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| 1 | Diagnostic value of PIVKA-Ⅱ and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma显示文摘AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein(AFP) and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ) in chronic hepatitis B(CHB).METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma(HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic(AUROC) curves of PIVKA-Ⅱ, AFP and their combination were calculated and compared.RESULTS: The optimal cutoff values for PIVKA-Ⅱ and AFP were 40 m AU/m L and 10 ng/m L, respectively, for the differentiation of HCC from nonmalignant CHB. The sensitivity and specificity were 73.9% and 89.7%, respectively, for PIVKA-Ⅱ and 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA-Ⅱ and AFP were not significantly different(0.854 vs 0.853, P = 0.965) for the differentiation of HCC from nonmalignant CHB, whereas the AUROC of PIVKA-Ⅱ was significantly better than that of AFP in patients with cirrhosis(0.870 vs 0.812, P = 0.042). When PIVKA-Ⅱ and AFP were combined, the diagnostic power improved significantly compared to either AFP or PIVKA-Ⅱ alone for the differentiation of HCC from nonmalignant CHB(P < 0.05), especially when cirrhosis was present(P < 0.05).CONCLUSION: Serum PIVKA-Ⅱ might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. | Seung In Seo Hyoung Su Kim Won Jin Kim Woon Geon Shin Doo Jin Kim Kyung Ho Kim Myoung Kuk Jang Jin Heon Lee Joo Seop Kim Hak Yang Kim Dong Joon Kim Myung Seok Lee Choong Kee Park | 2015 | World Journal of Gastroenterology2015，21，13： | 60 |
| 2 | Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging显示文摘Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients. | Nam Kyung Lee Suk Kim Gwang Ha Kim Dong Uk Kim Hyung Il Seo Tae Un Kim Dae Hwan Kang Ho Jin Jang | 2012 | World Journal of Gastroenterology2012，18，31： | 8 |
| 3 | Clear cell papillary renal cell carcinoma: A case report and review of the literature显示文摘Clear cell papillary renal cell carcinoma(ccpRCC) was recently established as a distinct type of epithelial neoplasm by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Here,we report a case of partial nephrectomy for a ccpRCC detected during the routine follow-up of a previously treated liposarcoma in a 70-year-old male patient. The patient was referred to the urology department for a right-sided renal mass(size: 2 cm)detected during routine annual imaging follow-up for a malignant right inguinal fibrous histocytoma and liposarcoma that had been diagnosed 6 and 4 years earlier,respectively,and treated with surgery and adjuvant radiation therapy.Following partial nephrectomy,the renal mass was pathologically diagnosed as ccpRCC,and immunohistochemistry revealed carbonic anhydrase 9(CA9)expression. No recurrences or metastases were detected on follow-up imaging for6 months. This is the first report of partial nephrectomy for incidentally discovered CA9-positive ccpRCC. | Sung Han Kim Whi-An Kwon Jae Young Joung Ho Kyung Seo Kang Hyun Lee Jinsoo Chung | 2018 | World Journal of Nephrology2018，7，8： | 3 |
| 4 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松弛血管平滑肌以减少微冠状动脉血流阻力。研究尼可地尔的心肌保护作用,IONA研究(尼可地尔对心绞痛的作用)即大规模对稳定型心绞痛进行的研究表明,尼可地尔口服给药能够减少冠心病致死率和非致命型心肌梗塞或胸痛意外住院治疗。目前已经对数个不稳定心绞痛(UAP)或急性心肌梗塞病人进行了尼可地尔心脏保护效应的研究评估,但还没有进行大规模研究。此研究的目的在于通过对经尼可地尔注射并PCI治疗12~48h后的不稳定心绞痛患者的心肌酶进行评估来预期考察尼可地尔的心脏保护作用。 | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬 | 2017 | 首都食品与医药2017，24，18： | 3 |
| 5 | Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin显示文摘从 Chlorobium 的 Sepiapterin reductase 微温嗯(cSR ) 催化不同 tetrahydrobiopterin (BH4 ) 的合成, L-threo-BH4,与哺乳动物的酶产品不同。cSR 的 3-D 水晶结构表明了产品配置由在保存得好的催化三个一组以内的底层绑定模式完全是坚定的。在 cSR, sepiapterin 在 Phe-99 和 Trp-196 的二芳香的侧链之间被叠并且旋转在从在老鼠 sepiapterin reductase 的位置的活性部位附近的约 180 度。在底层绑定证实他们的角色,我们变异 Phe-99 或 Trp-196 到丙氨酸(F99A, W196A ) 由指导地点的傻瓜发育不全和由动力学分析和微分扫描热量测定的净化的蛋白质的比较地检验的底层绑定。这些异种比野类型有更高的 K-m 价值。显著地, W196A 变化与 F99A 变化相比导致了更高的 K-m 增加。与结果一致,融化的温度(T-m ) 在变异的蛋白质面对 sepiapterin 是更低的,最糟是 W196A。这些调查结果显示二残余为在 cSR 的底层绑定是不可缺少的,并且 Trp-196 是比为不同立体异构生产的 Phe-99 更重要的。 | Supangat Sun Ok Park Kyung Hye Seo Sang Yeol Lee Young Shik Park Kon Ho Lee | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 1 |
| 6 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘2结果
在200例患者中,36例由于其胸痛不是缺血性心脏病引起的而被排除,9例由于胸痛难以控制在给药12h内需要进行紧急冠状动脉造影术,另外155例在给药12-48h间进行选择性冠状动脉造影术。在155例中,39例没有明显表现出冠状动脉狭窄,13例由于PCI没有表明因此进行了冠状动脉旁路移植术或内科治疗,结果,103例患者接受了PCI,由于没有血液回流或旁支路闭塞,6例按计划或因需要抢救服用IIb/IIIa抑制剂,1例由于完全性心脏传导阻滞需抢救而使用临时起搏器. | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬(译) | 2017 | 首都食品与医药2017，24，24： | 1 |
| 7 | A randomized, prospective trial on efficacy and tolerability of low-volume bowel preparation methods for colonoscopy显示文摘 | In Kyung Yoo Jong Soo Lee Hoon Jai Chun Yoon Tae Jeen Bora Keum Eun Sun Kim Hyuk Soon Choi Jae Min Lee Seung Han Kim Seung Joo Nam Hyo Sung Kang Hong Sik Lee Chang Duck Kim Soon Ho Um Yeon Seok Seo Ho Sang Ryu | 2014 | Digestive and Liver Disease2014，，： | 1 |
| 8 | Pressure and flow distribution in internal gas manifolds of a fuel-cell stack显示文摘 | Joon Ho Koh Hai Kyung Seo Choong G L | 2003 | Journal of Power Sources2003，，115： | 1 |
| 9 | Pressure and flow distribution in internal gas manifolds of a fuel cell stack显示文摘 | John Ho Koh Hai Kyung seo Chong G L | 2003 | Journal of Power Sources2003，，115： | 1 |
| 10 | Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis显示文摘 | Kyung Mo Kim Young Lyun Oh Jae Sung Ko Yon Ho Choe Jeong Kee Seo | 2004 | Journal of Gastroenterology2004，，3： | 1 |
| 11 | 18F-2-Deoxy 2 Fluoro D-glucose positron emission tomography:computed tomography for preoperative staging in gastric cancer patients显示文摘 | Seok Hwa Youn Kyung Won Seo Sang Ho Lee | 2012 | J Gastric Cancer2012，12，3： | 1 |
| 12 | Anthocyanins from black soybean inhibit Helicobacter pylori ‐induced inflammation in human gastric epithelial AGS cells显示文摘 | Jung‐Min Kim Kyung‐Mi Kim En‐Hee Park Ji‐Hyun Seo Jae‐Young Song Sung‐Chul Shin Hyung‐Lyun Kang Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee Hee‐Shang Youn Seung‐Chul Baik | 2013 | Microbiol Immunol2013，，5： | 1 |
| 13 | Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia显示文摘 | Ho Joon Im Kyung Nam Koh Eun Seok Choi Seongsoo Jang Seog Woon Kwon Chan-Jeoung Park Hyun-Sook Chi Jong Jin Seo | 2013 | Biology of Blood and Marrow Transplantation2013，，5： | 1 |
| 14 | Arthroscopic Hybrid Fixation of a Tibial Eminence Fracture in Children显示文摘 | Jong In Kim Jae Ho Kwon Dong Hyun Seo Shaishav M. Soni Michael Mu?oz Kyung Wook Nha | 2013 | Arthroscopy Techniques2013，，： | 1 |
| 15 | Suppression of NF-κB activation and cytokine production by N -acetylcysteine in pancreatic acinar cells显示文摘 | Hyeyoung Kim Jeong Yeon Seo Kwan Ho Roh Joo Weon Lim Kyung Hwan Kim | 2000 | Free Radical Biology and Medicine2000，，7： | 1 |
| 16 | PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer: a retrospective study显示文摘前列腺癌症是第二很普通的男癌症,与继续开发转移的所有病人的一半。更好为前列腺癌症前进和还原剂前列腺在高风险识别病人癌症相关的死亡,改进预示的因素被要求。在这研究,我们使用了 immunohistochemistry (IHC ) 在前列腺癌症的荷尔蒙中间广场前列腺切除术标本决定多重织物 biomarkers 的预示的价值。用在 2002 和 2012 之间收集的 510 个前列腺切除术标本, IHC 分析在修理福尔马林的嵌入石蜡的节上为 Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2,和 Ki-67 被执行。艇长比例的危险模型被用来为前列腺癌症的生物化学的复发(BCR ) 决定预兆的风险因素。在中部的 44 月的后续期间, 128 (25.1%) 病人们开发了 BCR。multivariate 回归分析揭示了那 Ki-67 (危险比率[HR ] :1.60, P = 0.033 ) , PSCA (HR:0.42, P < 0.001 ) ,并且 Cox-2 (HR:2.05, P = 0.003 ) 是 BCR 的唯一的重要预示的织物标记。切除术边缘地位(HR:1.67, P = 0.010 ) ,病理学的 pT0/1/2 舞台(对 pT3/4;HR:0.20, P = 0.002 ) ,外科手术前的 PSA 层次(HR:1.03, P < 0.001 ) , biopsied (HR:1.30, P = 0.022 ) 并且病理学(HR:1.42, P = 0.005 ) 格利森分数,和前列腺尺寸(HR:0.97, P = 0.003 ) 是重要 clinicopathologic 因素。与另外的 clinicopathologic 因素一起的 Ki-67, PSCA,和 Cox-2 biomarkers 的表示是为在有临床上局部性的前列腺癌症追随者激进分子前列腺切除术的病人的 BCR 的预示的因素。 | Sung Han Kim Weon Seo Park Bo Ram Park Jungnam Joo Jae Young Joung Ho Kyung Seo Jinsoo Chung Kang Hyun Lee | 2017 | Asian Journal of Andrology2017，19，4： | 1 |
| 17 | Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction显示文摘AIM:To investigate the predictive factors of selfexpandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS:Self-expandable metallic stent placement was technically successful in all patients(100%),and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model,carcinoembryonic antigen(CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio(a HR)= 2.92,95%CI:1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency(P = 0.009; a HR = 0.27,95%CI:0.10-0.72).CONCLUSION:CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure. | Seung Han Kim Hoon Jai Chun In Kyung Yoo Jae Min Lee Seung Joo Nam Hyuk Soon Choi Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck Kim | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
| 18 | Electroacupuncture for abdominal pain relief in patients with acute pancreatitis:A three-arm randomized controlled trial显示文摘Background: Electroacupuncture(EA) may reduce the severity of acute pancreatitis(AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well documented.Objective: This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with AP.Design, setting, participants and interventions: This study was conducted using a randomized, controlled,three-arm, parallel-group and multi-center design. Patients diagnosed with AP were randomly and equally assigned to EA1, EA2 or control groups. All participants received conventional standard-of-care therapy for AP. Local EA alone was administered in EA1, and local plus distal EA was given in EA2.Local EA included two abdominal acupoints, while distal EA included twelve peripheral acupoints. EA groups underwent one session of EA daily for 4 days(days 1–4), or until pain was resolved or discharged.Main outcome measures: The primary outcome measure was the change in the visual analogue scale(VAS;0–100) pain score between baseline and day 5.Results: Eighty-nine participants were randomized into EA1, EA2 and control groups, and 88(EA1, 30;EA2, 29;control, 29) were included in the full-analysis set. VAS score change(median [interquartile range]) on day 5 was(12.3 ± 22.5) in the EA1 group,(10.3 ± 21.5) in the EA2 group, and(8.9 ± 15.2) in the control group. There were not significant differences in the change in VAS score among treatments(P = 0.983). However, time to food intake was significantly shorter in the EA group(EA1 + EA2) than in the control group(median 2.0 days vs 3.0 days), with a hazard ratio of 0.581(P = 0.022;95% CI,0.366–0.924). No significant adverse events occurred.Conclusion: EA treatment did not significantly reduce pain after 4 days of treatment in patients with AP-associated abdominal pain but significantly reduced time to first food intake. | Dong Kee Jang Jun Kyu Lee Chan Yung Jung Kyung Ho Kim Ha Ra Kang Yeon Sun Lee Jong Hwa Yoon Kwang Ro Joo Min Kyu Chae Yong Hyeon Baek Byung-Kwan Seo Sang Hyub Lee Chiyeon Lim | 2023 | Journal of Integrative Medicine2023，21，6： | 0 |
| 19 | COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm显示文摘Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is unknown.Here,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19.Intriguingly,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining severity.We confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU patients.Using an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary damages.These results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients. | Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong Jong Geol Jang Chun Gwon Park Eun Young Choi Jong-Sup Bae Young-Kyo Seo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 20 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘(接2017年12月下)
3讨论
PCI治疗中的冠状动脉疾病患者均出现了心肌肌钙蛋白浓度升高的现象,这是由于PCI过程中心肌细胞被破坏所致。然而,心肌肌钙蛋白浓度并没有很好地被用于监测成功PCI之后对心肌细胞的破坏作用。心肌肌钙蛋白是控制心肌收缩的一种蛋白,且在正常的血液中不会被检测到,因为它是心脏特性指标, | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬 | 2018 | 首都食品与医药2018，25，1： | 0 |
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