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| 1 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 2 | Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，3： | 2 |
| 3 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 4 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 5 | Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer显示文摘 | Albert C. Koong Erin Christofferson Quynh-Thu Le Karyn A. Goodman Anthony Ho Timothy Kuo James M. Ford George A. Fisher Ralph Greco Jeffrey Norton George P. Yang | 2005 | International Journal of Radiation Oncology, Biology, Physics2005，，： | 1 |
| 6 | Anton, a special-purpose machine for molecular dynamics simulation显示文摘 | David E. Shaw Martin M. Deneroff Ron O. Dror Jeffrey S. Kuskin Richard H. Larson John K. Salmon Cliff Young Brannon Batson Kevin J. Bowers Jack C. Chao Michael P. Eastwood Joseph Gagliardo J. P. Grossman C. Richard Ho Douglas J. Ierardi István Kolossváry | 2007 | ACM SIGARCH Computer Architecture News2007，，2： | 1 |
| 7 | Prognostic Value of Survivin in Locally Advanced Prostate Cancer: Study Based on RTOG 8610显示文摘 | Min Zhang Alex Ho Elizabeth H. Hammond Yoshiyuki Suzuki R. Scott Bermudez R. Jeffrey Lee Michael Pilepich William U. Shipley Howard Sandler Li-Yan Khor Alan Pollack Arnab Chakravarti | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，4： | 1 |
| 8 | Specific pomegranatejuice components as potential inhibitors of prostate cancer metasta-sis显示文摘 | Lei Wang Jeffrey Ho Carlotta Glackin | 2012 | Trans Oncol2012，5，5： | 1 |
| 9 | Anton, a special-purpose machine for molecular dynamics simulation显示文摘 | David E. Shaw Martin M. Deneroff Ron O. Dror Jeffrey S. Kuskin Richard H. Larson John K. Salmon Cliff Young Brannon Batson Kevin J. Bowers Jack C. Chao Michael P. Eastwood Joseph Gagliardo J. P. Grossman C. Richard Ho Douglas J. Ierardi István Kolossváry | 2007 | ACM SIGARCH Computer Architecture News2007，，2： | 1 |
| 10 | Collateral Flow Averts Hemorrhagic Transformation After Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，8： | 1 |
| 11 | On-line visual tracking with histogram and articulatingblocks显示文摘 | Nejhum S M Shaled Ho Jeffrey Yang Ming-Hsuan | 2010 | Computer Vision and Image Understanding2010，114，8： | 1 |
| 12 | Differential mortality risk of postprocedural creatine kinase-MB elevation following successful versus unsuccessful stent procedures显示文摘 | Allen Jeremias Donald S. Baim Kalon K.L. Ho Manish Chauhan Joseph P. Carrozza David J. Cohen Jeffrey J. Popma Richard E. Kuntz Donald E. Cutlip | 2004 | Journal of the American College of Cardiology2004，，6： | 1 |
| 13 | Needle Tract Seeding after Radiofrequency Ablation of Hepatic Tumors显示文摘 | Jeffrey D. Jaskolka Murray R. Asch John R. Kachura Chia S. Ho Marc Ossip Florence Wong Morris Sherman David R. Grant Paul D. Greig Steven Gallinger | 2005 | Journal of Vascular and Interventional Radiology2005，，4： | 1 |
| 14 | Presentation and Management of Candida-Associated Vasculitis With Gastrointestinal Involvement in a Pediatric Patient显示文摘 | Steve Kwon John W. Ho George Drugas Jeffrey R. Avansino | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，6： | 1 |
| 15 | Acquiring linear subspaces for face recognition under variable lighting显示文摘 | Kuang Chi Lee Jeffrey Ho David Kriegman | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，5： | 1 |
| 16 | Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration显示文摘 | Jeffrey S. Heier David M. Brown Victor Chong Jean-Francois Korobelnik Peter K. Kaiser Quan Dong Nguyen Bernd Kirchhof Allen Ho Yuichiro Ogura George D. Yancopoulos Neil Stahl Robert Vitti Alyson J. Berliner Yuhwen Soo Majid Anderesi Georg Groetzbach Bernd | 2012 | Ophthalmology2012，，12： | 1 |
| 17 | Impact of Baseline Tissue Status (Diffusion-Weighted Imaging Lesion) Versus Perfusion Status (Severity of Hypoperfusion) on Hemorrhagic Transformation显示文摘 | Jong Hun Kim Oh Young Bang David S. Liebeskind Bruce Ovbiagele Gyeong-Moon Kim Chin Sang Chung Kwang Ho Lee Jeffrey L. Saver | 2010 | Stroke2010，，3： | 1 |
| 18 | Atrial strain rate echocardiography can predict success or failure of cardioversion for atrial fibrillation: A combined transthoracic tissue Doppler and transoesophageal imaging study显示文摘 | Tian Wang Mei Wang Jeffrey W.H. Fung Gabriel W.K. Yip Yan Zhang Pearl P.Y. Ho Deco M.K. Tse Cheuk Man Yu John E. Sanderson | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 19 | The Effect of Temperature on Capacity and Power in Cycled Lithium-ion Batter- ies显示文摘 | Belt Jeffrey R Ho Chinh D Miller Ted J | 2005 | Journal of Power Sources2005，142，： | 1 |
| 20 | Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration显示文摘 | Jeffrey S. Heier David M. Brown Victor Chong Jean-Francois Korobelnik Peter K. Kaiser Quan Dong Nguyen Bernd Kirchhof Allen Ho Yuichiro Ogura George D. Yancopoulos Neil Stahl Robert Vitti Alyson J. Berliner Yuhwen Soo Majid Anderesi Georg Groetzbach Bernd | 2012 | Ophthalmology2012，，12： | 1 |
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