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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | The effect of heat transfer coefficent on thermal residual stresses in spray deposition materials显示文摘 | Ho S Lavernia E J | 1997 | Scripts Materialis1997，36，3： | 2 |
| 4 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 5 | Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during 2001 winter period 显示文摘 | CAO J J LEE S C HO K F | 2003 | Atmos Environ2003，37，： | 1 |
| 6 | Fatigue Failure of Rollers in Crankshaft Fillet Rolling显示文摘 | Choik S Pan J Ho S | 2004 | SAE transactions2004，113，5： | 1 |
| 7 | Kinetics of pollutant sorption by biosorbents : review 显示文摘 | Ho Y S Ng J C McKay G | 2000 | Sep Purif Methods2000，29，2： | 1 |
| 8 | Designing structure-specified mixed optimal controllers using an intelligent genetic algorithm IGA 显示文摘 | Ho S J Ho S Y Hung M H | 2005 | IEEE Trans on Control Systems Technology2005，13，6： | 1 |
| 9 | Improvement of hybridyield by advanced backcross QTL analysis in elite maize显示文摘 | J C HO S R McCouch M E Smith | 2002 | Theor Appl Genet2002，105，： | 1 |
| 10 | Enterovirus 71 outbreaks, taiwan : occur- rence and recognition显示文摘 | Lin TY Twu S J Ho MS et d | 2003 | Emerg Infect Dis2003，9，3： | 1 |
| 11 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 12 | Podocytespecific loss of functional microRNAs leads to rapid glomerular and tubular injury显示文摘 | Ho J Ng KH Rosen S | | 0，，11： | 1 |
| 13 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 14 | Suppressive oligonucleotides protect against collagen-induced arthritis in mice 显示文摘 | Dong L ho S Ishii K J | 2004 | Arthritis Rheum2004，50，5： | 1 |
| 15 | Theaflavin-3,3'-digallat from black tea blocks the nitric oxide synthase by down-regulating the aetivation of NF- kappaB in macrophages 显示文摘 | Lin Y L Tsai S H Lin-Shiau S Y Ho C T Lin J K | 1999 | Eur J Pharmaeol1999，367，： | 1 |
| 16 | herative learning control with initial rectifying action for nonlinear continuous systems 显示文摘 | Li X D Ho J K L Chow T W S | 2009 | lET Proc Control Theory and Applications2009，3，1： | 1 |
| 17 | Wegener's granulornatosis upper respiralory tract and pulmonary radiographic manifestation in 30 cases with pathogenetic consideration 显示文摘 | Shin M S Young K R Ho K J | 1998 | Clinical Imaging1998，22，2： | 1 |
| 18 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 19 | Ion-beam-induced chemical changes in the oxyanions (Moyn-) and oxides (Mox) where M = chromium, molybdenum, tungsten, vanadium, niobium and tantalum 显示文摘 | Ho S F Contarini S Rabalais J W | 1987 | Journal of Physi- cal Chemistry1987，91，18： | 1 |
| 20 | Volvariella volvacea lectinactivates mouse T lymphocytes l)y a calcium dependent pathway显示文摘 | Sze S C W Ho J C K Liu W K | 2004 | J Cell Biochem2004，92，6： | 1 |
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