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| 1 | 结肠癌完整结肠系膜切除——规范化质量控制手术的趋势显示文摘全直肠系膜切除已成为直肠癌手术中应用最广泛的全球化规范治疗手段,但结肠癌手术目前尚缺乏规范化手术方式。完整结肠系膜切除作为结肠癌规范化手术的新理念由德国Hohenberger首次提出,该术式以胚胎解剖学为基础,更符合肿瘤学特点,后续研究发现该术式可改善预后,降低局部复发率,并不增加术后并发症发生率。完整结肠系膜切除的手术要点主要包括:锐性分离脏层、壁层筋膜;中央血管根部结扎;确保合理淋巴结清扫范围。结肠系膜完整切除术的提出是结肠癌外科治疗观念的更新,在经多中心前瞻性研究证实后,有可能成为大肠癌手术又一新的手术典范。 | 叶颖江 Hohenberger W 王杉 | 2011 | 中国实用外科杂志2011，31，6： | 54 |
| 2 | Recent results of laparoscopic surgery in inflammatory bowel disease显示文摘Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional approach.Inflammatory alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed laparoscopically.The current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is presented.CD limited to the terminal ileum has become a common indication for laparoscopic surgical therapy.In severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative time.Studies comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic approach.Even complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low morbidity.In UC, restorative proctocolectomy is the standard procedure in elective surgery.The demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various studies.An increased body mass index and acute inflammation of the bowel may be relative contraindications.Short and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic surgery.Multiple studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under investigation.Technical considerations are playing an important role for the complexity of both diseases. | Hermann Kessler Jonas Mudter Werner Hohenberger | 2011 | World Journal of Gastroenterology2011，17，9： | 7 |
| 3 | 直肠癌切除术后吻合口漏与患者长期预后的关系显示文摘目的 :探讨吻合口漏与直肠癌术后局部复发和生存率的关系。方法 :对 1978年~ 1996年行直肠癌前切除术的 814例患者进行随访 ,并对发生与未发生吻合口漏患者的预后进行了单因素和多因素分析。结果 :814例中 89例 (10 .9% )发生了吻合口漏。经过Kaplan Meier生存曲线分析 ,患者总体 5a局部复发率是 13.6 %。多因素分析显示吻合口漏是影响肿瘤局部复发的独立危险因素 (相对危险度为 1.7,P =0 .0 4 18) ,也是影响肿瘤相关生存率的独立危险因素 (相对危险度为 1.6 ,P =0 .0 172 )。结论 :吻合口漏是影响直肠癌患者术后局部复发率和肿瘤相关生存率的危险因素。 | 王文跃 Susanne Merkel Paul Hermanek Werner Hohenberger | 2001 | 中日友好医院学报2001，15，6： | 6 |
| 4 | The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery显示文摘 | K. S?ndenaa P. Quirke W. Hohenberger K. Sugihara H. Kobayashi H. Kessler G. Brown V. Tudyka A. D’Hoore R. H. Kennedy N. P. West S. H. Kim R. Heald K. E. Storli A. Nesbakken B. Moran | 2014 | International Journal of Colorectal Disease2014，，4： | 3 |
| 5 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 6 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 7 | Role of Surgery Combined with Kinase Inhibition in the Management of Gastrointestinal Stromal Tumor (GIST)显示文摘 | Peter Hohenberger MD PhD Burton Eisenberg MD | 2010 | Annals of Surgical Oncology2010，，10： | 2 |
| 8 | Standardized surgery for colonic cancer:complete mesocolic excision and central ligation-technical notes and outcome显示文摘 | Hohenberger W Weber K Matzel K | | 0，，04： | 2 |
| 9 | Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis显示文摘 | Claus Schildberg R. Croner S. Merkel V. Schellerer V. Müller S. Yedibela W. Hohenberger G. Peros A. Perrakis | 2012 | World Journal of Surgery2012，，4： | 2 |
| 10 | S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL显示文摘 | C. Pox S. Aretz S. Bischoff U. Graeven M. Hass P. Heu?ner W. Hohenberger A. Holstege J. Hübner F. Kolligs M. Kreis P. Lux J. Ockenga R. Porschen S. Post N. Rahner A. Reinacher-Schick J. Riemann R. Sauer A. Sieg W. Scheppach W. Schmitt H. Schmoll K. Schulm | 2013 | Z Gastroenterol2013，，08： | 2 |
| 11 | Preoperative versus postoperative chemoradiotherapy for rectal Cancer显示文摘 | Sauer R Becker H Hohenberger W | | New England Journal of Medicine0，，： | 2 |
| 12 | 腹腔镜下乙状结肠切除、直肠固定术治疗直肠脱垂 | Kessler H. Hohenberger W. 尹勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，1： | 2 |
| 13 | Preoperative versus postoperative chemoradiotherapy for rectal cancer显示文摘 | Sauer R Becker H Hohenberger W | 2004 | N Engl J Med2004，351，17： | 1 |
| 14 | Preoperative versus postoperative chemoradiotherapy for rectal cancer 显示文摘 | Sauer R Becker H Hohenberger W | 2004 | N Engl JMed2004，351，17： | 1 |
| 15 | Standardized surgeryfor colonic cancer: complete mesocolic excision and central liga- tion-technical notes and outcome 显示文摘 | Hohenberger W Weber K Matzel K | 2009 | Colorectal Dis2009，11，4： | 1 |
| 16 | Standardized surgery for colonic cancer: complete mesocolic excision and central liga- tion technical notes and outcome 显示文摘 | Hohenberger W Weber K Matzel K | 2009 | Colorectal Dis2009，11，4： | 1 |
| 17 | Functional outcome after preoperative isolated limb perfusion with rhtnfalpha/mel-phalan for high-grade extremity sarcoma显示文摘 | Hohenberger P Kettelhack C Hermann A | 2001 | Eur J Cancer2001，37，： | 1 |
| 18 | Inhomogeneous electron gas显示文摘 | HOHENBERG P KOHN W | 1964 | Phys Rev B1964，136，： | 1 |
| 19 | Liver transplantation for hepatocellular carcinoma: a single European centre experience显示文摘 | Yedibela S Fortsch T Hohenberger W | 2004 | Langenbecks Arch Surg2004，389，： | 1 |
| 20 | Preoperative versus postoperative chemoradiotherapy for rectal cancer 显示文摘 | Sauer R Becker H Hohenberger W | 2004 | N Engl J Med2004，351，17： | 1 |
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