Northern Margin of the Central Tianshan(NW China): Implications for Tectonic Evolution显示文摘Late Paleozoic mafic-intermediate intrusions are widespread in the central Tianshan belt, but their tectonic settings remain controversial. Petrogenesis of these intrusions can provide insights into the tectonic evolution of the belt and its adjacent areas. This study presents new whole-rock geochemical and zircon U-Pb geochronology and Hf isotopic data for the Yaxi diorite and Qianzishan gabbro on the northern margin of the central Tianshan(NW China). Zircon U-Pb dating yielded the magma crystallization ages of 313±4 and 295±4 Ma for the Yaxi diorite and Qianzishan gabbro, respectively. They have lower Mg# values, Ni and Cr contents than typical mantle-derived primary melt, with negative correlations between MgO, TFeO and SiO2 contents, indicating clinopyroxene and olivine fractionation during magma evolution. They are characterized by enrichment of large ion lithophile elements(e.g., Rb, Ba and Sr) and depletion of high field strength elements(e.g., Nb, Ta and Ti) with high Ba/Th and Rb/Y, suggesting that their mantle sources had been metasomatized by slab-derived fluids. In addition, the Qianzishan gabbro has high Al2 O3 contents(19.54 wt.%–20.88 wt.%) and positive Eu anomalies(Eu/Eu*=1.09–1.42), which can be attributed to accumulation of plagioclase. Geochemical and zircon Hf isotopic compositions reveal that both the Yaxi diorite and Qianzishan gabbro were derived from depleted lithospheric mantle in the spinel stability field with insignificant crustal contamination. In association with previous investigations, we suggest that the Yaxi and Qianzishan intrusions were emplaced in a subduction-related environment, which means that the subduction of the Junggar Ocean lasted at least to the earliest Permian. | Hongming Cai He Yang Xiangkuan Gong | 2019 | Journal of Earth Science2019，30，2： | 2 |
| 5 | A linked data-based approach for clinical treatment selecting support显示文摘Treatment plan selection is a complex process because it sometimes needs sufficient experience and clinical information.Nowadays it is even harder for doctors to select an appropriate treatment plan for certain patients since doctors might encounter difficulties in obtaining the right information and analyzing the diverse clinical data.In order to improve the effectiveness of clinical decision making in complicated information system environments,we first propose a linked data-based approach for treatment plan selection.The approach integrates the patients’clinical records in hospitals with open linked data sources out of hospitals.Then,based on the linked data net,treatment plan selection is carried on aided by similar historical therapy cases.Finally,we reorganize the electronic medical records of 97 colon cancer patients using the linked data model and count the similarity of these records to help treatment selecting.The experiment shows the usability of our method in supporting clinical decisions. | Lihong Jiang Ling Li Hongming Cai Hua Liu Jingyuan Hu Cheng Xie | 2014 | Journal of Management Analytics2014，1，4： | 1 |
| 6 | Semantic Driven Design Reuse for 3D Scene Modeling 显示文摘 | Cao Xue Cai Hongming Bu Fenglin | 2012 | JournaI of ShanghaiJiaotong University (Science)2012，，2： | 1 |
| 7 | Optimal threshold selection algorithm in edge detection based on wavelet transform 显示文摘 | Wu Yong He Yuanjun Cai Hongming | 2005 | Image Vision Cmputing2005，，23： | 1 |
| 8 | Optimal threshold selection algorithm in edge detection based on wavelet transform显示文摘 | Yong Wu Yuanjun He Hongming Cai | 2005 | Image and Vision Computing2005，23，： | 1 |
| 9 | South-hemispheric marine aerosol Hg and S isotope compositions reveal different oxidation pathways显示文摘Particle-bound mercury(PBM)records the oxidation of elemental mercury,of which the main oxidation pathways(Br∙/Cl∙/OH∙/O3)remain unclear,especially in the Southern Hemisphere.Here,we present latitudinal covariations of Hg and Sisotopic anomalies in cross-hemispheric marine aerosols that evidence an equator-to-poleward transition of Hg oxidants from OH∙/O3 in tropics to Br∙/Cl∙in polar regions highlighting thus the presence of distinct oxidation processes producing PBM.The correlations between Hg,S and O-isotopic compositions measured in PBM,sulfates and nitrates respectively within the aerosols highlight the implication of common oxidants in their formations at different latitudes.Our results open a new window to better quantify the present-day atmospheric Hg,S and N budgets and to evaluate the influences of aerosols on climate and ecosystems once the isotopic fractionations associated with each process have been determined. | David AuYang Jiubin Chen Wang Zheng Yanxu Zhang Guitao Shi Jeroen ESonke Pierre Cartigny Hongming Cai Wei Yuan Liangzhi Liu Pengxue Gai Congqiang Liu | 2022 | National Science Open2022，1，2： | 1 |
| 10 | Terpenesfrom Ligularia intermedia 显示文摘 | Chen Hongming Zhang Keqin Cai Mengshen | 1998 | Indian Journal of Chemistry SectionB Organic Including Medicinal1998，37，7： | 1 |
| 11 | Three Dimensional Metal-Surface Processing Parameter Generation Through Machine Learning-Based Nonlinear Mapping显示文摘The accuracy and efficiency of three-dimensional(3D)surface forming,which directly affects the cycle and quality of production,is important in manufacturing.In practice,given the uncertainty of metal plate springback,an error exists between the actual plate and the target surface,which creates a nonlinear mapping from computer aided design models to bending surfaces.Technicians need to reconfigure parameters and process a surface multiple times to delicately control springback,which greatly wastes human and material resources.This study aims to address the springback control problem to improve the efficiency and accuracy of sheet metal forming.A basic computation approach is proposed based on the DeepFit model to calculate the springback value in 3D surface bending.To address the sample data shortage problem,we put forward an advanced approach by combining a deep learning model with case-based reasoning(CBR).Next,a multi-model fused bending parameter generation framework is devised to implement the advanced springback computation approach through surface data preprocessing,CBR-based model matching,convolution neural network-based machining surface generation,and bending parameter generation with a series of model transformations.Moreover,the proposed approaches and the framework are verified by considering saddle surface processing as an example.Overall,this study provides a new idea to improve the accuracy and efficiency of surface processing. | Min Zhu Yanjun Dong Bingqing Shen Haiyan Yu Lihong Jiang Hongming Cai | 2023 | Tsinghua Science and Technology2023，28，4： | 0 |
| 12 | 评估帕博利珠单抗在中国晚期黑色素瘤患者中的应用:基于KEYNOTE-151研究的3年随访数据显示文摘中国肢端和黏膜黑色素瘤的发病率较高,但治疗选择有限,晚期黑色素瘤患者的生存率普遍较低。对Ib期KEYNOTE-151研究的初步分析显示,帕博利珠单抗在作为二线药物治疗中国晚期黑色素瘤患者中,表现出了良好的耐受性和优异的临床抗肿瘤活性。本研究分析了3年随访的研究数据,纳入一线治疗后进展的不可切除的III/IV期中国黑色素瘤患者,给予帕博利珠单抗2 mg/kg治疗,每3周1次,最长使用35剂。主要终点为安全性和客观缓解率(objective response rate,ORR);次要终点包括疗效维持时间(duration of response,DOR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。根据RECIST v1.1标准,采用独立中心盲法评估患者疗效。此外,根据黑色素瘤亚型,以及BRAF突变状态和PD-L1表达状态(仅肢端黑色素瘤)进行亚组分析。本研究共纳入103例患者,中位随访时间[从首次用药到数据截止时间(2020年7月13日)]为44.6个月[四分位距(interquartile range,IQR):39.1–46.2]。85.4%的患者发生了任一级别的治疗相关不良事件(treatment-related adverse events,TRAEs),12.6%的患者发生了3/4级的TRAEs,无5级TRAE发生。3例患者因TRAEs(免疫相关肝炎、肺炎和关节炎)停药。免疫相关AEs和输液反应发生比例为34.0%(3/4级,2.9%)。ORR为17.6%(95%CI:10.8–26.4;1例完全缓解/17例部分缓解),中位DOR为13.8个月(范围:2.7–37.4+)。中位PFS为2.8个月(95%CI:2.7–3.5),36个月的PFS率为5.0%。中位OS为13.2个月(95%CI:10.4–16.5),36个月的OS率为22.3%。肢端黑色素瘤中位OS为14.8个月,非肢端皮肤黑色素瘤为13.5个月,黏膜黑色素瘤为7.4个月。在肢端黑色素瘤亚组中,程序性死亡配体-1(programmed death ligand-1,PD-L1)阳性的中位OS为22.8个月,PD-L1阴性的中位OS为8.4个月,BRAF野生型的中位OS为18.5个月,BRAF突变型的中位OS为5.8个月。综上,本研究对3年随访数据分析结果表明,帕博利珠单抗作为二线治疗在中国晚期黑色素瘤患者中的安全性可控,且达到了具有临床意义的抗肿瘤活性,使部分患者获得持久缓解。亚组分析表明PD-L1阳性和BRAF野生型的肢端黑色素瘤患者从该治疗中获益较大,但由于亚组样本量较小,该研究结论仍需进一步验证。 | Lu Si Xiaoshi Zhang Yongqian Shu Hongming Pan Di Wu Jiwei Liu Lili Mao Xuan Wang Xizhi Wen Yanhong Gu Lingjun Zhu Shijie Lan Xin Cai Scott J.Diede Haiyan Dai Cuizhen Niu Jianfeng Li Jun Guo 李雯钰(翻译校对) 斯璐(点评) | 2023 | 癌症2023，42，8： | 0 |
| 13 | Healthcare data analysis system for regional medical union in smart city显示文摘Regional medical unions are practical approaches to deal with the cases that patients crowd in Grade 3 Class A general hospitals in metropolitan cities such as Shanghai,in China.However,electronic medical data analysis exists challenges when patients are referred among different hospitals in the regional medical unions during treatment procedures.In smart cities,demands for medical services provided by smart devises,complicate the environment of medical data analysis.In order to tackle the above problems,in this paper,a healthcare data analysis system for regional medical union is designed to support doctors from different hospitals to assess health conditions of patients in an overall data view.Behaviour patterns are mined from physiological index values.Tags are generated from social networks data to find the hot topics concerned by people living in common region.Experiments are given to illustrate the feasibility of the system in supporting healthcare data analysis. | Boyi Xu Ling Li Daiping Hu Bin Wu Congcong Ye Hongming Cai | 2018 | Journal of Management Analytics2018，5，4： | 0 |
| 14 | Coprecipitation of metal ions into calcite: an estimation of partition coefficients based on field investigation显示文摘Trace elements(and their isotopes)in carbonates are commonly used to reconstruct paleoenvironment and paleoclimate.Understanding the processes and mechanisms of element incorporation into carbonates is thus crucial for using such geochemical parameters as paleoclimate proxies.In contrast to laboratory-based experimental results,the partitioning of trace metals between solid and solution phases in natural carbonate precipitation systems has rarely been reported.In this study,we investigated the partition coefficients of metal ions between solid and solution in the channel of the natural Baishuitai travertine system,Yunnan,China.Our results show that the partition coefficients of Li+,Na+,Mg2+,Sr2+and Ba2+are<1,that of Ni2+is approximately 1,and those of Co2+,Mn2+,Zn2+and Cu2+are>1,consistent with the results found in previous experimental studies.Although the substitution for Ca2+is likely the main uptake process of these metals into calcite,depending on their ionic radius and charge,trace elements may also be incorporated by adsorption or physical entrapment.Our study shows that unlike laboratory experiments performed under specific conditions,the partitioning of metals between two phases in the natural travertine system could be controlled by several,even multiple,environmental factors(e.g.,carbonate deposition rate,temperature,and pH),which should be taken into account when using trace metals(and their isotopes)in carbonate archives as a paleoclimate proxy. | Zhongwei Wang Jiubin Chen Hongming Cai Wei Yuan Shengliu Yuan | 2021 | Acta Geochimica2021，40，1： | 0 |
| 15 | Efficacy,safety and pharmacokinetics of Unecritinib(TQ-B3101)for patients with ROS1 positive advanced non-small cell lung cancer:a Phase I/II Trial显示文摘This phase I/II trial characterized the tolerability,safety,and antitumor activities of unecritinib,a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1,ALK,and c-MET,in advanced tumors and ROS1 inhibitor-naive advanced or metastatic non-small cell lung cancer(NSCLC)harboring ROS1 rearrangements.Eligible patients received unecritinib 100,200. | Shun Lu Hongming Pan Lin Wu Yu Yao Jianxing He Yan Wang Xiuwen Wang Yong Fang Zhen Zhou Xicheng Wang Xiuyu Cai Yan Yu Zhiyong Ma Xuhong Min Zhixiong Yang Lejie Cao Huaping Yang Yongqian Shu Wu Zhuang Shundong Cang Jian Fang Kai Li Zhuang Yu Jiuwei Cui Yang Zhang Man Li Xinxuan Wen Jie Zhang Weidong Li Jianhua Shi Xingxiang Xu Diansheng Zhong Tao Wang Jiajia Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
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