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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007,26,4: | 20 |
| 2 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007,26,1: | 5 |
| 3 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011,,2: | 4 |
| 4 | 儿童难治性部分性癫痫耐药性的诊断标准 | De Saint Martin A. Hirsch E. 张玉龙 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005,0,2: | 2 |
| 5 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011,,2: | 1 |
| 6 | Efficacy of Treatment for Patients With Achalasia Depends on the Distensibility of the Esophagogastric Junction显示文摘 | Wout O. Rohof David P. Hirsch Boudewijn F. Kessing Guy E. Boeckxstaens | 2012 | Gastroenterology2012,,2: | 1 |
| 7 | Preparation of barium titanate ultrafine powders from a monomeric metallo-organic precursor by combined solid-state polymerisation and pyrolysis显示文摘 | H.-J. Gl?sel E. Hartmann D. Hirsch R. B?ttcher C. Klimm D. Michel H.-C. Semmelhack J. Hormes H. Rumpf | 1999 | Journal of Materials Science1999,,10: | 1 |
| 8 | A comparison of two colorimetric assays, based upon Lowry and Bradford techniques, to estimate total protein in soil extracts显示文摘 | M.A. Redmile-Gordon E. Armenise R.P. White P.R. Hirsch K.W.T. Goulding | 2013 | Soil Biology and Biochemistry2013,,: | 1 |
| 9 | Risk factors for surgical site infection in pediatric cardiac surgery patients undergoing delayed sternal closure显示文摘 | Erika E. Harder Michael G. Gaies Sunkyung Yu Janet E. Donohue David A. Hanauer Caren S. Goldberg Jennifer C. Hirsch | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013,,2: | 1 |
| 10 | Efficacy of Treatment for Patients With Achalasia Depends on the Distensibility of the Esophagogastric Junction显示文摘 | Wout O. Rohof David P. Hirsch Boudewijn F. Kessing Guy E. Boeckxstaens | 2012 | Gastroenterology2012,,2: | 1 |
| 11 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011,,2: | 1 |
| 12 | Wear reduction in AISI 630 martensitic stainless steel after energetic nitrogen ion implantation显示文摘 | S. M?ndl B. Fritzsche D. Manova D. Hirsch H. Neumann E. Richter B. Rauschenbach | 2004 | Surface & Coatings Technology2004,,2: | 1 |
| 13 | Intervention for Recoarctation in the Single Ventricle Reconstruction Trial: Incidence, Risk, and Outcomes显示文摘 | Kevin D. Hill John F. Rhodes Ranjit Aiyagari G. Hamilton Baker Lisa Bergersen Paul J. Chai Gregory A. Fleming J. Curt Fudge Matthew J. Gillespie Robert G. Gray Russel Hirsch Kyong-Jin Lee Jennifer S. Li Richard G. Ohye Matthew E. Oster Sara K. Pasquali An | 2013 | Circulation2013,,9: | 1 |
| 14 | Effects of altered phosphoenolpyruvate carboxylase activities on transgenic C3 plant Solanum tuberosum显示文摘 | Johanna Gehlen Ralph Panstruga Helga Smets Sabine Merkelbach Michael Kleines Petra Porsch Matthias Fladung Irmgard Becker Thomas Rademacher Rainer E. H?usler Heinz-Josef Hirsch | 1996 | Plant Molecular Biology1996,,5: | 1 |
| 15 | Large-scale production of embryonic red blood cells from human embryonic stem cells显示文摘 | Emmanuel N. Olivier Caihong Qiu Michelle Velho Rhoda Elison Hirsch Eric E. Bouhassira | 2006 | Experimental Hematology2006,,12: | 1 |
| 16 | BRAF Mutations in Metanephric Adenoma of the Kidney显示文摘 | Toni K. Choueiri John Cheville Emanuele Palescandolo André P. Fay Philip W. Kantoff Michael B. Atkins Jesse K. McKenney Victoria Brown Megan E. Lampron Ming Zhou Michelle S. Hirsch Sabina Signoretti | 2012 | European Urology2012,,: | 1 |
| 17 | Non-invasive Breath Analysis of Pulmonary Nodules显示文摘 | Nir Peled Meggie Hakim Paul A. Bunn York E. Miller Timothy C. Kennedy Jane Mattei John D. Mitchell Fred R. Hirsch Hossam Haick | 2012 | Journal of Thoracic Oncology2012,,10: | 1 |
| 18 | Amélioration mnésique postopératoire un an après traitement chirurgical de l’épilepsie du lobe temporal显示文摘 | O. Després V. Voltzenlogel E. Hirsch J.-P. Vignal L. Manning | 2010 | Revue Neurologique2010,,3: | 1 |
| 19 | Methodological Challenges of Multiple-Component Intervention: Lessons Learned from a Randomized Controlled Trial of Functional Recovery After Hip Fracture显示文摘 | John P. Allegrante Margaret G. E. Peterson Charles N. Cornell C. Ronald MacKenzie Laura Robbins Roberta Horton Sandy B. Ganz Hirsch S. Ruchlin Pamela Williams Russo Stephen A. Paget Mary E. Charlson | 2007 | HSS Journal2007,,1: | 1 |
| 20 | Stathmin-1 Expression as a Complement to p16 Helps Identify High-grade Cervical Intraepithelial Neoplasia With Increased Specificity显示文摘 | Brooke E. Howitt Marisa R. Nucci Ronny Drapkin Christopher P. Crum Michelle S. Hirsch | 2013 | The American Journal of Surgical Pathology2013,,1: | 1 |